Moreover, the p38 MAPK signaling pathway and ROS production were activated upon stimulation with a miR-146a-5p mimic. However, treatment with a miR-146a-5p inhibitor decreased the levels of APP, ROS, and p-p38 MAPK. A similar phenomenon was also observed in the animals treated with Aβ

, in which miR-146a upregulation increased the expression of Aβ, p-p38, and ROS, while the inhibition of miR-146a had the opposite effect. This suggests that miR-146a increases Aβ deposition and ROS accumulation via the p-p38 signaling pathway.

Our research demonstrates that miR-146a-5pa increases Aβ deposition by triggering oxidative stress through activation of MAPK signaling.

Our research demonstrates that miR-146a-5pa increases Aβ deposition by triggering oxidative stress through activation of MAPK signaling.

The COVID-19 pandemic has had an impact on ischaemic stroke management, with a reported decrease in hospital admissions, and even disruptions in healthcare and increased in-hospital mortality. However, there is a lack of evidence on the impact of the pandemic on functional prognosis. The aim of this study is to analyse the effect of the COVID-19 pandemic on the 3-month functional outcomes of patients hospitalised due to acute ischaemic stroke in Aragon (Spain).

We reviewed the data of all patients admitted due to ischaemic stroke to any hospital in our regional healthcare system between 30 December 2019 and 3 May 2020. We compared modified Rankin Scale scores and mortality at 3 months in patients hospitalised before and after the declaration of a state of emergency due to the COVID-19 pandemic.

In total, 318 patients with acute ischaemic stroke met our inclusion criteria. No differences were observed between periods in global or specific characteristics, with the exception of a higher proportion of patients older than 80 years during the first period (42.2% vs. 29.0%, P=.028). In the comparative analysis, we found no significant differences in mortality (12.3 vs. 7.9, P=.465) or in the proportion of patients with modified Rankin Scale scores ≤ 2 (57.7% vs. 57.1%, P=.425) at 3 months.

To our knowledge, this is the first study to analyse the impact of COVID-19 pandemic on the 3-month functional outcomes of patients with ischaemic stroke. In our region, there has been no increase in rates of mortality or disability at 3 months in patients admitted due to ischaemic stroke during the pandemic.

To our knowledge, this is the first study to analyse the impact of COVID-19 pandemic on the 3-month functional outcomes of patients with ischaemic stroke. In our region, there has been no increase in rates of mortality or disability at 3 months in patients admitted due to ischaemic stroke during the pandemic.

Currently, the lack of tools for physiotherapists, and the quality of these tools when physiotherapists assess patients does not allow a good diagnosis. Accurate joint range evaluation is an essential task in the daily work of physiotherapists in order to correctly assess treatment progress. In this study, we examined the reliability and safety of an Android system application called G-Pro to evaluate its characteristics and observe its usefulness as a goniometer to measure joint angles in a clinic.

The standard goniometer and G-pro smartphone with the application were used to passively and bilaterally measure shoulder flexion and rotation and elbow flexion in 30 participants able to tolerate standing.

The G-pro smartphone application showed good to excellent reliability (r=0.998 to 0.896, P<.01), while the universal goniometer showed acceptable to questionable reliability (r=0.757 to 0.609) in active shoulder flexion-extension movement.

The results obtained in this study show that these devices represent an additional resource to assess joint mobility ranges. Due to technological progress, we can improve, innovate, and demonstrate the results of joint assessments to ensure their accuracy. This, in turn, ensures that the treatment provided is appropriate and specific to each patient. This tool is low cost and is accessible for health care professionals; moreover, it is easy to use since it has an incliniometer that is reliable both visually and evaluatively.

The results obtained in this study show that these devices represent an additional resource to assess joint mobility ranges. Due to technological progress, we can improve, innovate, and demonstrate the results of joint assessments to ensure their accuracy. This, in turn, ensures that the treatment provided is appropriate and specific to each patient. This tool is low cost and is accessible for health care professionals; moreover, it is easy to use since it has an incliniometer that is reliable both visually and evaluatively.

Infections related to non-surgical manipulation of the biliary tract (NSMBT) are common events despite periprocedural antibiotic prophylaxis (PAP). Selleckchem SL-327 Since June 2017, our local protocol has indicated a 24-h regimen of intravenous piperacillin-tazobactam for this purpose.

We aimed to describe the incidence and characteristics of NSMBT-related paediatric infections, define risk factors for their development, and analyse adherence to our PAP protocol.

Epidemiological, clinical, and microbiological data were collected in consecutive NSMBT procedures performed in paediatric patients (<18 years) in our centre (2010-2019).

113 procedures in 37 patients, median age 4 years (IQR 1-8), were included. Main underlying diseases were biliary atresia (32%) and cancer (14%). Sixty-eight percent had undergone liver transplant and 70% hepaticojejunostomy. In 44 procedures (39%), the intervention was performed during the course of infection and previously prescribed antibiotic treatment was maintained. In the other 69,After establishing a PAP protocol, 100% of interventions received appropriate prophylaxis, decreasing antibiotic exposure time and potentially, the length of hospital stay.Providing long-term care (LTC) to the elderly is a major challenge for the welfare state. LTC systems differ widely among countries. Due to recent maturation, economization, and marketization processes, earlier LTC comparisons and typologies are no longer suitable to give a comprehensive overview of LTC systems and their major characteristics. In this paper we introduce a new typology of LTC systems in the OECD world, based on most recent OECD data and a unique set of institutional indicators. This typology aims to make LTC systems more comparable to welfare state and healthcare system typologies and thereby improve our understanding of how LTC is embedded in the wider welfare state and how it is related to other welfare state institutions. Based on 24 cluster analyses, we identify six (method-driven) and nine (content-driven) LTC types, which can be adapted in future studies according to the needs. In the six-types solution, we suggest a public supply type (e.g., Sweden), a private supply type (e.g., Germany), a residual public type (e.