This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266 .

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266 .Classic telemonitoring for the detection of arrhythmias is well established. The advent of wearable ECG devices is associated with great potential and significant challenges. New data collection pathways have to be integrated into clinical workflows. Preliminary studies indicate that positive effects are to be expected from this new form of telemonitoring.

To compare perioperative and functional outcomes of two different energy sources, holmium laser and bipolar current for endoscopic enucleation of prostate larger than 60mL.

A prospective, monocentric, comparative, non-randomized study was conducted including all patients treated for prostate larger than 60mL, measured by transrectal ultrasound. Patients were assigned to each group based on the surgeons’ practice. Perioperative data were collected (preoperative characteristics, operating, catheterization and hospitalization times, hemoglobin loss, complications) and functional outcomes (IPSS, IPSS Quality of Life (QoL), PSA) at 3months and 1year.

100 patients were included in each group from October 2015 to March 2018. L-Adrenaline mw No differences between HoLEP and plasma groups were observed at baseline, except for mean IPSS score, IPSS QoL score and preoperative PVR that were significantly higher in the HoLEP group. Operating time (142.1 vs 122.4min; p = 0.01), catheterization time (59.6 vs 44.4h; p = 0.01) and hospitalization time (2.5 vs 1.8days; p = 0.02) were significantly shorter in the plasma group. Complication and transfusion rate were no significantly different between HoLEP and plasma. No significant differences were observed concerning functional outcomes at 3months and 1year. The urinary incontinence rate was higher 21.1% vs 6.4% (p < 0.01) at 3months in HoLEP group, but no difference was observed at 1year.

Holmium and plasma are both safe and effective for endoscopic treatment for prostate larger than 60mL. Operating, catheterization and hospitalization times were significantly shorter in the plasma group. The complication rate and functional outcomes were not significantly different.

Holmium and plasma are both safe and effective for endoscopic treatment for prostate larger than 60 mL. Operating, catheterization and hospitalization times were significantly shorter in the plasma group. The complication rate and functional outcomes were not significantly different.

Questions have been raised about the effectiveness of myringoplasty techniques for the large tympanic membrane perforation. Various surgical approaches have been recommended to achieve a satisfactory graft success rate in large tympanic membrane perforations. Consequently, there is a growing body of literature that recognizes this controversial topic in otology. The aim of the present research was to investigate the graft success rate in the anterior tab flap technique in ears with large tympanic membrane perforations.

In this retrospective study, we analyzed 157 ears (belong to 157 patients) which underwent tympanoplasty, intact canal wall mastoidectomy or canal wall down mastoidectomy with anterior tab flap method. Our primary outcome was graft success rate.

We achieved a graft success rate of 89.8% (141 ears from a total of 157 ears) by the usage of anterior tab flap method.

We suggest anterior tab flap as a safe and effective surgical technique for large tympanic membrane perforations.

We suggest anterior tab flap as a safe and effective surgical technique for large tympanic membrane perforations.

Ghrelin has a key role in modulating energy metabolism and weight gain. The present study aimed at studying the potential role of ghrelin in the development and/or exacerbation of organ damage in a mouse model of diet-induced obesity.

Adult mice were fed one of two diets for 20weeks standard high carbohydrate (HC) or high-fat high-sugar (HFHS). Starting week 17, the animals were given regular intraperitoneal ghrelin (160µg/kg) or saline injections Abdominal fat, serum creatinine, and glucose levels, as well as kidney, liver and heart weight and pathology were assessed.

Ghrelin-injected mice showed significant organ damage, which was more exacerbated in HFHS-fed animals. While the HFHS diet was associated with significant liver damage, ghrelin administration did not reverse it. Interestingly, ghrelin administration induced moderate kidney damage and significantly affected the heart by increasing perivascular and myocardium fibrosis, steatosis as well as inflammation. Moreover, serum creatinine levels were higher in the animal group injected with ghrelin.

Ghrelin administration was associated with increased functional and structural organ damage, regardless of diet. The present study provides novel evidence of multi-organ physiologic alterations secondary to ghrelin administration.

Ghrelin administration was associated with increased functional and structural organ damage, regardless of diet. The present study provides novel evidence of multi-organ physiologic alterations secondary to ghrelin administration.

It has comprehensively beenacknowledged that a genetic contribution, especially in immune inflammatory players, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α, are critically involved in the pathophysiology of coronary artery disease (CAD). This meta-analysis study aimed to reach a conclusive understanding of the role of genetic polymorphisms, including IL6 gene C572G (rs1800796) and G174C (rs1800795) as well as TNFA gene G238A (rs361525) and G308A (rs1800629) in susceptibility to CAD.

Two major databases, namely MEDLINE and Scopus, were searched to find the studies surveying the mentioned polymorphisms and CAD susceptibility up to July 2020. Association comparison between the polymorphisms and CAD susceptibility were assessed using pooled odds ratio (OR) and their corresponding 95% confidence interval (CI).

This meta-analysis study was conducted on 69 papers (73 population studies), comprising 5062 patients and 8446 controls for IL6 gene rs1800796 (17 studies), 13801 patients and 16215 controls for IL6 gene rs1800795 (38 studies), 1439 patients and 2850 controls for TNFA gene rs361525 (5 studies), and 5051 patients and 3958 controls for TNFA gene rs1800629 (13 studies), according to inclusion and exclusion criteria.