Recent research has shown that humans are able to implicitly adapt to time-transition contingencies in a task-switching paradigm, indicated by better performance in trials where the task transition (switch vs. repetition) is validly predicted by the pre-target interval compared to trials with invalidly predicted transitions. As participants switched between only two different tasks, not only the transition, but also the specific task was predictable; at least indirectly when taking into account the temporally predicted transition in the current trial together with the task in the previous trial. In order to investigate if the time-based expectancy effect for transition in previous studies was due to a specific task preparation or due to an unspecific transition preparation, three different tasks were used in the present study. One of two possible pre-target intervals (500 and 1500 ms) predicted a task switch in the upcoming trial with 90 % probability, whereas the other interval predicted a task repetition with 90 % probability. Results revealed that participants were able to prepare both upcoming repetition as well as switch requirements based on predictive pre-target intervals. This means that humans seem to be able to prepare a task switch in a rather unspecific manner, most likely by inhibiting the task just performed in the previous trial. By suggesting a two-stage preparation model in which switches as well as repetitions benefit both from time-based transition expectancy, although apparently with different cognitive processes being involved, the present study provides important impulses for future research on the cognitive processes underlying human task-switching behavior.In interference tasks, the magnitude of the congruency effect is reduced in trials that follow an incongruent trial. This congruence sequence effect (CSE) reflects cognitive control processes, yet accounts disagree when and how control is exerted. Here, we address these questions in the context of the prime-target task. In this task, control can either modulate early prime or late target information. Furthermore, control can utilize information specific to the stimulus (perceptual features) or relational information between stimuli (temporal order). Two experiments (N = 41 | N = 62) were conducted using a prime-target task with arrows (prime) and letters (target). We presented either the prime before the target or the target before the prime. For both trial-type transitions, the CSE was assessed. Regarding the first question, when is control exerted, results showed a larger CSE for prime→target relative to target→prime trials. This suggests that control in the prime-target task modulates prime activity. Regarding the second question, how is control exerted, a combined analysis of both experiments showed a larger CSE for repetition of the same prime and target order across two trials (e.g., previous trial prime→target; current trial prime→target) compared to changes (e.g., previous trial prime→target; current trial target→prime), suggesting that control in the prime-target task can employ temporal selection.

Calciphylaxis is a rare life-threatening condition that is characterized by calcification of small blood vessels and soft tissues. This condition is classically described in uraemic patients with end-stage renal failure who are on dialysis or had previous renal transplant. It has also been reported in non-uraemic patients and those who are on warfarin therapy. It is typically associated with high calcium/phosphorus product. Patients classically present with painful skin lesion that evolve into painful ulcers. There are multiple risk factors that were reported to trigger or worsen calciphylaxis. Treatment is a multidisciplinary approach that involves elimination of risk factors, wound management, pain control, and optimization of calcium/phosphorus metabolism. Reported mortality rates are very high especially in the uraemic group.

Here we present a case of a patient, who is on chronic renal dialysis for stage renal failure, who underwent mechanical mitral valve replacement and tricuspid valve repair. In thntation of this condition with particular emphasis on the multiple perioperative risk factors that can potentially trigger the onset of calciphylaxis in postoperative cardiac patients. We also discuss the epidemiology, pathogenesis, diagnosis, histopathological findings, and different lines of treatment of this serious condition and the potential preventative strategies.

Our aims were to determine if the Psoriasis Area Severity Index (PASI) score and serum urate (SU) levels were associated at baseline and whether the change in PASI score during 12 weeks of treatment resulted in a significant change in SU, adjusted for relevant confounders.

Data from patients with psoriasis/PsA (

 = 1042/204) in three phase 3 randomized control trials treated with secukinumab (dose 300 mg,

 = 628) or placebo (

 = 414) were pooled. At baseline, values for SU, PASI and the following covariates were assessed age, sex, BMI, estimated glomerular filtration rate, and medication with diuretics. To assess the changes in PASI (ΔPASI) and SU (Δurate), the differences (week 12 minus baseline) in patients receiving the active drug were used. Multivariable linear regression, adjusting for covariates, was used to assess the association between PASI and SU at baseline with all patients pooled and to assess the association between Δurate and ΔPASI over 12 weeks of treatment with secukinumab.

The degrials.gov, NCT01358578; SCULPTURE clinicaltrials.gov, https//clinicaltrials.gov, NCT01406938.This study aimed to describe the first case of regenerative surgery in haemophiliac implant. Patients with haemophilia often present dental problems. A multidisciplinary approach is suggested in case of dental surgeries to reduce the high bleeding risk. A 41-year-old male patient with mild haemophilia A (FVIII 8.4%), presenting previous epistaxis, noncomplicated tooth extractions and traumatic haemartroses, all treated with single infusions of coagulation factor concentrates, was referred to the dental clinic of the Padua University Hospital based on the recommendation of his attending dentist. At first dental visit the patient reported intense pain in the right lower second molar, with impaired chewing function. After an endodontic unsuccessful treatment the element was judged as no longer recoverable. Atamparib In agreement with the patient the dental element was then extracted, after a combined administration of recombinant factor VIII 3000 IU (35 IU/kg), and tranexamic acid 1,000 mg. The extraction was performed under local anaesthesia, paraperiosteal and truncular, moderate sedation, elevation of an envelope flap.