To compare short-term outcomes of Arabs versus Jewish infants in Israel.

We used the Israel national VLBW infant database to compare adjusted mortality and major morbidities rates of Arabs versus Jewish infants delivered between January 1995 and December 2016. Multivariable logistic regression analyses were performed to study the association of ethnicity with the odds for mortality and neonatal morbidities.

The study population comprised 22431 VLBW, very preterm (<32 weeks gestation) infants (27.7% Arabs and 72.3% Jewish) without congenital malformations. The Arab infants had significantly higher odds ratios for mortality, and most neonatal morbidities. Despite the significant decline in mortality over time in both ethnic groups, the difference in mortality rates remained unchanged over time.

We found significant ethic disparity that remained unchanged over time. Some of the disparities identified in this study may be amenable to improvement through proper policies and education.

We found significant ethic disparity that remained unchanged over time. Some of the disparities identified in this study may be amenable to improvement through proper policies and education.

Determine odds ratios for neonatal abstinence syndrome (NAS) and neonatal intensive care unit (NICU) admissions for babies born to women associated with severe mental illness (SMI) and gestational opioid use.

A retrospective pharmacoepidemiologic study using Medicaid data included 17,130 mothers with and 170,430 mothers without SMI, and their babies. Odds ratios for NAS and NICU admissions among babies born to mothers associated with SMI diagnoses and associated with varying degrees of gestational opioid use were determined using logistic regression.

The adjusted odds ratio for a baby in the methadone or buprenorphine group having NAS was 168.93 [95% confidence interval (CI) 148.78-191.71, P < 0.001] and was 9.64 (95% CI 8.74-10.65, P < 0.001) for NICU admissions compared to babies with no opioid exposure.

Chronicity of prescription maternal opioid use was the strongest factor associated with NAS and NICU admissions.

Chronicity of prescription maternal opioid use was the strongest factor associated with NAS and NICU admissions.

To examine the extents to which low tidal volume (VT) and endotracheal tube (ETT) leakeage influence the accuracy of ETCO

for estimating arterial PCO

(PaCO

) in very low birth weight (VLBW) infants with mechanical ventilation.

An observational study. We evaluated a total of 287 paired ETCO

and PaCO

values as well as VTs obtained from 22 VLBW infants with ventilation. Deming regression, quadratic discriminant analysis, and Bland-Altman analysis were performed.

ETCO

and PaCO

were correlated (r

 = 0.5897, p < 0.0001). A quadratic discrimination analysis of the VT and the percentage of leak yielded 70.4% [95%CI, 65.1 to 75.7] discrimination for the agreement between ETCO

and PaCO

. ETCO

was strongly correlated with PaCO

in the discriminant function Z > 0 group (r

 = 0.7234, p < 0.0001).

Our results indicate that ETCO

is a good surrogate for PaCO

when VT is high and ETT leak is low.

Our results indicate that ETCO2 is a good surrogate for PaCO2 when VT is high and ETT leak is low.Allogeneic HSCT represents the only potentially curative treatment for very high risk (VHR) ALL. Two consecutive international prospective studies, ALL-SCT-(I)BFM 2003 and 2007 were conducted in 1150 pediatric patients. 569 presented with VHR disease leading to any kind of HSCT. All patients >2 year old were transplanted after TBI-based MAC. The median follow-up was 5 years. 463 patients were transplanted from matched donor (MD) and 106 from mismatched donor (MMD). 214 were in CR1. Stem cell source was unmanipulated BM for 330 patients, unmanipulated PBSC for 135, ex vivo T-cell depleted PBSC for 62 and cord-blood for 26. There were more advanced disease, more ex vivo T-cell depletion, and more chemotherapy based conditioning regimen for patients transplanted from MMD as compared to those transplanted from MSD or MD. Median follow up (reversed Kaplan Meier estimator) was 4.99 years, median follow up of survivals was 4.88, range (0.01-11.72) years. The 4-year CI of extensive cGvHD was 13 ± 2% and 17 ± 4% (p = NS) for the patients transplanted from MD and MMD, respectively. 4-year EFS was statistically better for patients transplanted from MD (60 ± 2% vs. 42 ± 5%, p  less then  0.001) for the whole cohort. PFI-6 in vivo This difference does not exist if considering separately patients treated in the most recent study. There was no difference in 4-year CI of relapse. The 4-year NRM was lower for patients transplanted from MD (9 ± 1% vs. 23 ± 4%, p  less then  0.001). In multivariate analysis, donor-type appears as a negative risk-factor for OS, EFS, and NRM. This paper demonstrates the impact of donor type on overall results of allogeneic stem cell transplantation for very-high risk pediatric acute lymphoblastic leukemia with worse results when using MMD stem cell source.The radioactive nature of radon makes it a powerful tracer for fluid movements in the crust, and a potentially effective marker to study processes connected with earthquakes preparatory phase. To explore the feasibility of using soil radon variations as earthquakes precursor, we analyse the radon concentration data recorded by two stations located close to the epicentre of the strongest mainshock (Mw 6.5 on October 30, 2016) of the seismic sequence which affected central Italy from August 2016. The two stations CTTR and NRCA operate in the framework of the permanent Italian Radon monitoring Network and recorded almost continuously since 2012 and 2016, respectively, the latter being installed just after the first mainshock of the sequence (Mw 6.0 on August 24, 2016). An increase of radon emanation is clearly visible about 2 weeks before the Mw 6.5 event on both the time series, more pronounced on NRCA, nearer to the epicentre, suggesting the possibility of a direct association with the earthquake occurrence. An independently developed detection algorithm aimed at highlighting the connections between radon emission variations and major earthquakes occurrence succeeds in forecasting the Mw 6.