Among 142 patients sixty-three (44%) patients had an aortic valve intervention in a follow-up (median – 208 days; lower – upper quartile, 73 – 531 days). Based on the result of DSE test, severe AS was significantly more often associated with qualification to intervention compared to the moderate and pseudo-severe subgroups (P < 0.0001).

DSE test in severe AS is a valuable diagnostic tool in patients with LG AS in Poland.

DSE test in severe AS is a valuable diagnostic tool in patients with LG AS in Poland.Pulmonary arterial hypertension (PAH) is a rare disease characterized by pulmonary vascular remodeling leading to increased vascular resistance. The increased afterload contributes to the development of right ventricular dysfunction and heart failure, which is the leading cause of death among patients with PAH. The development of specific treatments has markedly improved the prognosis of this population. However, PAH continues to be an incurable, life‑limiting condition, which creates a major burden for healthcare systems. This review describes the currently used treatments for PAH and provides insight into novel therapeutic targets that aim to reduce vascular remodeling, which ultimately leads to right ventricular failure.

Seronegative spondyloarthropathies (SpA) are a group of chronic diseases, characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of diseases such as rheumatologic diseases including SpA. This prospective case-control study was designed to compare the thiol-disulfide levels as a marker of oxidative stress in SpA patients with healthy controls.

A total of 144 patients who were diagnosed as undifferentiated spondyloarthropathy (UspA, n=97), ankylosing spondylitis (AS, n=47), and 80 healthy controls were included. Serum native thiol (NT), total thiol (TT), disulfide (D) levels were measured with the fully automated Erel?s method. NT/TT, D/TT, and D/NT ratios were calculated. Thiol-disulfide levels were compared between SpA groups and healthy controls.

NT and NT/TT ratios were found to be significantly lower in the SpA group. (p<0.001). Disulfide, D/NT, and D/TT ratios were found to be significantly higher in the SpA group (p <0.001 for eachtive process better than the classical DMARD in SpA patients.

Even though interleukin-1 receptor antagonist, IL-1Ra, is used in certain inflammatory diseases, its effect on ischemia-reperfusion injury is a current research topic. We aimed to investigate the protective effects of anakinra, an IL-1Ra, on the I/R induced intestinal injury.

The rat model of intestinal ischemia-reperfusion was induced. Rats were randomized into four groups (group 1) control group, (group 2) I/R group, (group 3 and 4) treatment groups (50mg/kg and 100mg/kg, respectively). Gene expressions of Caspase-3, TNF-?, IL-1?, IL-6, and apoptotic cells in tissue samples were evaluated by PCR and TUNEL methods, respectively. Plasma levels of SOD, CAT, and MDA were studied by the ELISA method and tissue samples were examined histopathologically as well.

Anakinra inhibited the expression of IL-1?, IL-6, and TNF-? and decreased the SOD, CAT, and MDA caused by ischemia-reperfusion injury in both treatment groups. Caspase-3 expression and TUNEL-positive cell number in treatment groups as well were less. Histopathologically, anakinra better preserved the villous structure of the small intestine at a dose of 100 mg/kg than 50 mg/kg.

Anakinra decreased the intestinal damage caused by ischemia-reperfusion and a dose of 100mg/kg was found to be histopathologically more effective.

Anakinra decreased the intestinal damage caused by ischemia-reperfusion and a dose of 100mg/kg was found to be histopathologically more effective.

Frailty is associated with an increased risk of negative short-term and long-term hospital outcomes. This study aimed to evaluate the role of frailty in predicting readmission, length of stay, and quality of life in the hospitalized older adults.

This observational study was conducted at Ziaiyan Hospital, Tehran, Iran. 304 participants (65-85 years), were enrolled through the inclusion criteria from August to December 2019. The Frailty Index (FI) was assessed by the Minimum Data Set-Home Care. Readmission was obtained through telephone interviews. The length of stay was gathered by the patient?s hospital records, and the EuroQol questionnaire was used for assessing the quality of life. Data were collected by a researcher nurse at the admission time, 30, 60, and 90 days after discharge. The logistic regression model and repeated measures ANOVA were employed to analyze the association between frailty and outcomes.

According to FI, 102 (33.55%) participants were pre-frail, whereas 35 (11.51%) were frail. Iarly diagnosis in hospital settings could be beneficial for designing optimal care plans for the frail and pre-frail patients.

Headache is one of the most common neurological symptoms. It adversely affects daily life, reduces the workforce, and has high health costs. Managing this symptom in primary care will free up secondary and tertiary health services to better treat patients who need follow-up by specialists. In the present study, we aim to show the rate at which this problem can be solved in primary care for patients who applied tertiary care services with a headache for the first time.

Our research is a cross-sectional study of 207 patients who applied to the neurology clinics for the first time with headache. Two questionnaires were prepared by the researchers. IBM SPSS 21 was used for statistical analysis, and the level of significance was p<0.05.

The opinions of the patients on the evaluability of headache in primary care were compared. Family physicians and neurologists gave similar responses about the disease management, at a rate of 96.6%, this was found to be statistically significant and shows strong agreement. PI3K inhibitor drugs Both groups of physicians thought that 70% of patients, on average, who applied to the neurology clinics with headache could be managed in primary care. However, only 9.2% of the patients share this opinion with physicians. Primary headache cases constitute most of the cases that are thought to be solved in primary care. It was revealed that the number of patients seeking primary care with this complaint was lower than expected.

Patients with headache applied tertiary care instead of primary care for different reasons. Both neurologists and family physicians stated that most patients evaluated in tertiary care could be managed in primary care.

Patients with headache applied tertiary care instead of primary care for different reasons. Both neurologists and family physicians stated that most patients evaluated in tertiary care could be managed in primary care.