The expression of these proteins was examined at transcriptional level and similar results were obtained. Inhibited expression of these proteins and related pathways contributed to the observed decrease in the grain filling rate of Zhefu802, and application of SA up-regulated expression of these proteins to improve grain weight. The findings of this study provide new insights into grain filling regulation by SA, and offer the scientific foundation for cultivation practice. Arsenic contamination has attracted worldwide concerns, owing to its toxicity and severe threat to human and environment. It is urgent to develop efficient adsorbents to remove arsenic pollutants. Within this paper, both pristine MIL-88A(Fe) and MIL-88A(Fe) decorated on cotton fibers were successfully fabricated using an eco-friendly method. see more The pristine MIL-88A(Fe) displayed outstanding adsorption performances towards four selected arsenic pollutants, in which the adsorption capacities toward As(III), As(V), ROX and ASA were 126.5, 164.0, 261.4 and 427.5 mg g-1, respectively. Additionally, MIL-88A(Fe) exhibited excellent removal efficiencies in a wide pH range and with the presence of different co-existing ions. It was proposed that the coordinative interactions of As-O-Fe between arsenic pollutants and MIL-88A(Fe) contributed to the superior adsorption performances. Furthermore, two MIL-88A(Fe)/cotton fibers composites were synthesized by both post synthesis (MC-1) and in-situ synthesis (MC-2), which demonstrated identically outstanding adsorption activities toward four selected arsenic pollutants. MC-1 and MC-2 enhanced the stability and reusability of MIL-88A(Fe), which was challenging issues of pristine MIL-88A(Fe) powder. Additionally, the fixed-bed column packed by MC-1 or MC-2 can continuously eliminate arsenic pollutants from the water flow. This work provided a new possibility of metal-organic frameworks to accomplish potentially large-scale application to purify the arsenic-contaminated water. Bisphenol A (BPA), a well-known endocrine disruptor, was reported to promote migration and invasion of lung cancer cells, but findings in human study is absent. A case-control study in Chinese population was conducted to evaluate the association between BPA exposure and non-small cell lung cancer (NSCLC), and explore the interaction between BPA exposure and estrogen-related genetic polymorphism on NSCLC. BPA concentrations were measured in urine samples using an UHPLC-MS method and rs2046210 in estrogen receptor α (ESR1) gene was genotyped by TaqMan genotyping system. Logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (95% CI) for the association analyses. As a result, 615 NSCLC cases and 615 healthy controls were enrolled from Wuhan, central China. The mean age was 58.0 (SD 7.9) years old for controls and 59.2 (SD 8.8) years old for cancer cases. The creatinine-adjusted BPA levels were significantly higher in NSCLC cases than that in healthy controls (median 0.97 vs 0.73 μg/L, P  less then  0.001). Exposure to high levels of BPA was significantly associated with NSCLC (adjusted OR = 1.91, 95%CI 1.39-2.62, P  less then  0.001 for the highest quartile). We also observed a shallow concave dose-response relationship about the overall association between BPA and NSCLC. Moreover, interaction analyses showed that BPA exposure interacted multiplicatively with rs2046210, with a marginal P value (P = 0.049), to contribute to NSCLC. In conclusion, exposure to high levels BPA may be associated with NSCLC and the relationship may be modified by genetic polymorphism in ESR1. Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are typical per- and poly-fluorinated alkyl substances (PFASs) that epidemiological studies have already associated with diabetes. However, insufficient data on their toxicity have been reported to explain any mechanism of action, which could justify such an association. Meanwhile, short-chain PFASs designed to substitute PFOA and PFOS, have already raised increasing concerns for their biosafety. Here, we evaluated whether common PFASs affected pancreatic and endocrine cell development using a human pluripotent stem cell pancreatic induction model and human pancreatic progenitor cell (hPP) endocrine induction model. The short-chain PFASs, pentafluorobenzoic acid, perfluorohexanoic acid, perfluorobutanesulfonic acid, and perfluorohexanesulfonic acid, homologous to PFOA or PFOS, did not significantly disrupt hPP generation, unlike PFOA and PFOS, based on pancreatic and duodenal homeobox 1 (PDX1) expression. However, SRY box 9 (SOX9) expression was suppressed in PDX1+ hPPs. All six PFASs did not disrupt SOX9 expression or hPP proliferation. However, endocrine differentiation of hPPs was affected, as indicated by neurogenin-3 (NGN3) downregulation, owing to abnormal increases in SOX9 and hairy and enhancer of split-1 (HES1) expressions. Thus, hyperactivation of NOTCH signaling was repressed after hPPs committed to the endocrine lineage. In conclusion, our study demonstrates how powerful human pluripotent stem cell-based pancreatic differentiation models can be in developmental toxicity evaluations, compared to traditional toxicity assays, mostly based on live animals. Moreover, our findings suggest that PFASs may alter pancreatic development after the pancreatic domain emerges from the gut tube, and provide insights into their toxicity mechanisms. The remediation of cadmium-pyrene co-contaminated soil by electrokinetic (EK) and the influence factors were investigated in this study. The artificial contaminated soils were treated for 20 days in EK experimental setups without electrolyte solution reservoirs, to simulate in-situ remediation of unsaturated soil. The results indicated that polarity-reversing electric field had maintained soil pH in the range of 7.27-7.67. Cadmium (Cd) contaminant would aggregate near electrodes, and the average Cd concentration in these areas had reached 72.21 mg/kg (original 51.6 mg/kg), while the value in soil farthest away from electrodes was 33.58 mg/kg. The reasons for Cd aggregated were the insoluble hydroxide formations attribute to the frequently alternation of acid-base environment, and the decrease of pH and water holding capacity in soil away from electrodes would promote the dissolved Cd movement by electro-osmosis flow. Although the applied electric field could promote the growth and activity of pyrene-degrading microorganisms (PDM), the soluble Cd would be the restriction factor, especially in soil near electrodes.