45, -6.22 and -3.08 kcal/mol, respectively. This trend agrees well with experiments that the binding of Gal-1 with TDG is stronger than LBA. Further analysis revealed that the interactions due to direct and water-mediated hydrogen bonds play a significant role to the structural stability of the complexes. The result obtained from this study is useful to formulate a set of rules and derive pharmacophore-based features for designing inhibitors against galectin-1.Communicated by Ramaswamy H. Sarma.

Since 2014, many companies have followed the lead of Apple and Facebook and now offer financial support to female employees to access egg freezing. Australian companies may soon make similar offers. Employer-sponsored egg freezing (ESEF) has raised concerns and there is academic debate about whether ESEF promotes reproductive autonomy or reinforces the ‘career vs. family’ dichotomy. Despite the growing availability of ESEF and significant academic debate, little is known about how ESEF is perceived by the public. The aim of this study was to explore women’s attitudes toward ESEF.

Women aged 18-60

years who resided in Victoria, Australia were invited to complete an online, cross-sectional survey investigating views toward egg freezing. Associations between participant demographics and their views about ESEF were assessed using multinominal logistic regression, adjusted for age and free text comments were analyzed using thematic analysis.

The survey was completed by 656 women, median age 28

years (rangemen ESEF is not viewed as theoretically wrong, but rather it may be acceptable under certain conditions; such as with protections around reproductive freedoms and assurances that ESEF is offered alongside other benefits that promote career building and family. We suggest that there may be a role for the State in ensuring that these conditions are met.Situation awareness is the main reason behind different patterns of unsafe behavior among workers and can play a mediating role in the relationship between predictive situational variables and human error. Ilginatinib This questionnaire-based study carried out with Iranian workers investigated the direct and indirect effects of work pressure, mental workload, human-systems interaction and environmental distractions on three types of human error (i.e., slips, lapses and mistakes). The results of path analysis showed that, based on model fit indexes, the model is appropriately fit (χ2 / df = 3, comparative fit index = 099, Tucker-Lewis index = 0.99, root mean square error of approximation = 026). It was also observed that the effects of four independent variables on all three types of human error are indirect and mediated by situation awareness. Consequently, it is confirmed that situation awareness plays a key role in the occurrence of human error and is a sharp-end causal factor for human error in industrial workplaces.

Gene drive technologies (GDTs) bias the inheritance of a genetic element within a population of non-human organisms, promoting its progressive spread across this population. If successful, GDTs may be used to counter intractable problems such as vector-borne diseases. A key issue in the debate on GDTs relates to what governance is appropriate for these technologies. While governance mechanisms for GDTs are to a significant extent proposed and shaped by professional experts, the perspectives of these experts have not been explored in depth.

A total of 33 GDT experts from different professional disciplines were interviewed to identify, better understand, and juxtapose their perspectives on GDT governance. The pseudonymized transcripts were analyzed thematically.

Three main themes were identified (1) engagement of communities, stakeholders, and publics; (2) power dynamics, and (3) decision-making. There was broad consensus amongst respondents that it is important to engage communities, stakeholders, and puns.

The insights obtained in this interview study give rise to recommendations for the design and evaluation of GDT governance. Moreover, these insights point to unresolved normative questions that need to be addressed to move from general commitments to concrete obligations.The aims of this study were; 1) to identify different movement profiles in sixth graders, and 2) to investigate if there are differences in their mathematical basic (BasicMath) and problem solving (ProbSol) skills between existing movement profiles. The sample included 461 (223 girls, 238 boys) students with a mean age of 11.27 ± .32 years from southern and middle Finland. A latent profile analysis (LPA) revealed four movement profiles “poor movers”, “average movers”, “skilled movers” and “expert movers”. These profiles differed substantially in their motor competence (MC) and health-related fitness (HRF). A multivariate analysis of variance (MANOVA) also revealed that “poor movers” and “average movers” obtained lower results in BasicMath comparing with “skilled movers”. The results of this study suggest that cardiorespiratory and muscular fitness, MC and BasicMath are interrelated.Coping skills represent cognitive, emotional, and behavioral resources to overcome developmental challenges and tasks. Based on Cloninger’s model of personality, the main aim of this study was to analyze the relation among temperament, character, and coping skills in nonclinical pre- and early adolescents by also considering adolescents’ gender and age. One hundred and thirty-eight Italian pre- and early adolescents (52.2% boys and 47.8% girls), aged between 10-14 years (M = 12.33 ± 0.87 SD), filled out the Junior Temperament and Character Inventory and the Children’s Coping Strategies Checklist Revision 1. Regression and relative weights analyses showed that several of adolescents’ personality dimensions did predict their coping skills. Specifically, Harm Avoidance was negatively related to Positive Reframing and Distraction; this latter (i.e., Distraction) was also negatively associated with Novelty Seeking, Self-Directedness, and Cooperativeness. On the contrary, Cooperativeness was positively related to the use of Problem Focus strategy, and Reward Dependence was positively related to Distraction and Social Support.