We did not identify any baseline predictors of sensitization that were associated with objective reactivity to the single-dose challenge using 0.5mg cow’s milk protein.

These data support an estimated ED

for cow’s milk of 0.5mg protein. Values for ED

above 0.5mg for cow’s milk protein proposed for allergen risk management need to be reviewed.

These data support an estimated ED05 for cow’s milk of 0.5 mg protein. Values for ED05 above 0.5 mg for cow’s milk protein proposed for allergen risk management need to be reviewed.

Baloxavir marboxil is a novel antiviral agent for influenza, introduced into clinical practice in 2018. A concern remains about the variant virus with reduced susceptibility after baloxavir exposure and its clinical consequences such as healthcare-seeking behavior.

Using a healthcare database in Japan, we compared the medical resource use following baloxavir and neuraminidase inhibitors (NAIs) treatment among children aged 7-15 years. The study period was from December 2018 to March 2019. The primary endpoint was the composite of hospitalization, laboratory and radiological tests, and antibiotic use over 1-9 days of antiviral treatment. As exploratory analyses, secondary outcomes being each single component of the primary composite were assessed and subgroup analyses comparing baloxavir with each NAI were done.

Data from 115 867 prescriptions in 115 238 children were analyzed (median age 10 years; severe influenza risk in 26%; baloxavir accounting for 43%). Overall, baloxavir use did not increase subsequent medical resource utilization in the composite endpoint (adjusted odds ratio [aOR] 1.04; 95% confidence interval [CI] 0.99-1.09; P = 0.14), as were likelihoods of other secondary outcomes. In the subgroup analysis, baloxavir use was associated with higher medical resource use than oseltamivir (aOR 1.21; 95% CI 1.13-1.31; P < 0.001) and lower resource use than zanamivir (aOR 0.93; 95% CI 0.86-1.00; P = 0.040).

Based on a single-year experience in Japan, prescribing baloxavir rather than NAIs did not increase medical resource utilization within 9 days of treatment, except in one exploratory comparison with oseltamivir.

Based on a single-year experience in Japan, prescribing baloxavir rather than NAIs did not increase medical resource utilization within 9 days of treatment, except in one exploratory comparison with oseltamivir.Micro-fibrous materials are one of the highly explored materials and form a major component of composite materials. In resource-limited settings, an affordable and easy to implement method that can characterize such material would be important. In this study, we report on a smartphone microscopic system capable of imaging a sample in transmission mode. As a proof of concept, we implemented the method to image handmade paper samples-cellulosic micro-fibrous material of different thickness. With 1 mm diameter ball lens, individual cellulose fibers, fiber web, and micro-porous regions were resolved in the samples. UNC0379 Imaging performance of the microscopic system was also compared with a commercial bright field microscope. For thin samples, we found the image quality comparable to commercial system. Also, the diameter of cellulose fiber measured from both methods was found to be similar. We also used the system to image surfaces of a three ply surgical facemask. Finally, we explored the application of the system in the study of chemical induced fiber damage. This study suggested that the smartphone microscope system can be an affordable alternative in imaging thin micro-fibrous material in resource limited setting.Kaposiform haemangioendothelioma (KHE) and tufted angioma (TA) are rare vascular tumors that can cause life-threatening Kasabach-Merritt phenomenon. No evidence-based treatment strategies have yet been established, and its management is still a challenge. The purpose of this multicenter prospective randomized controlled study was to evaluate and compare the efficacy of corticosteroid and vincristine (VCR) in the treatment of KHE and TA. All patients with KHE/TA who met the diagnostic criteria were consecutively recruited. The patients were randomized into a methylprednisolone (MP) group and a VCR group. The primary outcome was the single main parameter effective rate and overall effective rate of corticosteroid and VCR over 1 month after treatment. The single main parameters included platelets, fibrinogen, tumor size, texture, and appearance. From May 2016 to April 2018, a total of 59 patients completed the clinical trial, including 29 in the MP group and 30 in the VCR group. The results showed that VCR was superior to corticosteroid in the improvement of platelet (80.0% vs 44.0%, P = 0.019) and tumor texture (68.9% vs 30.8%, P = 0.007). Although the efficacy of VCR on fibrinogen (23.3% vs 20.7%, P = 1.000), tumor size (23.3% vs 13.8%, P = 0.273), and appearance (65.5% vs 46.2%, P = 0.120) was higher than that of corticosteroid, there was no significant difference (P > 0.05). Meanwhile, the overall effective rate of VCR was higher than that of corticosteroid (56.7% vs 31.0%), but the difference was also not statistically significant (P = 0.067). In conclusion, the therapeutic effect of VCR was significantly better than that of corticosteroid with regard to treating thrombocytopenia and tumor texture. We recommend that VCR could be an option for first-line treatment in KHE/TA patients.

Low satisfaction with normative life domains might be an important factor in the persistence of anorexia nervosa (AN). Initial evidence in non-clinical samples showed that lower satisfaction with normative life domains was related to more intense eating disorder symptoms. As a critical next step, the current study examined satisfaction with normative life domains in a clinical sample. Specifically, the present study tested whether adolescents with AN reported lower satisfaction with normative life domains than adolescents without an eating disorder.

Adolescents with AN (n = 69) and adolescents without an eating disorder matched on age, gender and educational level (n = 69) completed the Brief Multidimensional Students’ Life Satisfaction Scale to assess satisfaction with five life domains (family, friendships, school, self and living location) and life in general.

Adolescents with AN reported significantly lower satisfaction with normative life domains than the comparison group. Subsequent analyses showed that this overall group difference was primarily driven by adolescents with AN reporting lower satisfaction with the self, school experience and life in general.