The aim To determine informative value of pre-thrombosis, post-thrombosis and anticoagulation factors as well as their correlations for assessment of hemostasis status in patients with stage VD CKD.

Materials and methods Potential predictors of thrombophilia development as well as their relationships depending on the level of molecular markers of hemostasis were studied in 88 patients with stage VD CKD undergoing long-term hemodialysis with the view to determine their informative value.

Results Accumulation of soluble fibrin (sF) was demonstrated to cause moderate reaction of D-dimer (D-d) being insufficient in the absence of reaction of anticoagulant component of hemostasis. Soluble fibrin levels were found to be associated with D-d concentration (r = 0.39) and functionally inactive prothrombin forms (FIPF) to some extent (r = -0.24). Accumulation of FIPF in individuals with high level of sF implies significant activation of blood coagulation system at the stage prior to thrombin formation. Absence of arranging prophylactic measures to prevent thrombophilia.

The aim To evaluate the structural and functional parameters of the cardiovascular system during atrial fibrillation (AF) in patients after a stroke.

Materials and methods In the main group, we selected 28 patients with non-valvular AF who had previously suffered an ischemic stroke (IS). The comparison group (30 people) included patients with AF without a stroke, comparable in age and gender.

Results As a result of the study, we discovered an increase in the risk of stroke with an increase in the thickness of the intima-media complex>0.9mm. The thickness of the interventricular septum was 1.19 (1.1; 1.25) in the group of patients with IS, and in the group of patients without IS – 1.09 (1.0; 1.19) cm (p = 0.019), the thickness of the LV posterior wall is greater in the main group 1.14 (1.05; 1.24) and 1.09 (1.01; 1.18) cm in the comparison group (p = 0.038). The myocardial mass index is 123.3 in the main group and 107.4 g/m2 in the comparison group (p = 0.41), which indicates left ventricle (LV) hypertrophy in the main group.

Conclusions thus, during AF in stroke patients, changes in the following structural and functional parameters of the cardiovascular system were discovered an increase in the thickness of the interventricular septum, thickness of the posterior wall of the LV, and in the thickness of the intima-media complex.

Conclusions thus, during AF in stroke patients, changes in the following structural and functional parameters of the cardiovascular system were discovered an increase in the thickness of the interventricular septum, thickness of the posterior wall of the LV, and in the thickness of the intima-media complex.

The aim To assess the condition of the vaginal ecosystem in pregnant women with BV.

Materials and methods The main group consisted of 60 pregnant women with BV in the II trimester. The bacterioscopic examination, of vaginal smears was carried out. DNA diagnostics of the microbial spectrum of vaginal contents was performed. Bacteria with biofilm were visualized by fluorescence hybridization in situ.

Results Biofilms were found in 25 women (41.65%) of the main group, the main component of which was bacteria belonging to the Gardnerella cluster at a concentration of 7.9 ± 0.13 log CFU/ g. Atopobium vagine cluster bacteria gave positive hybridization signals in more than half of the patients and amounted to 6.8 ± 0.15 lg CFU / g. In addition, Snethia spp. was determined as a part of the biofilm at a concentration of 5.8 ± 0.3 lg CFU / g.

Conclusions Thus, the use of the proposed treatment regimen for women with vaginal dysbiosis led to the elimination of pathogenic and conditionally pathogenic microflora. However, the effectiveness of treatment in 5 cases was lower than expected, which indicates the emergence of bacterial resistance.

Conclusions Thus, the use of the proposed treatment regimen for women with vaginal dysbiosis led to the elimination of pathogenic and conditionally pathogenic microflora. However, the effectiveness of treatment in 5 cases was lower than expected, which indicates the emergence of bacterial resistance.

The aim To study the influence of anxiety and depressive disorders on life quality of patients with arterial hypertension.

Materials and methods 55 patients with arterial hypertension (AH) of 2nd stage were examined to reach the goal. Age diapason was 25-73 years, the middle age was 53.56+10.28. There were 58.2% (32) of women and 41.8% (23) of men among the patients.

Results Results analysis of the investigation of patients with arterial hypertension and anxiety and depressive disorders using the Spielberger-Khanin anxiety inventory showed moderate (30.9%) and high (69.1%) level of trait anxiety. As for the state anxiety the high level of it was confirmed in 74.6% of studied patients and moderate level of state anxiety in 25.5% of patients. During the analysis of gender-based distribution the trait anxiety level was significantly higher in women (p<0.05). Results of PHQ-9 showed subclinical depression level (12.7%), mild (49.1%) and moderate (16.4%). Moderate manifestations of depression were found iing to HADS and PHQ-9 questionnaires. The level of anxiety and depressive episode severity were found to be reliably higher in women in gender-based distribution, that/which was accompanied by decrease in most of the life quality indicators.

The aim To compare the effectiveness and sensitivity of prenatal and postnatal diagnostics in the diagnosis of congenital malformations of the urinary system in the Slovak Republic.

Materials and methods Data of postnatal sonographic screening of congenital developmental malformations of the urinary system in Slovak Republic including 2017 were identified and updated using a questionnaire survey, 38,496 newborns were involved. AT7519 mouse Statistical data on the proportion of prenatal diagnosis for the years 1995, 2000, 2005, 2008 and 2013-2016 were provided from the National Register of Congenital Defects. The chi2-test and t-test were applied to assess the sensitivity differences.

Results The study showed a low sensitivity of prenatal diagnosis with its maximum in 2016, reaching 32.3% and a minimum in 2005-2008 (8.0 – 8.4%). The sensitivity of postnatal diagnostics for selected years has always been a stable indicator and reaches 99.6%.

Conclusions Available statistical data confirm that prenatal diagnostics of congenital developmental malformations of the urinary system in the Slovak Republic is not perfect.