These results demonstrate that the PTSHPβCD complex has a dose-dependent antioxidant mechanism that results in improved cardiac function in experimental right heart failure. Our results open a field of possibilities to PTS administration as new therapeutic approach to conventional therapy for right ventricular dysfunction. Novelty bullets – Pterostilbene complexed with hydroxypropyl-β-cyclodextrin could be a new therapeutic approach; – Pterostilbene complexed with hydroxypropyl-β-cyclodextrin re-establishes redox homeostasis, through glutathione metabolism modulation, leading to an improved myocardial performance index in pulmonary arterial hypertension-provoked right heart failure.Pneumolysin (Ply) is a major virulence factor of in epithelial cells.Peroxisomes are organelles in eukaryotic cells responsible for processing several types of lipids and managing reactive oxygen species. A conserved family of peroxisome biogenesis (Peroxin, Pex) genes encode proteins essential to peroxisome biogenesis and function. In yeast and mammals, PEROXIN7 (PEX7) acts as a cytosolic receptor protein that targets enzymes containing a peroxisome targeting sequence 2 (PTS2) motif for peroxisome matrix import. The PTS2 motif is not present in the Drosophila melanogaster homologs of these enzymes. However, the fly genome contains a Pex7 gene (CG6486) that is very similar to yeast and human PEX7. We find that Pex7 is expressed in tissue-specific patterns analogous to differentiating neuroblasts in D. melanogaster embryos. This is correlated with a requirement for Pex7 in this cell lineage as targeted somatic Pex7 knockout in embryonic neuroblasts reduced survival. We also found that Pex7 over-expression in the same cell lineages caused lethality during the larval stage. Targeted somatic over-expression of a Pex7 transgene in neuroblasts of Pex7 homozygous null mutants resulted in a semi-lethal phenotype similar to targeted Pex7 knockout. These findings suggest that D. melanogaster has tissue-specific requirements for Pex7 during embryo development.Brain‑type glycogen phosphorylase (PYGB) has been indicated to be correlated with the progression of various human malignancies. However, its effect and regulatory mechanism in non-small cell lung cancer (NSCLC) are still unclear. Western blotting, immunohistochemistry and qRT-PCR verified that PYGB protein and mRNA expression was up-regulated in both NSCLC cell lines and tissues. Its expression was positively related to TNM stage, positive lymph node metastasis and poor prognosis in NSCLC patients. Moreover, overexpression of PYGB promoted cell proliferation, migration, and invasion but inhibited apoptosis in vitro. Immunofluorescence (IF) assay showed that overexpression PYGB promoted β-catenin nuclear import and accumulation. On the contrary, silencing of PYGB showed reversed effects. Besides, PYGB overexpression also activated Wnt pathway and Sh-PYGB showed the opposite results, which were abrogated by XAV-939 (a β-catenin Inhibitor) or overexpression of β-catenin, respectively. Finally, PYGB knockdown inhibited tumor growth in xenograft mice. These findings clarified the biologic significance of PYGB in NSCLC progression and revealed a link between PYGB and Wnt/β-catenin pathway, which thus provided a new potential target for clinical therapy of NSCLC.The presence of anthropogenic nanoparticles (NPs) in the aquatic environment has become an emerging concern in terms of environmental and health safety. In the present study, we assessed the presence of Ag-bearing, Ti-bearing, and Ce-bearing NPs in the Barcelona catchment area, including the Besòs River basin and the Barcelona coast, and in the Ebro River Delta, using single particle inductively coupled plasma mass spectrometry (sp-ICP-MS). Ti-NPs and Ce-NPs were ubiquitously detected in surface waters, and their presence was related to a high natural background. Concentrations of Ti-NPs ranged from 23.2 × 106 to 298 × 106 Ti-NPs/L, with high concentrations being detected in areas with little anthropogenic pressure, while the presence of nanosilver (17.9 × 106 to 45.1 × 106 Ag-NPs/L) in the analyzed rivers was limited to certain hotspots close to wastewater treatment plants discharge points. The concentrations of Ce-NPs in the river ranged from 18.1 × 106 to 278 × 106 NPs/L, and they were related to the natural occurrence of the mineral Monazite-(Ce). Overall, the concentrations of these nanomaterials in the Barcelonan coast were significantly attenuated by river-sea environmental dilution. Nevertheless, Ce-NPs were eventually detected in some seawater samples with low levels of lanthanum-NPs, suggesting anthropogenic inputs of nanoCeO2, probably from atmospheric deposition.We report the conversion of aryl methyl ethers and phenols into six fluoroalkyl analogues through late-stage functionalization of a natural product-derived FDA-approved therapeutic. This series of short synthetic sequences exploits a combination of both modern and traditional methods and demonstrates that some recently reported methods do not always work as well as desired on a natural product-like scaffold. Methylation inhibitor Nonetheless, reaction optimization can deliver sufficient quantities of each target analogue for medicinal chemistry purposes. In some cases, classical reactions and synthetic sequences still outcompete modern organofluorine transformations, which should encourage the continued search for improved reactions. Overall, the project provides a valuable synthetic roadmap for medicinal chemists to access a range of fluorinated therapeutic candidates with distinct physicochemical properties relative to the original O-based analogue.Redox-active metal oxide nanoparticles show varying oxidizing capacities and injury potentials toward biological systems. Here, two metal oxide libraries including transition-metal-doped Co3O4 and PdO-Co3O4 with strong chemical contacts were design-synthesized and used to investigate their biological injury potential and mechanisms using zebrafish as a model organism. Among different dopants, Cu significantly increased the oxidizing capacity of Co3O4. An increased amount of PdO resulted in higher density of heterojunctions, which also led to higher oxidizing capacity. The oxidizing capacity of these nanoparticles was positively correlated with higher mortality of dechorionated embryos and severe larval skin injury upon exposure. Using transgenic zebrafish Tg(LysCeGFP), we show in real time that the redox-active nanoparticles induced skin injury and activated the infiltration of immune cells. Such inflammatory response was confirmed by the increased mRNA expression level of Nrf2a, HO-1, IL-1β, and IL-6 genes. Although the exposure to the nanoparticles alone was not lethal, the skin injury did lower the tolerance level against other environmental contaminants.