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Fowler Frederick posted an update 9 hours, 34 minutes ago
Purpose Across studies there is great variability in reported rates of stuttering recovery. This study examined the impact that different definitions of recovery had on calculation of recovery rates and factors associated with recovery within the same sample of children. Method Speech samples and parents and child reports of their experiences of stuttering were collected from 38 children who stuttered aged 2-5 years of age (Occassion-1) and again at 9-13 years of age (Occassion-2). Four different criteria for recovery that were developed representing variations in criteria reported in previous research were applied to data from these children. Results . The majority of the participants (82%) showed very little disfluent speech ( less then 1% syllables stuttered) at Occasion 2. Recovery rate varied greatly depending on the criteria used, ranging from 13.2%-94.7%. Definitions ordered from least to greatest recovery that were (a) parent and clinician report no stuttering and no stuttering observed (13.2 %); (b) ≤1% syllables stuttered; severity rated at ≤1; parent, clinician, and child report recovery (55.3 %); (c) ≤1% syllables stuttered; severity rated at ≤1; parent and clinician report recovery (71.1 %); (d) less then 3.0 % syllables stuttered (94.7 %). Five participants were considered recovered and two were considered persistent stutters across all criteria. T-DM1 in vivo Different factors were associated with recovery from stuttering depending on the criterion used. Conclusion The concept of recovery from stuttering is complex and estimations of recovery rate are likely to be greatly affected by differences in definitions and measurement across studies. This has a flow-on effect in determining the factors associated with recovery from stuttering.Purpose The purpose of the study was to determine whether differences exist between young English- and Korean-speaking children who stutter (CWS) in the loci of stuttering. Method Participants were 10 Korean-speaking and 11 English-speaking CWS between the ages of 3 and 7 years. Participants produced narratives while viewing various picture scenes and a wordless picture book. Results Findings indicated that Korean-speaking CWS stuttered more on content than function words whereas English-speaking CWS stuttered more on function than content words. Furthermore, both Korean- and English-speaking CWS tended to stutter more on utterance-initial words. These findings appear to be related to the differences in linguistic/syntactic structures between Korean and English. Specifically, in the Korean-speaking CWS’s narratives, most utterance-initial words (73.60 %) were content words whereas in the English-speaking CWS’s narratives, most utterance-initial words (83.57 %) were function words. Conclusion These preliminary findings, although in need of replication with a larger sample size, seem to suggest that the word class (i.e., content/function words) contributions to stuttering loci are more language-specific whereas the word position (i.e., utterance-initial position) contributions to stuttering loci are more language-nonspecific. Given that the true characteristics of stuttering may be rather language-nonspecific than language-specific, further research may need to focus more on stuttering loci related to word position than word class.Background Brain metastases (BM) are common in patients with small cell lung cancer (SCLC). In recent years, the role of whole brain radiotherapy (WBRT) for brain metastases in lung cancer is being reevaluated, especially in the context of new systemic treatments available for SCLC. With this analysis, we investigate decision-making in SCLC patients with BM among European experts in medical oncology and radiation oncology. Methods We analyzed decision-making from 13 medical oncologists (selected by IASLC) and 13 radiation oncologists (selected by ESTRO) specialized in SCLC. Management strategies of individual experts were converted into decision trees and analyzed for consensus. Results and conclusion In asymptomatic patients, chemotherapy alone is the most commonly recommended first line treatment. In asymptomatic patients with limited volume of brain metastases, a higher preference for chemotherapy without WBRT among medical oncologists compared to radiation oncologists was observed. For symptomatic patients, WBRT followed by chemotherapy was recommended most commonly. For limited extent of BM in symptomatic patients, some experts chose stereotactic radiotherapy as an alternative to WBRT. Significant variation in clinical decision-making was observed among European SCLC experts for the first line treatment of patients with SCLC and BM.Although spatial navigation competence improves greatly from birth to adulthood, different spatial memory capacities emerge at different ages. Here, we characterized the capacity of 5-9-year-old children to use path integration to build egocentric and allocentric spatial representations to navigate in their environment, and compared their performance with that of young adults. First, blindfolded participants were tested on their ability to return to a starting point after being led on straight and two-legged paths. This egocentric homing task comprising angular and linear displacements allowed us to evaluate path integration capacities in absence of external landmarks. Second, we evaluated whether participants could use path integration, in absence of visual information, to create an allocentric spatial representation to navigate along novel paths between objects, and thus demonstrate the ability to build a cognitive map of their environment. Ninety percent of the 5-9-year-old children could use path integration to create an egocentric representation of their journey to return to a starting point, but they were overall less precise than adults. Sixty-four percent of 5-9-year-old children were capable of using path integration to build a cognitive map enabling them to take shortcuts, and task performance was not dependent on age. Imprecisions in novel paths made by the children who built a cognitive map could be explained by poorer integration of the experienced turns during the learning phase, as well as greater individual variability. In sum, these findings demonstrate that 5-9-year-old children can use path integration to build a cognitive map in absence of visual information.