Trichophyton violaceum is the most common dermatophyte species in most regions while adult tinea capitis caused by Microsporum canis is less common. Terbinafine, griseofulvin and itroconazole have been reported to be effective drugs for the treatment of tinea capitis, and terbinafine can be considered as systemic treatment in elderly patients with comorbidities to reduce the drug-drug interaction.

Obesity, measured by body mass index (BMI), is implicated in adverse pregnancy outcomes for women seeking in vitro fertilization (IVF) care. However, the shape of the dose-response relationship between BMI and IVF outcomes remains unclear.

We therefore conducted a dose-response meta-analysis using a random effects model to estimate summary relative risk (RR) for clinical pregnancy (CPR), live birth (LBR), and miscarriage risk (MR) after IVF.

A total of 18 cohort-based studies involving 975,889 cycles were included. For each 5-unit increase in BMI, the summary RR was 0.95 (95% CI 0.94-0.97) for CPR, 0.93 (95% CI 0.92-0.95) for LBR, and 1.09 (95% CI 1.05-1.12) for MR. There was evidence of a non-linear association between BMI and CPR (P

< 10

) with CPR decreasing sharply among obese women (BMI > 30). Non-linear dose-response meta-analysis showed a relatively flat curve over a broad range of BMI from 16 to 30 for LBR (P

= 0.0009). In addition, we observed a J-shaped association between BMI and MR (P

= 0.006) with the lowest miscarriage risk observed with a BMI of 22-25.

In conclusion, obesity contributed to increased risk of adverse IVF outcomes in a non-linear dose-response manner. More prospective trials in evaluating the effect of body weight control are necessary.

In conclusion, obesity contributed to increased risk of adverse IVF outcomes in a non-linear dose-response manner. More prospective trials in evaluating the effect of body weight control are necessary.Coal is the most aggressive energy sources in the environment. Several adverse outcomes on children’s health exposure to coal pollutants have been reported. Pollutants from coal power plants adversely affect the intellectual development and capacity. The present study aimed to evaluate the intellectual development and associated factors among children living a city under the direct influence (DI) and six neighboring municipalities under the indirect influence (II) of coal mining activity in the largest coal reserve of Brazil. A structured questionnaire was completed by the child’s guardian, and Raven’s Progressive Color Matrices were administered to each child to assess intellectual development. A total of 778 children participated. In general, no significant difference was observed between the two cities. The DI city had better socioeconomic conditions than the II municipalities according to family income ( 0.05) between municipalities. In both unadjusted and adjusted analyses, intellectual development was associated with maternal age, marital situation and maternal education level, birth weight, breast feeding, frequent children’s daycare, paternal participation in children’s care and child growth. Living in the DI area was not associated with intellectual disability. The results suggest that socioeconomic conditions and maternal and neonatal outcomes are more important than environmental factors for intellectual development of children living in a coal mining area.The dietary composition of fish constitutes numerous immune and growth-promoting substance; during the current study, methionine was amended in the diet of Labeo rohita (L. rohita), in order to appraise the diverse modulatory effects of methionine supplementation. Fish were grouped into three on the basis of methionine as methionine supplemented group 1 (MSG1), methionine supplemented group 2 (MSG2), and CTRL (control group). We assessed the effects of methionine at the end. Captivating results were obtained from the methionine supplementing groups. The results depict significantly high (p less then 0.05) innate immunity parameters, including myeloperoxidase, IgG concentrations, lysozyme, respiratory burst, and total bacteriolytic activity of complement in MSG2. Furthermore, ameliorate growth performances were also noticed such as high weight gain, FCE%, and body length in MSG2, respectively. We also measured high level of antioxidant digestive enzymes, gut length, and survival rate in MSG2 compared to the rest of the groups. The results were further validated by measuring the stress parameters, such as aspartate aminotransferase (AST), glucose, and hematocrit (HCT%), and the concentration remains low in MSG2. Lastly, after 90 days, fish were challenged with Aeromonas hydrophila, the highest survival was observed in the MSG2 and MSG1 compared to CTRL. These results ultimately give the baseline to the credible effects of methionine on L. rohita.To evaluate implant loss (IL) and marginal bone loss (MBL); follow-up period of up to 10 years after prosthetic loading. Retrospective multi-centre cross-sectional cohort study. Double analysis (1) all the implants (n = 456) were analysed; (2) to allow for possible cluster error, one implant per patient (n = 143) was selected randomly. Statistical analysis Spearman’s correlation coefficient; Kruskal-Wallis (post-hoc U-Mann-Whitney); Chi-square (post-hoc Haberman). (1) Analysing all the implants (456) IL was observed in patients with past periodontitis (6 vs. 2.2%, p  less then  0.05), short implants (12 vs. 2.8%, p  less then  0.001) and when using regenerative surgery (11.3 vs. 2.9%, p  less then  0.001); greater MBL was observed among smokers (0.39 ± 0.52 vs. 0.2 ± 0.29, p  less then  0.01), maxillary implants (0.28 ± 0.37 vs. 0.1 ± 0.17, p  less then  0.0001), anterior region implants (0.32 ± 0.36 vs. 0.21 ± 0.33, p  less then  0.001), external connection implants (0.2 ± 0.29 vs. 0.63 ± 0.59, p  less then  0.0001), and 2-3 years after loading (p  less then  0.0001). (2) analysing the cluster (143) IL was observed in smokers (18.8 vs. 3.5%, p  less then  0.05), splinted fixed crowns (12.9%, p  less then  0.01), short implants (22.2 vs. 4.0%, p  less then  0.01) and when using regenerative surgery (19.2 vs. 3.4%, p  less then  0.01); greater MBL was observed in maxillary implants (0.25 ± 0.35 vs. selleck chemicals 0.11 ± 0.18, p  less then  0.05), in the anterior region (p  less then  0.05), in the first 3 years (p  less then  0.01), in external connection implants (0.72 ± 0.71 vs. 0.19 ± 0.26, p  less then  0.01) and in short implants (0.38 ± 0.31 vs. 0.2 ± 0.32, p  less then  0.05). There is greater risk in smokers, patients with past periodontal disease, external connection implants, the use of short implants and when regenerative techniques are used. To prevent MBL and IL, implantologists should be very meticulous in indicating implants in patients affected by these host factors.