bovis- B. bigemina-, and Babesia sp. Mymensingh-positive rates were 5.9-52.0%, 9.1-76.3%, and 0-35.7%, respectively. In conclusion, this is the first report of Babesia sp. Mymensingh in Mongolia. In addition, we found that species of Babesia that are capable of causing bovine clinical babesiosis, including B. bovis, B. bigemina, and Babesia sp. Mymensingh, are widespread throughout the country. Being aware of the remarkable antimicrobial potential of S. officinalis L., we aimed to evaluate the antimicrobial activity of the S. officinalis dichloromethane crude extract (SOD), dichloromethane-soluble fractions (SODH and SODD), SODD subfractions (SODD1 and SODD2), and pure substances (manool, salvigenin, and viridiflorol) against periodontopathogens. This bioassay-guided study comprises five antimicrobial tests-determination of the Minimum Inhibitory Concentration (MIC), determination of the Minimum Bactericidal Concentration (MBC), determination of the antibiofilm activity, construction of the Time-kill curve (determination of Bactericidal Kinetics), and determination of the Fractional Inhibitory Concentration Index-on six clinical bacterial isolates and three standard bacterial strains involved in periodontal disease. SOD has moderate activity against most of the tested bacteria, whereas SODD1, SODH1, SODH3, and manool afford the lowest results. The Porphyromonas gingivalis (ATTC and clinical isolate) biofilm is considerably resistant to all the samples. In association with chlorhexidine gluconate, only SODH1 exerts additive action against P. gingivalis (clinical isolate). Therefore, SODH1 and manool are promising antibacterial agents and may provide therapeutic solutions for periodontal infections. Haemocytes play a dominant role in shellfish immunity, being considered the main defence effector cells in molluscs. These cells are known to be responsible for many functions, including chemotaxis, cellular recognition, attachment, aggregation, shell repair and nutrient transport and digestion. There are two basic cell types of bivalve haemocytes morphologically distinguishable, hyalinocytes and granulocytes; however, functional differences and specific abilities are poorly understood granulocytes are believed to be more efficient in killing microorganisms, while hyalinocytes are thought to be more specialised in clotting and wound healing. A proteomic approach was implemented to find qualitative differences in the protein profile between granulocytes and hyalinocytes of the European flat oyster, Ostrea edulis, as a way to evaluate functional differences. Oyster haemolymph cells were differentially separated by Percoll® density gradient centrifugation. Granulocyte and hyalinocyte proteins were separated by 2D-PAGE and their protein profiles were analysed and compared with PD Quest software; the protein spots exclusive for each haemocyte type were excised from gels and analysed by MALDI-TOF/TOF with a combination of mass spectrometry (MS) and MS/MS for sequencing and protein identification. A total of 34 proteins were identified, 20 unique to granulocytes and 14 to hyalinocytes. The results suggested differences between the haemocyte types in signal transduction, apoptosis, oxidation reduction processes, cytoskeleton, phagocytosis and pathogen recognition. These results contribute to identify differential roles of each haemocyte type and to better understand the oyster immunity mechanisms, which should help to fight oyster diseases. In the present study, we characterized CF-14, a novel antimicrobial peptide derived from the catfish skin mucus. The objective of this study was to explore the antimicrobial mechanism of CF-14 against Escherichia coli. The agar-diffusion assay and the microdilution method were used to evaluate the antimicrobial activity and the minimum inhibitory concentration (MIC) of CF-14 against E. coli, respectively. In addition, the absorbance of the bacterial suspension filtrate at 260 nm was measured to quantify the leakage of bacterial cytoplasmic components. The bacterial morphological changes were observed by scanning electron microscopy, while confocal microscopy was used to investigate the localization site of CF-14 in E.coli. The DNA binding ability of CF-14 was evaluated using gel retardation assay and the binding of CF-14 to DnaK was evaluated using Discovery Studio. The results demonstrated that CF-14 exhibited strong antimicrobial activity against E.coli with an MIC of 31.3 μg/mL. Unlike common cationic anti-microbial peptides (AMPs) that target the cellmembrane, CF-14 penetrated the E.coli cell membrane and induced only minormembrane perturbations. Furthermore, the antimicrobial mechanism of CF-14 against E.coli involved DNA binding and competitive inhibition of bacterial DnaK. Finally, by deleting or replacing the amino acid sequence, the antibacterial activity of CF-14 was affected, which helped the optimization of amino acid sequence. Therefore, CF-14 can be a potential antimicrobial peptide. BACKGROUND Exercise oscillatory ventilation (EOV) is a consequence of ventilatory control system instability frequently observed in advanced heart failure (HF) patients and is associated with adverse prognosis. The goal of this study was to evaluate the effect of cardiac resynchronization therapy (CRT) on oscillatory ventilation as quantified by a proposed EOV score. METHODS AND RESULTS Consecutive HF patients (n=35) who underwent clinically-indicated CRT, cardiopulmonary exercise testing (CPET) and carbon dioxide (CO2) chemosensitivity by re-breathe before and 4-6 months after CRT were included in this post-hoc analysis. Quarfloxin order EOV score improved in 22 patients (63%) with CRT. In these patients, left ventricular ejection fraction (LVEF), left atrial volume, brain natriuretic peptide concentration and CO2 chemosensitivity significantly improved post-CRT (p less then 0.05). Furthermore, VE/VCO2 significantly decreased and end-tidal CO2 increased at rest and peak exercise post-CRT. Multiple regression analysis showed only the change of CO2 chemosensitivity to be significantly associated with the improvement of EOV score (b=0.64; F=11.3; p=0.004). In the EOV score non-improvement group (n=13), though LVEF significantly increased with CRT (p=0.015), no significant changes in ventilation or gas exchange were observed. CONCLUSION EOV score was mitigated by CRT and associated with decreased CO2 chemosensitivity.