No significant association between obesity (as measured via waist circumference) and depression was detected (pooled odds ratio 0.722, 95% CI0.465-1.119,

=

0.145) in this group population. The subgroup analyses demonstrated that both female and male older adults with overweight/obesity were significantly less likely to have depression.

The “jolly fat” hypothesis is deemed to be applicable among community-dwelling older adults. Older adults might, therefore, be encouraged to increase their body weight above the normal level to be mentally healthy. Monitoring intentional weight loss among older adults should be reinforced for public health strategies.

The “jolly fat” hypothesis is deemed to be applicable among community-dwelling older adults. Older adults might, therefore, be encouraged to increase their body weight above the normal level to be mentally healthy. Monitoring intentional weight loss among older adults should be reinforced for public health strategies.The healing of tendon-bone in the rotator cuff is featured by the formation of the scar tissues in the interface after repair. This study aimed to determine if the 3D-printed poly lactic-co-glycolic acid (PLGA) scaffolds loaded with bone marrow-derived mesenchymal stem cells (BMSCs) could augment the rotator cuff repair in the rabbits. PLGA scaffolds were generated by the 3D-printed technology; Cell Counting Kit-8 assay evaluated the proliferation of BMSCs; the mRNA and protein expression levels were assessed by quantitative real-time polymerase chain reaction and western blot, respectively; immunohistology evaluated the rotator cuff repair; biomechanical characteristics of the repaired tissues were also assessed. 3D-printed PLGA scaffolds showed good biocompatibility without affecting the proliferative ability of BMSCs. BMSCs-PLGA scaffolds implantation enhanced the cell infiltration into the tendon-bone injunction at 4 weeks after implantation and improved the histology score in the tendon tissues after implantation. The mRNA expression levels of collagen I, III, tenascin, and biglycan were significantly higher in the scaffolds + BMSCs group at 4 weeks post-implantation than that in the scaffolds group. At 8 and 12 weeks after implantation, the biglycan mRNA expression level in the BMSCs-PLGA scaffolds group was significantly lower than that in the scaffolds group. BMSCs-PLGA scaffolds implantation enhanced collagen formation and increased collagen dimeter in the tendon-bone interface. The biomechanical analysis showed that BMSCs-PLGA scaffolds implantation improved the biomechanical properties of the regenerated tendon. The combination of 3D-printed PLGA scaffolds with BMSCs can augment the tendon-bone healing in the rabbit rotator cuff repair model.Fabry disease is caused by a decrease in or loss of the activity of alpha-galactosidase, which causes its substrates globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) to accumulate in cells throughout the body. This accumulation results in progressive kidney injury due to glomerulosclerosis and in heart failure due to hypertrophy. Enzyme replacement therapy (ERT) has been used as the standard therapy for Fabry disease, but it causes a significant financial burden, and regular administration is inconvenient for patients. Because of the short half-life of alpha-galactosidase in vivo, therapeutic methods that can supplement or replace ERT are expected to involve continuous release of alpha-galactosidase, even at low doses. Cell transplantation therapy is one of these methods; however, its use has been hindered by the short-term survival of transplanted cells. CellSaic technology, which utilizes cell spheroids that form after cells are seeded simultaneously with a recombinant collagen peptide scaffold called a μ-piece, has been used to improve cell survival upon implantation. In this study, syngeneic murine embryonic fibroblasts were used to generate CellSaic that were transplanted into Fabry mice. These spheroids survived for 28 days in the renal subcapsular space with forming blood vessels. These results indicate CellSaic technology could be a platform to promote cellular graft survival and may facilitate the development of cell transplantation methods for lysosomal diseases.Volleyball involves movements with and/or without horizontal approaches (i.e., spike jumps, jump setting, blocking). The 5-jump test (5JT) was suggested to assess lower limb explosive power of athletes competing in some disciplines (e.g., soccer, judo, running). It appears that no previous study has investigated the 5JT performance components in volleyball players. This study aimed to test the relationship between 5JT performance and two specific laboratory tests for explosive power (i.e., countermovement jump [CMJ] and squat jump [SJ]). Forty volleyball players (boys, mean age 12.4 ± 0.8 years) were tested for 5JT, CMJ, and SJ tests. 5JT performance was expressed in absolute terms (m), and relative to leg length (5JTLL) and body mass (5JTBM). The SJ and CMJ tests were evaluated using the optojump photoelectric cells and the following data were collected peak power (Pp) of jump (W, W.kg-0.67), peak jumping force (Fpeak, N), peak jumping velocity (Vpeak, m/s), peak heights of CMJ and SJ (CMJH and SJH, respectively, cm). Only significant (p 0.30 were considered. 5JT performance was significantly correlated with SJ, Vpeak (r = 0.90), SJH (r = 0.88), Pp [W.kg-0.67 (r = 0.86), W (r = 0.72)], Fpeak (r = 0.45); and CMJ, Vpeak (r = 0.82), CMJH (r = 0.80), Pp [W.kg-0.67 (r = 0.89), W (r = 0.85)], Fpeak (r = 0.73). 5JTLL values were significantly related to SJ, Pp [W (r = 0.81), W.kg-0.67 (r = 0.74)], Vpeak (r = 0.82); and CMJ, Pp [W (r = 0.73), W.kg-0.67 (r = 0.84)], Vpeak (r = 0.75), Fpeak (r = 0.67)]. 5JTBM values were significantly related to SJ, Pp (W, r = -0.43). To conclude, in youth volleyball players, the 5JT may be viewed as an explosive strength diagnostic instrument under field circumstances.The purpose of this study was to examine the possible ecological association between aggregate blood lead levels (BLL) and rates of child maltreatment. To this end, we employed an ecologic study design, analyzing results from 59,645 child BLL tests between the years 1996 and 2007, and 6,640 substantiated maltreatment investigations from 2006 to 2016 in a large Midwest city. check details Separate Bayesian spatial Poisson conditional autoregressive (CAR) and Bayesian spatial zero-inflated Poisson CAR models were used to predict the occurrence of maltreatment.Bivariate results showed that aggregate rates of maltreatment increased as aggregate BLL increased. Multivariate results showed that medium-exposure BLL census tracts (OR = 1.38) and high-exposure BLL tracts (OR = 1.38) had increased odds of substantiated investigations for any maltreatment compared to low BLL census tracts even after controlling for crime rates, age of the housing stock, and concentrated disadvantage. Our findings, considered with prior research, continue to reveal a confluence of deleterious outcomes in areas where exposure to lead seems elevated.