The mb-DTI showed higher mean FA and lower MD (r>.95, p<.002) in whole brain and tumor regions of interest; slightly higher fiber FA, volume, and length; and slightly lower fiber MD in whole brain, arcuate fasciculus, and CST than in s-DTI. These differences were significant for fiber FA in all tracts; length (mm) in arcuate fasciculus; and fiber MD (mm

s

) and volume (mm

) in all patients with tumor involved in the arcuate fasciculus, CST, and whole brain tracts (p = .001). Visual assessment demonstrated that both techniques produced visually similar tracts.

This study demonstrated the clinical potential and significant advantages of preoperative mb-DTI in brain tumor patients.

This study demonstrated the clinical potential and significant advantages of preoperative mb-DTI in brain tumor patients.Quantifying the links between the marine environment, prey occurrence, and predator distribution is the first step towards identifying areas of biological importance for marine spatial planning. Events such as marine heatwaves result in an anomalous change in the physical environment, which can lead to shifts in the structure, biomass, and distribution of lower trophic levels. As central-place foragers, seabirds are vulnerable to changes in their foraging grounds during the breeding season. We first quantified spatiotemporal variability in the occurrence and biomass of prey in response to an abrupt change in oceanography as a result of a marine heatwave event. Secondly, using multivariate techniques and machine learning, we investigated if differences in the foraging technique and prey of seabirds resulted in varying responses to changes in prey occurrence and the environment over a 2.5-yr period. We found that the main variables correlated with seabird distribution were also important in structuring the occurrence and biomass of prey; sea-surface temperature (SST), current speed, mixed-layer depth, and bathymetry. Both zooplankton biomass and the occurrence of fish schools exhibited negative relationships with temperature, and temperature was subsequently an important variable in determining seabird distribution. We were able to establish correlations between the distribution of prey and the spatiotemporal distribution of albatross, little penguins and common-diving petrels. We were unable to find a correlation between the distribution of prey and that of short-tailed shearwaters and fairy prions. For high-use coastal areas, the delineation of important foraging regions is essential to balance human use of an area with the needs of marine predators, particularly seabirds.

This study aimed to evaluate the efficacy of narrative therapy in relieving stigma in oral cancer patients who underwent major surgical treatment.

Health-related stigma compromises mental health and life quality in people with physical or mental abnormalities. Narrative therapy has been implemented to overcome stigma among populations in a diversity of disease states. However, the effectiveness of narrative therapy in relieving stigma among patients with oral cancer is not known.

This study was a randomized controlled trial, in which 100 oral cancer patients were selected and randomly assigned to the ‘narrative therapy’ group, who received narrative therapy treatment in addition to standard care, and the ‘control’ group, who was provided standard care only.

This research combined measurement of several questionnaires to evaluate stigma. Analysis of variance and paired t tests were employed for data analysis.

Findings in this study demonstrated that narrative therapy treatment effectively relieved orient-customized methods, should be encouraged in conducting narrative therapy.

What is already known about this topic? Stigma is common among oral cancer patients, especially those who undergo major surgical resection. Vismodegib chemical structure Psychological intervention is highly recommended in addition to postsurgical care. Narrative therapy might help relieve stigma among oral cancer patients. What this paper adds? Conventional postsurgical care did not improve oral cancer patients’ psychological situation. A 7-week intervention of narrative therapy treatment significantly reduced stigma and enhanced sense of self-worth and social support among oral cancer patients. The implications of this paper Narrative therapy can be clinically accepted as a therapeutic approach to assist oral cancer patients with stigma after major surgery. Tailored approaches, including patient-customized methods, should be encouraged in conducting narrative therapy.The effect of a human vascular endothelial growth factor antibody on the vasculature of human tumor grown in rat brain was studied. Using dynamic contrast-enhanced magnetic resonance imaging, the effects of intravenous bevacizumab (Avastin; 10 mg/kg) were examined before and at postadministration times of 1, 2, 4, 8, 12 and 24 h (N = 26; 4-5 per time point) in a rat model of orthotopic, U251 glioblastoma (GBM). The commonly estimated vascular parameters for an MR contrast agent were (i) plasma distribution volume (vp ), (ii) forward volumetric transfer constant (Ktrans ) and (iii) reverse transfer constant (kep ). In addition, extracellular distribution volume (VD ) was estimated in the tumor (VD-tumor ), tumor edge (VD-edge ) and the mostly normal tumor periphery (VD-peri ), along with tumor blood flow (TBF), peri-tumoral hydraulic conductivity (K) and interstitial flow (Flux) and tumor interstitial fluid pressure (TIFP). Studied as % changes from baseline, the 2-h post-treatment time point began showing significant decreases in vp , VD-tumor, VD-edge and VD-peri , as well as K, with these changes persisting at 4 and 8 h in vp , K, VD-tumor, -edge and -peri (t-tests; p less then 0.05-0.01). Decreases in Ktrans were observed at the 2- and 4-h time points (p less then 0.05), while interstitial volume fraction (ve ; = Ktrans /kep ) showed a significant decrease only at the 2-h time point (p less then 0.05). Sustained decreases in Flux were observed from 2 to 24 h (p less then 0.01) while TBF and TIFP showed delayed responses, increases in the former at 12 and 24 h and a decrease in the latter only at 12 h. These imaging biomarkers of tumor vascular kinetics describe the short-term temporal changes in physical spaces and fluid flows in a model of GBM after Avastin administration.