Secondary outcomes include the impact on other parent-reported safety behaviours, medically-attended injuries, self-efficacy for home safety and knowledge of child development and injury risk using questionnaires and emergency department attendance data; implementation (reach, acceptability, barriers, facilitators) of home safety promotion assessed through interviews and observations; and cost-effectiveness using medically-attended injury costs ascertained from healthcare records.

If shown to be effective and cost-effective this study will provide a practical resource to underpin national guidance. The study could inform public health prevention strategies to reduce home injury in children most at risk, while delivering cost savings to health and care services.

ISRCTN31210493; Pre result.

ISRCTN31210493; Pre result.Between March and May 2020, Japan experienced a lockdown due to the COVID-19 crisis. Empty roads possibly triggered speed-related traffic violations that caused fatal motor vehicle collisions (MVCs). Using police data on the monthly number of fatal MVCs between January 2010 and February 2020 in which motor vehicle drivers were at fault, we forecasted the numbers of fatal MVCs due to the speed-related violations during the lockdown and compared these with those observed. We also compared the observed to forecasted using the ratio of the number of speed-related fatal MVCs to that of non-speed related fatal MVCs. The observed numbers of speed-related fatal MVCs were within the 95% CIs of the forecasted numbers. The observed ratio was higher than the forecasted ratio in April (p=0.016). In the second month of the lockdown, drivers were more likely to commit speed-related violations that caused fatal MVCs than before the lockdown.Aarskog-Scott syndrome (AAS), also known as faciogenital dysplasia (FGD, OMIM # 305400), is an X-linked recessive inheritance, characterized by short stature, facial dysmorphism, and skeletal abnormalities. We report the clinical and molecular analysis of a family with ASS. A 31-month-old boy and his cousin were initially mistaken for having Noonan syndrome owing to short stature and facial dysmorphism. Considering the family history, we suspected the possibility of an X-linked genetic disease and performed targeted gene panel sequencing; a novel hemizygous variant c.1192-1 G>A in FGD1 was identified in both the proband and his cousin. This is the first report of ASS in Korea. Targeted gene panel sequencing can be an effective tool for diagnosing rare complex syndromes, including ASS.Paired box (PAX) 2, encoded on chromosome 10 in humans, plays a key role in kidney development. The first 3 exons of the gene are highly conserved among species. PAX2 mutations in autosomal dominant papillorenal syndrome (OMIM #120330) are associated with congenital anomalies of the kidney, urinary tract, and eye. A 37-year-old male was admitted to our transplant center for kidney transplantation due to end-stage renal disease (ESRD) caused by chronic glomerulonephritis. Interestingly, 5 members of his family also suffered from ESRD requiring hemodialysis in adulthood. Other ocular or brain anomalies were not reported in this pedigree. We extracted genomic DNA from buccal swabs or peripheral blood samples from the proband and his family members. We identified a novel heterozygous c.130C>G (p.Leu44Val) missense PAX2 mutation in this family by exome sequencing analysis, which we confirmed by Sanger sequencing in the affected family members. This mutation is located in the N-terminus of the paired box domain of PAX2 and predicted to be a pathogenic mutation by in-silico analysis. We report a novel PAX2 mutation identified by exome sequencing in a family with adult ESRD in the absence of other congenital syndromic features.

The study objective was to determine whether there is an association between changes in tuberculosis (TB) patient serum albumin levels during anti-TB treatment and subsequent treatment outcomes.

We conducted a retrospective study to reveal associations between dynamic changes in TB patient serum albumin levels and stratified clinical outcomes.

For TB patients with good treatment outcomes, serum albumin concentrations at treatment initiation and during treatment at 1 month (35.7±5.0 g/L), at 2 months (38.1±4.4 g/L) and at treatment completion (43.2±4.9 g/L) were significantly greater than baseline level (30.9±3.7 g/L, P<0.01). Conversely, for patients with poor treatment outcomes, serum albumin concentrations showed no significant treatment-associated change relative to the baseline level (P>0.05).

Our data demonstrates that serum albumin level changes during early anti-TB treatment are useful indicators for identifying TB patients at high-risk for treatment failure.

Our data demonstrates that serum albumin level changes during early anti-TB treatment are useful indicators for identifying TB patients at high-risk for treatment failure.

This study aimed to establish a new external quality assessment (EQA) of chromosomal karyotype analysis.

Chimeric assembly A1 was established by collecting chimeric chromosome images prepared artificially from chromosomally abnormal amniocytes remaining after prenatal diagnosis. Chimeric assembly B1 and nonchimeric assembly C1 were constructed through the collection of chimeric and nonchimeric chromosome images from prenatal diagnosis, respectively. Then, chromosome images were selected randomly from assemblies A1, B1, or C1 to send to 20 technicians via email to verify the validity of a new EQA of chromosomal karyotype analysis.

According to the EQA of 20 technicians, 47,XX,+mar from assembly A was easily misdiagnosed as 47,XX,+19 or 47,XXY, and 45,XX,t(13;22) (q10;q10) was misdiagnosed as 45,XX,13S

,-22. The total misdiagnosis rate was 3.8%. For assembly B, 46,X,+mar and 46,X,idic(Y) were easily misdiagnosed as 46,XY and 46,X,+mar, respectively. In addition, some testers missed 47,XXX in 47,XXX[2]/46,XX[48], as well as 47,XX,+18 in 46,XX [47]/47,XX,+18[3], and 45,X and 47,XXX in 46,XX[47]/45,X[2]/47,XXX[1]. selleckchem The total misdiagnosis rate was 4.2%. All karyo-types from assembly C were correctly diagnosed, although incorrect descriptions used for 4% of cases.

The quality of chromosome karyotype analysis can be comprehensively evaluated by a new EQA based on assembly A1 or B1.

The quality of chromosome karyotype analysis can be comprehensively evaluated by a new EQA based on assembly A1 or B1.