This study highlights the synergy from heterointerfaces in oxygen electrocatalysis, thus providing a promising approach for advanced metal-air cathode materials.In this paper, we present a novel room temperature (RT) operated SnO2-ZnO-Fe2O3 based tri-composite analyte sensor with dual behavior having detection ability of up to ∼1 ppb with a substantial % response (R) to detect ammonia and ethanol vapors. The tri-composite is synthesized via a sol-gel spin coating technique and characterized using X-ray diffraction (XRD) for structural analysis. Fourier transform infrared spectroscopy (FTIR) and Raman results are used to confirm tri-composite formation. Further, field emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM) and atomic force microscopy (AFM) results are used for examining the detailed surface morphology and structural and topographical characteristics of the tri-composite. The sensing characteristics are monitored from 1 ppb to 50 ppm for ammonia detection and 1 ppb to 25 ppm for ethanol detection at RT (∼27 °C) under ∼45% relative humidity (RH) conditions. A2ti1 This dual sensing behavior (based on change in resistance under ammonia and ethanol exposure) of the sensor is used to differentiate and detect the presence of ammonia (resistance decreases) and ethanol (resistance increases) with high %R within a few seconds. In addition, the sensor showed excellent sensing characteristics under moist conditions (up to 85% RH) and outstanding reproducibility, and was found to be highly stable, selective and specific towards the target analytes. This work not only reports a RT operated ppb level ammonia and ethanol sensor, but also explores the novel SnO2-ZnO-Fe2O3 tri-composite along with a scientific approach towards multi-composite nanostructures to develop analyte sensors.Graphene and graphene-like two-dimensional (2D) nanomaterials, such as black phosphorus (BP), transition metal carbides/carbonitrides (MXene) and transition metal dichalcogenides (TMD), have been extensively studied in recent years due to their unique physical and chemical properties. With atomic-scale thickness, these 2D materials and their derivatives can react with ROS and even scavenge ROS in the dark. With excellent biocompatibility and biosafety, they show great application potential in the antioxidant field and ROS detection for diagnosis. They can also generate ROS under light and be applied in antibacterial, photodynamic therapy (PDT), and other biomedical fields. Understanding the degradation mechanism of 2D nanomaterials by ROS generated under ambient conditions is crucial to developing air stable devices and expanding their application ranges. In this review, we summarize recent advances in 2D materials with a focus on the relationship between their intrinsic structure and the ROS scavenging or generating ability. We have also highlighted important guidelines for the design and synthesis of highly efficient ROS scavenging or generating 2D materials along with their biomedical applications.Precise discrimination of breast cancer remains a challenge in clinical medicine, which depends on the development of novel specific molecular probes. However, the current technologies and antibodies cannot achieve precise discrimination of breast cancer subtypes very well. To address this problem, a novel truncated DNA aptamer MF3Ec was developed in this work. Aptamer MF3Ec exhibited high specificity and binding affinity against MCF-7 breast cancer cells with a Kd value of 18.95 ± 2.9 nM which is four times lower than that of the original aptamer, and could work at 4 °C, 25 °C and 37 °C with no obvious differences. Besides, aptamer MF3Ec displayed better stability in serum samples with a long existence time of about 12 h. Moreover, fluorescence imaging experiments indicated that aptamer MF3Ec was able to distinguish MCF-7 breast cancer cells from SK-BR-3, MDA-MB-231 and MCF-10A breast cancer cell subtypes, and differentiate the tumor-bearing mice and xenografted tissue sections of MCF-7 breast cancer cells from those of MDA-MB-231 and SK-BR-3 breast cancer cells in vivo and in vitro, respectively. Finally, clinical experiments indicated that aptamer MF3Ec could distinguish Luminal A breast cancer subtype from Luminal B (HER2+), HER2-enriched, and triple-negative breast cancer subtypes, para-carcinoma tissues and normal breast tissues. Collectively, all these results suggest that aptamer MF3Ec is a promising probe for precise discrimination and targeted therapy of Luminal A breast cancer molecular subtype.In this review, recent progress in the application of CO2 as an electrophilic reagent and nitrogen as a nucleophilic center under different catalytic conditions in organic synthesis is summarized. The used catalytic methods in the reactions of CO2 and nitrogen are classified as metal catalysis, metal-free catalysis, photocatalysis and electrocatalysis. Various catalytic conditions have been used to solve the problems of thermodynamic properties and stability of CO2. The transformation mechanisms of these reactions are discussed.Black phosphorus (BP) has emerged as a promising two-dimensional (2D) semiconductor for applications in electronics, optoelectronics, and energy storage. As is the case for many 2D materials, the fabrication of large-area BP thin films remains a considerable challenge. Here, we report the assembly of BP nanosheets into compact thin films using the Langmuir-Blodgett (LB) technique. The overlapping stacking between BP nanosheets is suppressed when the nanosheets are surrounded by fullerene C60 molecules due to physisorption. This allows for the fabrication of large-area BP films (20 mm × 18 mm) with a homogenous nanosheet distribution and negligible oxidation. The fabricated films show measurable absorption up to 2.3 μm. We use these films as active layers to demonstrate mm-sized BP heterojunction photodetectors with mA W-1 scale responsivities from the visible to the near-infrared. Photodetector internal quantum efficiencies at 660 nm and 808 nm are 5% and 1%, respectively.Human red blood cells (RBCs) aggregate under low shear conditions, which significantly modulates flow resistance and tissue perfusion. A higher aggregation tendency in blood thus serves as an important clinical indicator for the screening of cardiovascular disorders. Conventional ways of measuring RBC aggregation still require large sample volumes, cumbersome manual procedures, and expensive benchtop systems. These inconvenient and high-cost measurement methods hamper their clinical applicability. Here, we propose a low-cost, miniaturized system to overcome the limitations of these methods. Our system utilizes a coin vibration motor (CVM) to generate a localized vortex for disaggregating RBCs in a disposable fluidic chip. The design of the chip was optimized with fluid dynamics simulations to ensure sufficient shear flow in the localized vortex for RBC disaggregation. The time-dependent increase in light transmittance from an LED light source through the plasma gap while the RBCs re-aggregate is captured with a CMOS camera under stasis conditions to quantify the level of RBC aggregation.