with changes in dental morphology patterns, suggesting its adoption is not exclusively associated with the arrival of different biological groups. Southeast coastal and riverine groups show high phenotypic diversity, suggesting a different history of human occupation and cultural development than observed in the South Coast.

Misophonia is a highly prevalent yet understudied condition characterized by aversion toward particular environmental sounds. Oral/nasal sounds (e.g., chewing, breathing) have been the focus of research, but variable experiences warrant an objective investigation. Experiment 1 asked whether human-produced oral/nasal sounds were more aversive than human-produced nonoral/nasal sounds and non-human/nature sounds. Experiment 2 additionally asked whether machine-learning algorithms could predict the presence and severity of misophonia.

Sounds were presented to individuals with misophonia (Exp.1 N = 48, Exp.2 N = 45) and members of the general population (Exp.1 N = 39, Exp.2 N = 61). Aversiveness ratings to each sound were self-reported.

Sounds from all three source categories-not just oral/nasal sounds-were rated as significantly more aversive to individuals with misophonia than controls. Further, modeling all sources classified misophonia with 89% accuracy and significantly predicted misophonia severity (r = 0.75).

Misophonia should be conceptualized as more than an aversion to oral/nasal sounds, which has implications for future diagnostics and experimental consistency moving forward.

Misophonia should be conceptualized as more than an aversion to oral/nasal sounds, which has implications for future diagnostics and experimental consistency moving forward.This paper draws on the concepts and tools of Pierre Bourdieu to construct a comprehensive model of the contemporary British “food space.” It uses multiple correspondence analysis to unearth a space structured in two key dimensions revolving around the lean and the rich. A host of supplementary variables are available to examine the relationship, or homology, between food tastes and broader alimentary dispositions, including orientations toward shopping, ethics and cooking. Indicators of social position reveal the structuring of the space by economic and cultural capital as well as gender, but also, updating and nuancing Bourdieu’s own model for 1970s’ France, by age, region, ethnicity and religion. Finally, the paper examines the relationship between position in the food space and physical, mental and existential wellbeing, demonstrating that orientation toward the less healthy and the less rich, corresponding with few resources, is, in some cases, accompanied by not only hunger and deprivation but profound worry and misery.

To evaluate the impact of fremanezumab on the severity and duration of remaining migraine attacks in patients with chronic migraine (CM) or episodic migraine (EM).

Fremanezumab is a fully humanized monoclonal antibody (IgGΔa) that selectively targets calcitonin gene-related peptide and is efficacious in reducing migraine frequency.

This exploratory post hoc analysis included data from three randomized, double-blind, 12-week, phase 3 studies (HALO CM, HALO EM, and FOCUS). In all three studies, patients with CM or EM were randomized 111 to receive subcutaneous quarterly fremanezumab (month 1/2/3 675mg/placebo/placebo), monthly fremanezumab (month 1/2/3 675mg [CM], 225mg [EM]/225mg/225mg), or matched monthly placebo. Changes from baseline were evaluated in the proportion of headache days of at least moderate severity, peak severity of headache days, mean monthly headache hours (of any severity and at least moderate severity), and mean headache hours per headache day of any severity.

A total of 2843 patiein patients with CM or EM, including in patients with documented inadequate response to two to four prior migraine preventive medication classes.

These analyses demonstrated that quarterly or monthly treatment with fremanezumab significantly reduced headache severity and duration in patients with CM or EM, including in patients with documented inadequate response to two to four prior migraine preventive medication classes.

Patients with locally advanced pancreatic cancer (LAPC) are increasingly treated with FOLFIRINOX, resulting in improved survival and resection of tumors that were initially unresectable. It remains unclear, however, which specific patients benefit from FOLFIRINOX. Two nomograms were developed predicting overall survival (OS) and resection at the start of FOLFIRINOX for LAPC.

From our multicenter, prospective LAPC registry in 14 Dutch hospitals, LAPC patients starting first-line FOLFIRINOX (April 2015-December 2017) were included. Stepwise backward selection according to the Akaike Information Criterion was used to identify independent baseline predictors for OS and resection. Two prognostic nomograms were generated.

A total of 252 patients were included, with a median OS of 14 months. Thirty-two patients (13%) underwent resection, with a median OS of 23 months. click here Older age, female sex, Charlson Comorbidity Index ≤1, and CA 19.9 < 274 were independent factors predicting a better OS (c-index 0.61). WHO ps >1, involvement of thesuperior mesenteric artery, celiac trunk, and superior mesenteric vein ≥ 270° were independent factors decreasing the probability of resection (c-index 0.79).

Two nomograms were developed to predict OS and resection in patients with LAPC before starting treatment with FOLFIRINOX. These nomograms could be beneficial in the shared decision-making process and counseling of these patients.

Two nomograms were developed to predict OS and resection in patients with LAPC before starting treatment with FOLFIRINOX. These nomograms could be beneficial in the shared decision-making process and counseling of these patients.

In 2016, the Act on Decisions on Life-Sustaining Treatment for Patients in Hospice and Palliative Care was implemented in Korea, providing a broad framework for end-of-life decision-making for the first time and making advance directives legally recognized documents. This Act can correct long-standing under-recognition of patients as valid decision makers for their own treatment choices. However, limited recognition of patient self-determination, rigid legal forms for documenting patient wishes, and the roles of family under the Act may pose challenges both to patients and nurses.

This paper critiques whether this newly introduced system of advance directives can truly guarantee protection of the patient’s interests and respect for patient autonomy in real life​, and discusses ethical and legal issues regarding the Act.

We reviewed the current system of advance directives by raising three questions (1) Do advance directives reflect a competent person’s voluntary and informed choice?, (2) Are advance directives applicable in diverse clinical situations?, and (3) Does the Korean advance directive system ensure that such directives are honored in reality?

Although the Act is an important first step in respecting patient autonomy in end-of-life decision-making, it remains inadequate as it fails to provide thorough guidance in terms of the quality of writing process, applicability, and the guaranteed effects of advance directives.