Surgical Site Infection (SSI) is the most common clinical form of Healthcare-Associated Infections (HAI) in orthopedic and trauma wards.

A retrospective study was conducted at the Department of Orthopedics and Trauma Surgery in Tarnów in 2012-2018. 3 155 patients treated for bone fractures were analyzed, including 1961 Open Reduction of Fracture (FX) and 1 194 Closed Reduction of Fracture with Internal Fixation (CR) surgeries. The study was conducted in accordance with the methodology recommended by the Surveillance Network (HAI-Net), European Centre for Disease Prevention and Control (ECDC). The aim of the study was to assess the incidence of SSI in patients undergoing the FX and CR procedures.

28 SSIs were identified in the examined ward; 16 SSI cases related to the FX procedure and 12 cases related to CR. The incidence for FX was 0.8% and for CR 1%. In patients with diagnosed SSI, the stay in the ward was longer (p <0.001) than in patients without SSI. In FX operations, the standardized risk index (SIR) did not exceed the value of one. Staphylococcus aureus was the most common organism isolated from materials from patients with SSI.

In the examined period, the median age of women was higher than that of men, which may indicate a higher incidence of fractures in women. Patients with diagnosed SSI had a longer stay in the ward than patients without SSI. The incidence of SSI in FX and CR has been reduced compared to previous studies in the same ward.

In the examined period, the median age of women was higher than that of men, which may indicate a higher incidence of fractures in women. Patients with diagnosed SSI had a longer stay in the ward than patients without SSI. The incidence of SSI in FX and CR has been reduced compared to previous studies in the same ward.

Tuberculous meningitis (TbM) and meningitis caused by Listeria monocytogenes (LM) require different treatment regimens and have grave prognosis if therapy is delayed.

Comparison of clinical manifestations, laboratory features and outcome of TbM and LM.

We retrospectively analyzed records of 402 patients with community acquired bacterial meningitis (BM) who were hospitalized between January 2010 and September 2019.

LM and TbM were diagnosed in 28 (7.0%) and 23 (5.7%) patients, respectively. Patients with TbM were more likely to present with hydrocephalus (p<0.001), scored lower on the Thwaites Index (TI) (p<0.001) and had longer duration of symptoms prior to hospitalization (p=0.001). Furthermore, TbM patients had lower concentration of c-reactive protein (CRP) (p<0.001) and lower white blood cells count (WBC) (p=0.035). When compared to BM patients with etiology other than LM and TbM (nLnTbM), TbM patients presented with lower concentration of CRP (p<0.001), and procalcitonin (PCT) (p<0.001), lower WBC (p<0.001), and lower granulocyte percentage of CSF cytosis (p<0.001), but were more likely to present with hydrocephalus (p<0.001), aphasia (p=0.003) and hemiparesis (p=0.008). In comparison with the nLnTbM group, LM patients had lower concentration of CRP (p=0.01), lower WBC (p<0.001), and lower granulocyte percentage of CSF cytosis (p<0.016). LM patients were also more likely to have concomitant cancer (p=0.008), receive immunosuppressive treatment (p<0.001) or be immunocompromised (p=0.015).

TbM patients had less pronounced inflammation but more severe central nervous system complications compared to patients with LM and other etiologies. Furthermore, LM patients, but not TbM patients, were often immunocompromised.

TbM patients had less pronounced inflammation but more severe central nervous system complications compared to patients with LM and other etiologies. Furthermore, LM patients, but not TbM patients, were often immunocompromised.Tick-borne encephalitis virus (TBEV), which causes central nervous system infections, is a major health problem in Europe and Asia. This virus is transmitted mainly via the bite of a tick. However, an infection may also occur as a result of consuming raw milk. In 2018, a total of 3 092 cases of tick-borne encephalitis (TBE) were reported in EU countries. API-2 inhibitor In recent years, TBE has emerged in previously unaffected regions; thus, new endemic areas have been identified. Most cases of TBE occur in spring and autumn, which correlates with increased tick activity. TBE is found in all age groups, including infants. The clinical presentation of TBE varies, but the severity of the infection and risk of complications increase with age. Post-encephalitic syndrome, which affects up to 50% of infected individuals, significantly reduces quality of life. Currently, there is no effective treatment for TBE, and supportive management is used in the acute phase of the disease. Therefore, anti-TBE immunization and the avoidance of tick bites are of key importance in preventing this infection.

At the Auschwitz-Birkenau State Museum (A-BSM) actions have been undertaken to effectively protect employees and minimise risk of SARS-CoV-2 coronavirus spreading from the beginning of the COVID-19 epidemic.

The aim was to present the actions, instructions and procedures introduced at the A-BSM to provide information how to deal with pandemic caused by the SARS-CoV-2 coronavirus in institutions taking care of cultural heritage before and after closure of the Museum for visitors and after reopening.

The described activities were developed at the Museum by a specially established Expert Team.

Groups of employees and places in which they were most exposed to contact with visitors and, as a consequence, at the highest risk of getting infected, were characterised. The employees were provided with personal protective equipment, and at the Museum site, devices essential for maintaining the microbiological cleanliness of the rooms, were placed. In the next stage, instructions and procedures for particular groups of employees were prepared. Visitors were educated about the need of taking precautions and were allowed to disinfect in several places at the Memorial Site. Steps to reduce attendance at this time has also been taken. Procedures for employees of the A-BSM were developed in such way that they can also be used after reopening of the Museum for visitors.

The actions which ensured the microbiological safety of the A-BSM employees, brought satisfying results. In more than 21 days after closing of the Museum for visitors, no cases of SARS-CoV-2 infection or COVID-19 were found among employees, despite a very high threat.

The actions which ensured the microbiological safety of the A-BSM employees, brought satisfying results. In more than 21 days after closing of the Museum for visitors, no cases of SARS-CoV-2 infection or COVID-19 were found among employees, despite a very high threat.