0% and 8.8%, respectively, for weight <P

. For boys older than CA 1 m and for girls older than CA 3 m, the proportion of weight-for-length >P

assessed by the WHO growth standards was greater than that assessed by the China growth charts.

Compared with the China growth charts, the WHO growth standards can further reduce the number of diagnoses of abnormal physical growth, are more helpful in avoiding overnutrition interventions, and are more sensitive in the early detection of delayed head circumference growth.

Compared with the China growth charts, the WHO growth standards can further reduce the number of diagnoses of abnormal physical growth, are more helpful in avoiding overnutrition interventions, and are more sensitive in the early detection of delayed head circumference growth.

To assess the benefits and safety of early human fibrinogen concentrate in postpartum haemorrhage (PPH) management.

Multicentre, double-blind, randomised placebo-controlled trial.

30 French hospitals.

Patients with persistent PPH after vaginal delivery requiring a switch from oxytocin to prostaglandins.

Within 30minutes after introduction of prostaglandins, patients received either 3g fibrinogen concentrate or placebo.

Failure as composite primary efficacy endpoint at least 4g/dl of haemoglobin decrease and/or transfusion of at least two units of packed red blood cells within 48hours following investigational medicinal product administration. Secondary endpoints PPH evolution, need for haemostatic procedures and maternal morbidity-mortality within 6±2weeks after delivery.

437 patients were included 224 received FC and 213 placebo. At inclusion, blood loss (877±346ml) and plasma fibrinogen (4.1±0.9g/l) were similar in both groups (mean±SD). Failure rates were 40.0% and 42.4% in the fibrinogen and placebo groups, respectively (odds ratio [OR]=0.99) after adjustment for centre and baseline plasma fibrinogen; (95%CI 0.66-1.47; P=0.96). No significant differences in secondary efficacy outcomes were observed. The mean plasma FG was unchanged in the Fibrinogen group and decreased by 0.56g/l in the placebo group. No thromboembolic or other relevant adverse effects were reported in the Fibrinogen group versus two in the placebo group.

As previous placebo-controlled studies findings, early and systematic administration of 3g fibrinogen concentrate did not reduce blood loss, transfusion needs or postpartum anaemia, but did prevent plasma fibrinogen decrease without any subsequent thromboembolic events.

Early systematic blind 3g fibrinogen infusion in PPH did not reduce anaemia or transfusion rate, reduced hypofibrinogenaemia and was safe.

Early systematic blind 3 g fibrinogen infusion in PPH did not reduce anaemia or transfusion rate, reduced hypofibrinogenaemia and was safe.

Inhalation of welding fume may cause pulmonary disease known as welder’s lung. At our centre we came across a number of welders with systemic iron overload and prolonged occupational history and we aimed at characterizing this novel clinical form of iron overload.

After exclusion of other known causes of iron overload, 20 welders were fully evaluated for working history, hepatic, metabolic and iron status. MRI iron assessment was performed in 19 patients and liver biopsy in 12. Pyrotinib We included 40 HFE-HH patients and 24 healthy controls for comparison.

75% of patients showed lung HRCT alterations; 90% had s-FERR>1000ng/mL and 60% had TSAT>45%. Liver iron overload was mild in 8 and moderate-severe in 12. The median iron removed was 7.8g. Welders showed significantly lower TSAT and higher SIS and SIS/TIS ratio than HFE-HH patients. Serum hepcidin was significantly higher in welders than in HFE-HH patients and healthy controls. At liver biopsy, 50% showed liver fibrosis that was mild in four, and moderate-severe in two. Liver staging correlated with liver iron overload.

Welders with prolonged fume exposure can develop severe liver iron overload. The mechanism of liver iron accumulation is quite different to that of HFE-HH suggesting that reticuloendothelial cells may be the initial site of deposition. We recommend routine measurement of serum iron indices in welders to provide adequate diagnosis and therapy, and the inclusion of prolonged welding fume exposure in the list of acquired causes of hyperferritinemia and iron overload.

Welders with prolonged fume exposure can develop severe liver iron overload. The mechanism of liver iron accumulation is quite different to that of HFE-HH suggesting that reticuloendothelial cells may be the initial site of deposition. We recommend routine measurement of serum iron indices in welders to provide adequate diagnosis and therapy, and the inclusion of prolonged welding fume exposure in the list of acquired causes of hyperferritinemia and iron overload.

Physiologic reserve is an important prognostic indicator. Due to its complexity, no single test can measure an individual’s physiologic reserve. Frailty is the phenotypic expression of decreased reserve and portends poor prognosis. Both subjective and objective tools have been used to measure one or more components of physiologic reserve. Most of these tools appear to predict pre-transplant mortality, but only some predict post-transplant survival.

Incorporation of these measures of physiologic reserve in the clinical and research settings including prediction models will be reviewed and the applicability to patient related outcomes discussed.

Commonly used tools, in patients with cirrhosis, that have been associated with clinical outcomes were reviewed.

The strength of subjective tools lies in low cost, wide availability and quick assessments at bedside. A disadvantage of these tools is the manipulative capacity, restricting their value in allocation processes. The strength of objective tests lies in objective measurements and the ability to measure change. The disadvantages include complexity, increased cost, and limited accessibility.

Heterogeneity in definitions and tools used has prevented further advancement or a clear role in transplant assessment. Consistent use of objective tools including six-minute walk test, gait speed, liver frailty index or short physical performance battery are recommended in clinical and research settings.

Heterogeneity in definitions and tools used has prevented further advancement or a clear role in transplant assessment. Consistent use of objective tools including six-minute walk test, gait speed, liver frailty index or short physical performance battery are recommended in clinical and research settings.