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    Published by Oxford University Press on behalf of the Association of Military Surgeons of the United States 2020. This work is written by (a) US Government employee(s) and is in the public domain in the US.A self-care movement for social workers is beginning to embrace mindfulness and other forms of wellness. However, self-care is often framed as merely an individualistic pursuit and may be a tool of managerialism, reinforcing the social and economic structures and culture that are causing burnout and moral injury in the first place. Particularly for people who are marginalized, the self-care movement may ignore historical trauma and the ways that interlocking oppressions contribute to stress, trauma, moral injury, and burnout. Drawing from the evidence base on East-West mind-body practices and informed by a transformative practice lens, healing justice is presented as a framework and set of practices of the whole self. The whole self includes the physical, emotional, mental, spiritual, social, and ecological selves. A transformative approach to healing can be supported by enhancing the capabilities of mindfulness, compassion, curiosity, critical inquiry, effort, and equanimity. The concept of the healing justice organization is introduced as an opportunity for organizational change beginning with a set of inquiries for social work organizations to attend structurally and more purposefully to collective care. © 2020 National Association of Social Workers.Evidence suggests that the practice of sharing clinicians’ notes with patients via online patient portals may increase patient engagement and improve patient-clinician relationships while requiring little change in providers’ workflow. Authors examined clinical social workers’ experiences and attitudes related to open psychotherapy notes using focus groups and telephone interviews. Twenty-four of 29 eligible therapists agreed to open their notes to patients, and nine participated in this study. Participants were generally positive about their experiences and reported few disruptions to their workload or practice. However, they were hesitant to bring up notes to patients during sessions, and they discussed the benefits of open therapy notes mostly hypothetically. The five therapists who did not share notes worried that open notes would be detrimental to therapeutic relationships, patient well-being, and workflow. However, the concern they discussed most often related to the electronic health record rather than to open notes, because therapy notes are visible to all authorized clinicians as part of the general medical record. Future research is needed to deepen our understanding of the risks and benefits of open psychotherapy notes and to inform development of training programs to support therapists in opening notes. © 2020 National Association of Social Workers.BACKGROUND AND OBJECTIVES Aging women are continuously underrepresented in performing arts. An exception to this trend in Québec is Fabien Cloutier’s latest play Bonne retraite, Jocelyne (2018), whose protagonist is a middle-aged woman who has decided to take early retirement. This article aims at examining the interplay between the protagonist’s voluntary early retirement, gender, social class, and family relationships. RESEARCH DESIGN AND METHODS This article mobilizes the theoretical framework of aging studies, which is underdeveloped in the French academic sphere. This qualitative case study connects gender issues and performative strategies in order to study a complex phenomenon within its context. RESULTS We showed that Cloutier provides new representations of middle-aged women in his play, a corrective to the under-representation of such an age group of actors and actresses in Québec. Our results cast a new light on the combination of class privilege, gender, and ageism, as a most fruitful research orientation to be further developed in the future in order to pursue an in-depth analysis of early retirement. DISCUSSION AND IMPLICATIONS The play reveals that belonging to the upper-middle class is essential in order to be able, economically speaking, to retire early. Cloutier empowers Jocelyne both as an aging individual and as a woman by means of granting her the right to make her own decisions in life. © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.BACKGROUND Increased keratinocyte proliferation occurs in the skin of psoriatic patients and is supposed to play a role in the pathogenesis of this disorder. Compounds interfering with keratinocyte proliferation could be useful in the management of psoriatic patients. AIM To investigate whether albendazole, an anti-helmintic drug that regulates epithelial cell function in various systems, inhibits keratinocyte proliferation in models of psoriasis. Linsitinib ic50 METHODS Aldara-treated mice received daily topical application of albendazole. Keratinocyte proliferation and keratin (K) 6 and K16 expression were evaluated by immunohistochemistry and Western blotting and inflammatory cells/mediators were analysed by immunohistochemistry and real-time PCR. In human keratinocytes (HEKa and HaCaT) treated with albendazole, cell cycle and proliferation, keratins and cell cycle-associated factors were evaluated by flow cytometry, colorimetric assay and Western blotting respectively. RESULTS Aldara-treated mice given albendazole exhibited reduced epidermal thickness, decreased number of proliferating keratinocytes and K6/K16 expression. Reduction of CD3- and Ly6G-positive cells in the skin of albendazole-treated mice associated with inhibition of IL-6, TNF-α, IL-1β, IL-17A, IL-36, CCL17, CXCL1, CXCL2 and CXCL5 expression. Treatment of keratinocytes with albendazole reduced K6/K16 expression and reversibly inhibited cell growth by promoting accumulation of cells in S-phase. This phenomenon was accompanied by down-regulation of CDC25A, a phosphatase regulating progression of cell cycle through S-phase, and PKR-dependent hyper-phosphorylation of eIF2α, an inhibitor of CDC25 translation. In Aldara-treated mice, albendazole activated PKR, enhanced eIF2α phosphorylation and reduced CDC25A expression. CONCLUSIONS Data show that albendazole inhibits keratinocyte proliferation and exerts therapeutic effect in a murine model of psoriasis. © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

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