stic role than RECIST 1.1.

The sum volumetric regression ratio and response based on RECIST 1.1 were related to the prognosis in locoregionally advanced NPC after induction chemotherapy. Sum volumetric regression ratio is an independent outcome predictor for survival in locoregionally advanced NPC, playing a better prognostic role than RECIST 1.1.

Aim of the study was to evaluate the prognostic impact of CD8-positive (CD8

) tumour-infiltrating lymphocytes (TILs) and PD-L1 expression on the outcome of patients with malignant salivary gland neoplasms.

Formalin-fixed, paraffin-embedded tissue samples and clinicopathological data from patients treated for salivary gland carcinoma in a head and neck cancer centre were retrospectively retrieved. Immunohistochemical staining was applied on sections of 84 specimens of 12 different histological subtypes. Both CD8 and PD-L1 expression were rated by semi-automated cell counts by a digital image analysis programme. Survival analyses were performed by the log-rank test on the univariate level, and the Cox model was applied on the multivariate level. Associations between immunological markers and clinicopathological variables were estimated by the Pearson chi-squared test. Additionally, PD-1 was estimated as an exhaustion marker of CD8

TILs.

Patients exceeding a tumour proportion score ≥5% regarding PD-L1 e these tumours and paves the way for future treatment strategies.

To determine genetic associations between oxcarbazepine (OXC)-induced maculopapular eruption (MPE) and human leukocyte antigen (HLA) variants in the Uighur Chinese population.

A total of 208 patients were enrolled in this study, including 20 subjects with OXC-induced MPE (case group) and 188 OXC-tolerant patients (control group). We detected the whole sequence of the HLA alleles in the 208 Uighur patients using next-generation sequencing (NGS).

The carried rate of HLA-A*0301 was significantly different between the OXC-induced MPE group and the tolerant group (7/20, 35% versus 4/188, 2.13%; P = 0.000, odds ratio [OR] = 24.77, 95% confidence interval [CI] = 6.41-95.65). read more Additionally, the carried rate of HLA-B*0702 was significantly different between the OXC-induced MPE group and the tolerant group (3/20, 15% versus 2/188, 0.011%; P = 0.000, odds ratio [OR] = 16.41, 95% confidence interval (CI) = 2.56-105.09).

HLA-A*0301 and HLA-B*0702 may be the risk alleles for MPE in the Uighur Chinese population.

HLA-A*0301 and HLA-B*0702 may be the risk alleles for MPE in the Uighur Chinese population.Since 2011, huge amounts of Sargassum algae are detected in the equatorial Atlantic, causing large strandings events on the coasts of the West Indies, Brazil and West Africa. The distribution of this stock shows strong annual and interannual variability, whose drivers are not settled yet. Here we use satellite Sargassum observations from MODIS and currents from an ocean reanalysis to simulate the passive transport of algae in 2017. Wind effect was necessary to fit the observed distribution. Simulations reasonably reproduce the satellite monthly distribution for up to seven months, confirming the prominent role of transport in the distribution cycle. Annual cycle appears as a zonal exchange between eastern (EAR) and western accumulation regions (WAR). EAR is well explained by advection alone, with sharp meridional distribution controlled by converging currents below the inter-tropical Convergence Zone. Instead, WAR is not explained by advection alone, suggesting local growth.Ostreopsis is a benthic dinoflagellate genus comprising eleven species including seven that are toxigenic. Ostreopsis lenticularis was first described from French Polynesia and is widely distributed in many insular locations from the Pacific Ocean. The current study presents morphological and molecular evidence of the presence of O. lenticularis at the Fernando de Noronha Archipelago, South Atlantic. Light microscopy and scanning electron microscopy of field cells showed morphological features in agreement with the description of O. lenticularis. Cells were broadly oval, 66.0-117.5 μm in dorso-ventral diameter, 50.0-92.5 μm in width, with thecal plates presenting two kinds of pores. Phylogenetic analyses based on LSU (D1-D3) and ITS sequences from field cells from Fernando de Noronha clustered with O. lenticularis sequences from elsewhere. The species was present in low to high abundances. The current study expands the distribution of O. lenticularis to Fernando de Noronha Archipelago in the South Atlantic Ocean.This paper responds to the increasing concern regarding the role of non-human life in shaping urban space by exploring the public perception of urban companion animals during the coronavirus disease 2019 (COVID-19) outbreak in China. We argue that the public’s perception of urban companion animals during emerging infectious disease outbreaks is related to medical and life science issues and reflects the political, economic, and emotional struggles involved in human-animal multispecies cohabitation. We find that the public has mainly followed and reconstructed medical discourses about the risk of companion animal-to-human transmission and discussed sustainable ethical animal practices in urban public health emergency management during the COVID-19 outbreak. Concerns regarding the risk of companion animal-related infection reflect the increasing prominence of more-than-human families, the pet industry, and multispecies leisure conflicts in public space in Chinese cities. The public’s attention to animal ethics has prompted Chinese policy makers to adopt a more morally acceptable model for urban public health emergency management that can be sustained and supported by responsible non-governmental organizations and ethical urban residents.Cochlear implant (CI) candidates with residual low-frequency hearing are nowadays often implanted with CI electrode arrays that allow preserving their acoustic hearing in the implanted ear. These subjects receiving combined electric-acoustic stimulation (EAS) show enhanced speech perception scores when compared to traditional CI users without acoustic component. However, these benefits are limited by interaction effects such as masking between electric and acoustic stimulation. This study evaluates ipsilateral electric-acoustic masking in a psychophysical experiment conducted in 5 EAS subjects. The elevation of acoustic pure tone thresholds through simultaneous presentation of electric pulse trains and vice versa is measured for different acoustic frequencies and different settings of the electric stimuli. Electric-acoustic interaction could originate either from electroneural stimulation of auditory nerve fibers or from electrophonic stimulation of hair cells. The two fundamental goals of this study are to investigate the effects of stimulation rate and phase duration of the electric stimulus on electric-acoustic masking and to investigate the origin of electric-acoustic masking by assessing the contributions of electroneural versus electrophonic stimulation.