Resistance nature of Plasmodium falciparum (P. falciparum) to the most effective antimalarial drug, Artemisinin, intimidate the global goal of total eradication of malarial. In an attempt to overcome this challenge, the research was aimed at designing derivatives of β-amino alcohol grafted 1,4,5-trisubstituted 1,2,3-triazoles with improve activity against the P. falciparum through structural modifications of the most active compound (design template), and their activity determined using the developed theoretical predictive model. To achieve this, the geometries were optimized via density functional theory (DFT) using B3LYP/6-31G∗ basis set to generate molecular descriptors for model development. Analysis of the developed model and the descriptors mean effect lead to the design of derivatives with improved activity. Five (5) theoretical models were developed, where the model pIC50 = 5.95067(SpMin5_Bhi) – 0.0323461(RDF45m) + 0.0203865 (RDF95e) + 0.0499285 (L1m) – 3.50822 with the highest coefficient of determh higher activities revealed compound 21C to have an antimalarial activity of pIC50 = 6.7573 higher than it co-designed compounds and even the standard drug. This claim could be verified through molecular docking to determine their interaction with the target protein.Helminths born diseases are related to pitiable management practices and improper control strategies. The medicinal plants contain various phytoconstituents that are liable for their anthelmintic activity. The aerial parts of the Chenopodium album were successively extracted with microwaves assisted extraction using petroleum ether, ethyl acetate, methanol, hydroalcoholic and aqueous solvents to get respective extracts (CAPE, CAEE, CAME, CAHE, and CAAE). All the extracts were analyzed for preliminary phytochemical screening for the identification of phytoconstituents. The anthelmintic activity was analyzed on Indian adult earthworms Eisenia foetida using piperazine citrate (PCT) as a standard drug. All the extracts (apart from CAAE) lead to paralysis and fatality of the earthworms. CAEE extract exhibits highly significant anthelmintic activity at a 10 mg/ml concentration by causing paralysis and fatality of earthworms and was more potent than PCT suspension. At a concentration of 10 mg/ml, paralysis and death time for CAEE was recorded as (10.08 ± 1.11) and (65.28 ± 2.09) respectively, while for standard piperazine citrate, it was recorded as (22.96 ± 1.12) and (65.09 ± 1.23). The CAEE exhibits two major compounds by LC-MS, i.e., NG and DG, that are mainly accountable for the Chenopodium album anthelmintic activity. The plant possesses GABA-mimetic action and thereby leads to flaccid, reversible paralysis of the body wall muscle.Wrinkled fibrous nanosilica (WFNS) which functionalized by ionic liquid modified Fe3O4 NPs and CuI salts has been synthesized and characterized with FE-SEM, TEM, FT-IR, FAAS, EDX, and, XRD, VSM, and BET-BJH analysis. This new and effective magnetic ceramic nanocatalyst has been applied towards rapid synthesis of N-sulfonylamidines using reaction of phenyl acetylene, substituted sulfonyl azide and various amines under solvent-free conditions in very short reaction time. Higher catalytic activity CuI/Fe3O4NPs@IL-DFNS in the reaction is because of special structure of DFNS and existence of ionic liquids on its pores which act as a robust anchors to the loaded various nano-particles. So, this lead to no leaching of them from the pore of the composite. Shorter reaction time, higher yield, recovery of the catalyst using an external magnet and its reusability for 8 series without noteworthy reduction in its activity are the advantages of newly synthetic catalyst toward efficient synthesis of N-sulfonylamidines.Salmonella is contracted through the consumption of untreated water and contaminated food. The contraction and spread of water-related Salmonella in resource-poor communities can be reduced by using solar disinfection (SODIS) to treat the water before its consumption. SODIS is a water sanitizing technique that relies on natural sunshine. It is a cost-effective, inexpensive, environmentally, and user-friendly means of treating microbiologically contaminated water. This water disinfection method has saved many lives in communities vulnerable to water-related infections worldwide. At present, the success of SODIS has mainly been attributed to permanent inactivation of water pathogens ability to grow. However, little to no information exists as to whether immune responses to the solar inactivated pathogens are induced in SODIS water consumers. This study assessed the potential for solar inactivated S. Typhimurium to induce an immune response in mice. Results show that solar inactivated S. Typhimurium can induce bactericidal antibodies against S. Typhimurium. Furthermore, an increase in the secretion of interferon-gamma (IFN-γ) was observed in mice given the solar inactivated S. Typhimurium. These findings suggest that solar inactivated S. Typhimurium induces a humoral and cellular immune response. However, the level of protection afforded by these responses requires further investigation.The giant freshwater prawn, Macrobrachium rosenbergii, is an economically valuable species that are distributed throughout the Asia-Pacific region. With the natural population declining due to overfishing, aquaculture of this species is deemed necessary. Hence, it is essential to understand the mechanisms regulating reproduction in order to increase their production. Prostaglandins (PGs) play an important role in reproduction in most vertebrates and several invertebrates. It has been proposed that crustaceans have PGs but the prostanoids pathway in the giant freshwater prawn is still unclear. In this study, we identified 25 prostanoid-related genes involved in the biosynthesis of active prostanoids in M. rosenbergii using in silico searches of transcriptome data. Linrodostat mouse Comparative analysis of encoded proteins for the MroPGES2 gene with other species was performed to confirm their evolutionary conservation. Gene expression analysis revealed the correlation of MroPGES2 gene expression level with the progress of ovarian development.