In conclusion, this study provides evidence of the risk of food contamination by VerA and shed light on its toxicological effect on human colon cells. Chlorine addition in swimming pools ensures the microbiological quality of the water and the bathers’ safety. However, water chlorination is associated with disinfection byproducts (DBP) formation and adverse health effects. The impact of operating parameters and innovative water treatment systems on DBPs levels has been reported in several studies, but sampling campaign in real pools remain difficult to carry out, mainly due to unexpected attendance variations. This study presents the development of a pilot pool plant allowing to perform experiments under controlled and reproducible conditions. Bathers inputs were simulated both for the organic load and for the mechanical agitation of water. Two sampling campaigns were performed during the building of the pilot, before and after the hall was closed. Key operating parameters such as chlorine dose, water temperature and attendance were controlled and monitored. DBP levels in the pilot plant were representative of French indoor swimming pools and the impact of bathers’ activity was visible on volatile DBPs. Furthermore, correlations could be stated between operating parameters and DBP levels. Stripping effectively reduced volatile DBP concentrations in water. Moreover, energy consumption data, which are usually very scarce in experimental studies, showed the influence of heat pump consumption on the global energy consumption. Organic contaminants (polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and chlorinated paraffins (CPs)) and heavy metals and metalloids (Ag, Cd, Co, Cr, Cu, Hg, Ni, Pb, Sb, Zn) were analysed in surface soil samples from the Agbogbloshie e-waste processing and dumping site in Accra (Ghana). In order to identify which of the pollutants are likely to be linked specifically to handling of e-waste, samples were also collected from the Kingtom general waste site in Freetown (Sierra Leone). The results were compared using principal component analyses (PCA). PBDE congeners found in technical octa-BDE mixtures, highly chlorinated PCBs and several heavy metals (Cu, Pb, Ni, Cd, Ag and Hg) showed elevated concentrations in the soils that are likely due to contamination by e-waste. PCAs associated those compounds with pyrogenic PAHs, suggesting that burning of e-waste, a common practice to isolate valuable metals, may cause this contamination. Moreover, other contamination pathways, especially incorporation of waste fragments into the soil, also appeared to play an important role in determining concentrations of some of the pollutants in the soil. Concentrations of several of these compounds were extremely high (especially PBDEs, heavy metals and SCCPs) and in some cases exceeded action guideline levels for soil. This indicates that exposure to these contaminants via the soil alone is potentially harmful to the recyclers and their families living on waste sites. Many organic contaminants and other exposure pathways such as inhalation are not yet included in such guidelines but may also be significant, given that deposition from the air following waste burning was identified as a major pollutant source. BACKGROUND Dynamic postural control during everyday tasks is poorly understood in people following anterior cruciate ligament reconstruction (ACLR). Understanding dynamic postural control can provide insight into potentially modifiable impairments in people following ACLR who are at increased risk for second ACL injury and/or knee osteoarthritis. RESEARCH QUESTION Determine whether measures indicative of dynamic postural control differ between individuals with and without ACLR during stair ascent and descent. METHODS Seventeen individuals with ACLR (>1 yr post-surgery) and 16 age and sex-matched healthy controls participated. Centre of pressure (COP) measures included i) COP excursion, ii) COP velocity, and iii) dynamic time-toboundary (TTB). Mixed linear models were used to compare COP measures for the ACLR leg, non-ACLR leg, and healthy controls during stair ascent and stair descent. RESULTS There were no statistically significant differences observed during stair ascent (all p > 0.05). Several statistical differences were found during stair descent for individual with ACLR, but not between those with ACLR and healthy controls. The ACLR leg had higher medial-lateral COP excursion (mean difference 1.06 cm, [95 %CI 0.08-2.06 cm], p = 0.036; effect size = 0.38) compared to the non-ACLR leg during stair descent. BML-WN110 In addition, the ACLR leg had a lower medial-lateral TTB (mean difference -13 ms [95 %CI -38 to 2 ms], p = 0.005; effect size = 0.49) and medial-lateral TTB normalized to stance time (mean difference -5.8 % [95 %CI -10.3 to 1.3 %], p = 0.012; effect size = 0.80) compared to the non-ACLR leg during stair descent. No statistical differences were observed for anterior-posterior measures during stair descent (all p > 0.05). SIGNIFICANCE Taken together, findings indicate that there are small to large differences in medial-lateral postural control in the ACLR leg compared to the non-ACLR leg during stair descent. Further work is required to understand clinical implication of these novel observations. During spinal cord (SC) regeneration in the tail of Rana dalmatina tadpoles few neurons are regenerated from the ependymal epithelium. Using microscopic methods, immunofluorescence, tract tracing and electron microscopy, the present study has analyzed the cells generated in the caudal SC during the first 20 days of regeneration under normal and stress conditions. Since early larval stages, the regenerating SC contains few nerve cells (2-3%) and more numerous immune cells (5-7%), namely heterophil granulocytes, macrophages and lymphocytes. Few regenerated nerve cells are connected to the normal SC by axons detected after application of the retrograde fluorescent tracer Dil. Cell degeneration in the regenerating SC is commonly observed, including also loss of nerve cells, a process that occurs well in advance from metamorphosis. Furthermore, under lightly stress conditions, when tadpoles are kept in agitated water during tail regeneration, nerve degeneration and the number of immune cells significantly increases in the regenerating SC, a mean of 13.