Exercise induced bronchoconstriction (EIB) is common and underdiagnosed phenomenon of yet largely unknown etiology. This study aimed to estimate prevalence of EIB in response to highly demanding skyscraper race and to test its association with race performance and hypothetical predisposing factors. Healthy participants (26 males, 8 females; 31.5 +/- 6.3 years) from mostly running-based amateur sports were measured for forced expiratory volume in first 1 s (FEV1) before and then repeatedly within 10 min after the completion of the 114 m skyscraper upstairs race. Allergy questionnaire (AQUA) data were collected and post-exercise blood lactate was measured. Over 40% of the participants developed >10% decrement in FEV1 shortly after all-out exercise. While EIB response was not associated with questionnaire-based atopic status, training background, gender, age, anthropometrics, pacing and exertion (estimated from the accumulated blood lactate values), participants exhibiting 10%) were slower indicative of poorer fitness due to EIB developing during the exercise already.Excess body fatness is a consequence of a chronic energy surplus (energy intake is greater than energy expenditure). Given the serious health consequences of excess body fatness, factors that influence energy balance and body composition are increasingly important to understand. Methods – A total of 34 adults between the ages of 19-40 years made a laboratory visit in which height, weight, body composition, and cardiometabolic risk factors were quantified. Participants wore accelerometers for 21-28 days, then returned to the laboratory for a second body composition assessment. Changes in weight and body composition were used to quantify energy balance, and data derived from accelerometers provided markers of physical activity and sedentariness. Results – Of the markers of physical activity that we measured, daily step counts expressed relative to fat mass was most strongly and consistently associated with body fatness and cardiometabolic risk status. Conclusions – Step counts expressed relative to fat mass were strongly associated with body composition and cardiometabolic risk in adults eating ad libitum. Longitudinal interventional studies are necessary to determine the efficacy of step count prescriptions expressed relative to existing and target body fatness and cardiometabolic risk levels for improving weight management and metabolic outcomes.

Schools constitute the ideal setting in which children’s physical activity, physical fitness, and health status can improve. However, intervention protocols and their effectiveness vary considerably. The purpose of the study was to investigate the differences in physical fitness and overweight and obesity prevalence between children attending structured physical education classes held by a specialized teacher (EXP) or traditional classes of equal duration held by an ordinary teacher (TRAD).

Anthropometric and fitness parameters were assessed in a convenience sample of 12,519 1st grade schoolchildren over 3 subsequent school years. Six field-based tests were used to assess physical fitness.

Physical fitness improved more in the EXP group than in the TRAD group, except for flexibility (Sit & Reach). At the end of the 3rd year, the EXP children performed better than did the TRAD children (p<0.001) in Léger (girls +34%, boys +30%), agility shuttle (girls -10%, boys -9%), long jump (girls +9%, boys +8%), frontal basketball throw (girls +11%, boys +10%), and standing balance (girls +18%, boys +28%). The prevalence of obesity and overweight was 5% lower in the EXP than in the TRAD group at the 3-year follow-up.

The proposed teacher-driven intervention, which was focused on the quality rather than the duration of time spent in the gym during school hours, was effective in improving children’s physical fitness. Furthermore, the decrease in the prevalence of obesity and overweight suggests the intervention can improve heavier children’s weight status.

The proposed teacher-driven intervention, which was focused on the quality rather than the duration of time spent in the gym during school hours, was effective in improving children’s physical fitness. Furthermore, the decrease in the prevalence of obesity and overweight suggests the intervention can improve heavier children’s weight status.

The aim of this study was to investigate the molecular basis of maturity-onset diabetes of the young by targeted-gene sequencing of 20 genes related to monogenic diabetes and estimate the frequency and describe the clinical characteristics of monogenic diabetes and MODY in Trakya Region of Turkey.

In 61 cases, a panel of 20 monogenic diabetes related genes were screened. Illumina NextSeq550 system was used for sequencing of the genes. Pathogenicity of the variants were assessed by bioinformatics prediction software programs and segregation analyses.

In 29 (47,5%) cases, 31 pathogenic/likely pathogenic variants in the

genes and in 11 (18%) cases, 14 variants of uncertain significance in the

and

genes were identified. 6 different pathogenic/likely pathogenic variants and 6 different variants of uncertain significance were detected as novel.

This is the first study including molecular studies of twenty monogenic diabetes genes in Turkish cases in Trakya Region. 5′-N-Ethylcarboxamidoadenosine datasheet The results of this study showed that pathogenic variants in the GCK gene are the leading cause of MODY in our population. A high frequency of novel variants (32.4%-12/37) in the current study, suggests that multiple gene analysis provides accurate genetic diagnosis in MODY.

This is the first study including molecular studies of twenty monogenic diabetes genes in Turkish cases in Trakya Region. The results of this study showed that pathogenic variants in the GCK gene are the leading cause of MODY in our population. A high frequency of novel variants (32.4%-12/37) in the current study, suggests that multiple gene analysis provides accurate genetic diagnosis in MODY.

This study was aimed to assess the role of serum midkine (MK) as a biomarker for early detection of diabetic nephropathy (DN) in children with type 1 diabetes mellitus (T1DM) before microalbuminuria emerges.

A total of 120 children with T1DM, comprising 60 microalbuminuric patients ( group 1), 60 normoalbuminuric patients ( group 2), and 60 healthy participants as a control group ( group 3) were included in this study. Detailed medical history, clinical examination, and laboratory assessment of high-sensitivity C-reactive protein (hs- CRP) , hemoglobin A1c% (HbA1c%) , lipid profile , urinary albumin creatinine ratio (ACR), serum MK, and estimated glomerular filtration rate based on serum creatinine (eGFR-Cr) were performed in the three studied group.

Our study revealed significantly higher serum MK in both diabetic groups compared to controls (p < 0.001). Additionally, patients with microalbuminuria had higher serum MK concentrations than those with normoalbuminuria (p<0.001). The normoalbuminuric group had highly significantly elevated serum MK compared with the control group (p < 0.