Higher anti-tumor efficiency was observed for TAP@AuNPs than TA-peptide compared with phosphate-buffered saline after intratumoral injection in tumor-bearing mice. It can be concluded that the design and development of a receptor-specific peptide-AuNP platform will be valuable for theranostic applications in cancer nanomedicine.Acute hematologic toxicity is a frequent adverse effect of beta-emitter targeted radionuclide therapies (TRTs). RXC004 supplier Alpha emitters have the potential of delivering high linear energy transfer (LET) radiation to the tumor attributed to its shorter range. Antibody-based TRTs have increased blood-pool half-lives, and therefore increased marrow toxicity, which is a particular concern with alpha emitters. Accurate 3D absorbed dose calculations focusing on the interface region of blood vessels and bone can elucidate energy deposition patterns. Firstly, a cylindrical geometry model with a central blood vessel embedded in the trabecular tissue was modeled. Monte Carlo simulations in GATE were performed considering beta (177Lu, 90Y) and alpha emitters (211At, 225Ac) as sources restricted to the blood pool. Subsequently, the radioactive sources were added in the trabecular bone compartment in order to model bone marrow metastases infiltration (BMMI). Radial profiles, dose-volume histograms and voxel relative differences were used to evaluate the absorbed dose results. We demonstrated that alpha emitters have a higher localized energy deposition compared to beta emitters. In the cylindrical geometry model, when the sources are confined to the blood pool, the dose to the trabecular bone is greater for beta emitting radionuclides, as alpha emitters deposit the majority of their energy within 70 μm of the vessel wall. In the BMMI model, alpha emitters have a lower dose to untargeted trabecular bone. Our results suggest that when alpha emitters are restricted to the blood pool, as when labeled to antibodies, hematologic toxicities may be lower than expected due to differences in the microdistribution of delivered absorbed dose.Topography mediated contact guidance affects multiple cell behaviors such as establishment of cellular morphology and migration. The direction of cell migration is associated with the establishment of cell polarity, which also affects the primary cilia in migrating cells. POPX2, a partner of PIX2, is involved in pathways essential to primary cilium formation, while over-expression of POPX2 has been reported to cause a loss of cell polarity during migration. This study aims to examine how topographical cues direct morphological changes, and how topography affects the process of cellular migration and primary cilium architecture, in the context of POPX2 over-expression. Thus, the effect of anisotropic topography, 2 μm grating pattern on tissue-culture polystyrene, was used as a contact guidance cue to investigate the migration and cell polarity of POPX2 overexpressing cells, in comparison to control NIH3T3 fibroblast cells. We report that POPX2 overexpressing NIH3T3 cells were more sensitive to surface topograpcal and mechanical cues for directional cell migration.The composite particles composed of quantum dots coated with silica and grafted with copolymer of polyethylene glycol and low molecular weight polyethylene terephthalate (QDs@SiO2-PEG-LMPET) are synthesized. The internal QDs provide luminescent performance and combine with SiO2 to form QDs@SiO2 with good dispersion to solve the defect that small-sized SiO2 is prone to agglomerate. The block polymer LMPET-PEG grafted on the surface can make the composite particles better compatible with the PET matrix. In summary, QDs@SiO2-PEG-LMPET not only play the same role as SiO2 to enhance the crystallization performance of PET matrix, but also provide stable luminescence performance, which is multifunctional additive with broad application prospects.Hafnium oxides (HfO x ) based flexible memristors were fabricated on polyethylene naphtholate (PEN) substrates to simulate a variety of bio-synapse functions. By optimizing the manufacturing conditions of electrode and active films, it is proved that the TiN/HfO x /W/ITO/PEN bilayer device has robust flexibility and can still be modulated after 2000 times of bending. The memristor device exhibits better symmetrical and linear characteristics with excellent uniformity at lower programming power consumption (∼38 μW). In addition, the essential synaptic behaviors have further been achieved in the devices, including the transition from short-term plasticity to long-term plasticity and spike time-dependent plasticity. Through the analysis of I-V curves and XPS data, a switching mechanism based on HfO x /W interface boundary drift is constructed. It is revealed that the redox reaction caused by W intercalation can effectively regulate the content of oxygen vacancy in HfO x . At the same time, bias-induced interfacial reactions will regulate the movement of oxygen vacancies, which emulates bio-synapse functions and improves the electrical properties of the device.Single and few-layered MoS2 materials have attracted attention due to their outstanding physicochemical properties with potential applications in optoelectronics, catalysis, and energy storage. In the past, these materials have been produced using the chemical vapor deposition (CVD) method using MoO3 films and powders as Mo precursors. In this work, we demonstrate that the size and morphology of few-layered MoS2 nanostructures can be controlled, modifying the Mo precursor mechanically. We synthesized few-layered MoS2 materials using MoO3 powders previously exposed to a high-energy ball milling treatment by the salt-assisted CVD method. The MoO3 powders milled for 30, 120, and 300 min were used to synthesize sample MoS2-30, MoS2-120, and MoS2-300, respectively. We found morphologies mainly of hexagons (MoS2-30), triangles (MoS2-120), and fullerenes (MoS2-300). The MoS2 nanostructures and MoO3 powders were characterized by scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, x-ray diffraction, and thermogravimetric analysis. It was found that MoO3 milled powders exhibit oxygen loss and decrease in crystallite size as milling time increases. Oxygen deficiency in the Mo precursor prevents the growth of large MoS2 crystals and a large number of milled MoO3-x + NaCl promote greater nucleation sites for the formation of MoS2, achieving a high density of nanoflakes in the 2H and 3R phases, with diameter sizes in the range of ∼30-600 nm with 1-12 layers. Photoluminescence characterization at room temperature revealed a direct bandgap and exciting trends for the different MoS2 samples. We envisage that our work provides a route for modifying the structure and optical properties for future device design via precursor engineering.