Abnormal samples, and it’s discriminatory components, were also explored. In summary, the established fingerprinting method with multivariate statistical analysis, could offer an efficient, reliable, and practical approach for quality consistency evaluation of Transfer Factor injection, providing a reference for the quality control of other multi-component biochemical drugs. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Is It Possible to Obtain Solvent-Free, Li+ -Conducting Solid Electrolytes Based on Pure PVdF? Comment on “Self-Suppression of Lithium Dendrite in All-Solid-State Lithium Metal Batteries with Poly(vinylidene difluoride)-Based Solid Electrolytes”. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.NEW FINDINGS What is the topic of this review? Right heart dysfunction remains a major adverse event in patients with end stage heart failure undergoing left ventricular assist device placement. This article reviews the pathophysiology and clinical considerations of right heart failure in this patient population. What advances does it highlight? This review highlights the anatomic and physiological peculiarities of the interplay between left and right heart function in patients undergoing LVAD therapy. These would allow us to further advance our understanding of right ventricular function. ABSTRACT The adaptation of the right ventricular (RV) output to a left ventricular assist device (LVAD) often determines the fate of patients with pulmonary hypertension secondary to left heart failure. Pre-existing right heart dysfunction in patients with advanced left heart failure is the consequence of increased (arterial) afterload and not simply the consequence of myocardial disease. If unaccounted for, it has the potential of accelerating into clinical right heart failure after LVAD, leading to significant morbidity and mortality. After LVAD implantation, the RV has to face increased flow generated by the LVAD, cardiac arrhythmias and exaggerated functional interactions between both ventricles. Understanding the key physiological mechanisms of RV dysfunction in patients with end-stage heart failure will allow us to predict and therefore prevent RV failure after LVAD implantation. © 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.Platelet-rich plasma (PRP) is a platelet concentrate obtained from whole blood centrifugation. The use of PRP in hair transplants (HT) has suggested better postoperative recovery with less erythema and crust formation, faster and better growth of transplanted follicular units (FU). A retrospective study was performed evaluating all male patients with AGA who underwent HT using the strip technique (FUT), from March 2013 to March 2016, in the same service in Brazil. Cases were defined as patients receiving PRP (n=169) and who did not receive PRP (n=65), control group. This article is protected by copyright. All rights reserved.This study provided the benchmark statistics on medically treated patients with non-small cell (NSCLC) and small cell (SCLC) lung cancer in Japan. Demographic background, treatment, and prognosis were obtained from patients with lung cancer pathologically diagnosed in 2012, who received non-surgical treatment. Descriptive statistics and their associations with survival were analyzed. A total of 12320 patients were registered from 314 institutions in Japan. The median age was 70 years, and 73% of the patients were male. The number (%) of stage I, II, III, IV diseases were 468 (3.8%), 421 (3.4%), 3260 (26.5%), and 8171 (66.3%), respectively. NSCLC and SCLC accounted for 9872 (80.1%) and 2353 (19.1%) patients, respectively. Thoracic radiotherapy-based therapy, chemotherapy, and palliative care alone were administered to 2572 (20.9%), 7790 (63.2%), and 1952 (15.8%) patients, respectively. Clinical TNM stage was one of the strongest prognostic factors with the 3-year survival rates of 62.9%, 47.3%, 40.0%, 27.8%, 37.5%, 26.5%, and 18.2% for stage IA, IB, IIA, IIB, IIIA, IIIB, and IV, respectively. Among 6158 NSCLC patients treated with chemotherapy, the 3-year survival rate was 33.4% in patients receiving epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) at some point in their clinical course, whereas it was 17.4% in patients who did not. Folinic The 3-year survival rate of SCLC was only 15.9%. In conclusion, approximately two-thirds of the patients were diagnosed as stage IV at the initial diagnosis. Use of EGFR-TKIs significantly improved the survival of patients with NSCLC. This article is protected by copyright. All rights reserved.Skin hyperpigmentation is of great concern to people who suffer from it. It may be endogenous (when the pigments are formed within the body) or exogenous (when the pigments are applied externally, for example tattoos). The main endogenous pigments are melanin (e.g. melanocytic nevi, lentigines) and hemosiderin (dermite ocre). The activation of melanocytes, due to pregnancy hormones, sunlight, or local inflammations, causes an increase in the melanin production. Hemosiderin deposition can be caused by an increased hydrostatic pressure (such as during chronic venous insufficiency), vasculitis of small skin vessels, or vessel destruction (resulting from sclerotherapy, post-surgical hematoma formation, and skin-laser therapy). This article is protected by copyright. All rights reserved.PURPOSE To provide a rapid, noninvasive fat-water separation technique that allows producing quantitative maps of particular lipid components. METHODS The calf muscles in 5 healthy adolescents (age 12-16 years; body mass index = 20 ± 3 kg/m2 ) were scanned by two different fat fraction measurement methods. A density-weighted concentric-ring trajectory metabolite-cycling MRSI technique was implemented to collect data with a nominal resolution of 0.25 mL within 3 minutes and 16 seconds. For comparative purposes, the standard Dixon technique was performed. The two techniques were compared using structural similarity analysis. Additionally, the difference in the distribution of each lipid over the adolescent calf muscles was assessed based on the MRSI data. RESULTS The proposed MRSI technique provided individual fat fraction maps for eight musculoskeletal lipid components identified by LCModel analysis (IMC/L [CH3 ], EMCL [CH3 ], IMC/L [CH2 ]n , EMC/L [CH2 ]n , IMC/L [CH2 -CH], EMC/L [CH2 -CH], IMC/L [-CH=CH-], and EMC/L [-CH=CH-]) with mean structural similarity indices of 0.