Mangine, GT, Eggerth, A, Gough, J, Stratton, MT, Feito, Y, and VanDusseldorp, TA. Endocrine and body composition changes across a competitive season in collegiate speed-power track and field athletes. J Strength Cond Res XX(X) 000-000, 2021-Maintaining lean mass is important for track and field (TF) athletes who compete in speed-power events, but little is known about how lean mass and related hormones might change over an 8- to 10-month collegiate season. Therefore, to monitor changes in free testosterone (T), cortisol (C), and body composition in TF athletes across their entire competitive season, 9 female (20.3 ± 1.2 years, 169 ± 5 cm, and 67.6 ± 8.5 kg) and 7 male (21.1 ± 2.0 years, 181 ± 9 cm, and 77.3 ± 5.9 kg) Division I TF athletes provided resting and fasted blood samples at the onset of their indoor season (baseline), before and on returning from the indoor conference championships (ICCs), at the beginning and end of a heavy midseason training week (HVY), and before leaving for the National Colleg the onset of HVY in men only, linear mixed models with repeated measures did not reveal any changes in hormone concentrations. Compared with baseline, an overall increase in fat-free mass was observed at HVY (∼2.74%, p = 0.023) before it reduced by 3.81% before the NCAA Championships (p = 0.022). Despite variations in training and competition, resting concentrations of hormones indicative of anabolic status remained relatively consistent over the course of an entire season in speed-power TF athletes. Coaches and athletes may consider monitoring these variables to assess the athlete’s response to the changing demands of a competitive season.

Angle closure disease was present in 59.3% of eyes with long anterior zonules. The cause is multifactorial including a thick anteriorly positioned crystalline lens, shorter axial length and increased lens thickness to axial length factor.

To study the profile of eyes with long anterior zonules (LAZ) presenting in a glaucoma clinic in a tertiary eye care centre and understand the pathogenesis of angle closure disease in these eyes.

Retrospective cross sectional study.All patients with LAZ seen from January 2014-December 2018 were included. Demographic and clinical characteristics were noted. LAZ eyes (177 eyes of 177 patients) were compared with an equal number of age and gender matched controls. LAZ was defined as radially oriented zonular fibres (both pigmented and non pigmented), extending central to the normal zonular termination zone on the anterior lens surface more than 1▒mm beyond their usual insertion of 1.42±0.24▒mm from the lens equator onto the mid peripheral zone or central to it, as seen on25 P<0.0001).

Angle closure was present in more than half the eyes with LAZ. Majority of these eyes were primary angle closure suspects or had primary angle closure. LAZ eyes had a thicker lens, shallow AC, a shorter axial length and an increased LAF as compared to age and gender matched normal controls. The presence of LAZ may be an indicator of increased risk for angle closure.

Angle closure was present in more than half the eyes with LAZ. Majority of these eyes were primary angle closure suspects or had primary angle closure. LAZ eyes had a thicker lens, shallow AC, a shorter axial length and an increased LAF as compared to age and gender matched normal controls. The presence of LAZ may be an indicator of increased risk for angle closure.Preclinical and clinical studies have sought to better understand the effect of anesthetic agents, both volatile and intravenous, and perioperative adjuvant medications on immune function. Sapogenins Glycosides clinical trial The immune system has evolved to incorporate both innate and adaptive components, which are delicately interwoven and essential for host defense from pathogens and malignancy. This review summarizes the complex and nuanced relationship that exists between each anesthetic agent or perioperative adjuvant medication studied and innate and adaptive immune function with resultant clinical implications. The most commonly used anesthetic agents were chosen for review including volatile agents (sevoflurane, isoflurane, desflurane, and halothane), intravenous agents (propofol, ketamine, etomidate, and dexmedetomidine), and perioperative adjuvant medications (benzodiazepines, opioids, nonsteroidal anti-inflammatory drugs [NSAIDs], and local anesthetic agents). Patients who undergo surgery experience varying combinations of the aforementioned anesthetic agents and adjuncts, depending on the type of surgery and their comorbidities. Each has unique effects on immunity, which may be more or less ideal depending on the clinical situation. Further study is needed to better understand the clinical effects of these relationships so that patient-specific strategies can be developed to improve surgical outcomes.Efficient pain management is essential for postoperative rehabilitation in patients undergoing a tumor resection with an immediate reconstructive surgery. Ultrasound-guided quadratus lumborum block has been described for abdominal or hip surgery, but not for concomitant surgery in the abdomen and the thigh. The paraspinous transmuscular approach has easy landmarks to perform this block. We present a case of a patient undergoing a resection of a sarcoma in the lower limb with an immediate reconstruction with a pedicled vertical designed deep inferior epigastric perforator flap, in whom a successful paraspinous transmuscular quadratus lumborum block for postoperative analgesia was performed.Pain following amputation is often poorly controlled despite the use of nerve blocks. We describe a novel pain management approach in a 56-year-old woman with episodes of poorly controlled pain following below-knee amputation despite a multimodal analgesic regimen with continuous sciatic nerve block. Effective analgesia was observed during those episodes when the nerve block catheter was briefly stimulated at low frequency using a nerve stimulator designed for regional anesthesia procedural guidance. This case report explains the utilization and rationale of this hybrid technique of combined peripheral nerve stimulation and locoregional analgesia via perineural nerve block catheters to augment analgesia.