Though the F-GFA and G-GFA showcased higher water absorption ratio than the natural sand due to the presence of unreacted fly ash and GGBS particles, the complete replacement of fine aggregate with geopolymerized sand initiated the adequate compressive strength attainment up to 90% of natural sand, by reacting with the lime expelled out of the hydration process of cement in the mortar specimens developed in this experimental study. selleck products The geopolymer itself is hydrophilic in nature, and it will also aid for the higher water absorption ratio of the polymer sand. The microstructure of the samples was further examined through optical microscope, scanning electron microscope, and X-ray diffraction analysis in order to corroborate the experimental results of this study. The results thus obtained strongly recommend the potential of the F-GFA and G-GFA as an ideal replacement material for natural sand.Harmful cyanobacterial blooms (HCB) have severe impacts on marine and freshwater systems worldwide. They cause oxygen depletion and produce potent cyanotoxins that have detrimental effects on human and environmental health and deteriorate the water quality. Biological treatment of the water for control of cyanobacterial blooms and removal of cyanotoxins can be a more economical and environment-friendly way, as they do not result in production of undesirable by-products. Most biological treatments of cyanobacteria and cyanotoxins have concentrated largely on bacteria, with little attention paid to algicidal fungi. Therefore, this review aims to provide an overview of the current status and the main progresses achieved in fungal biodegradation of HCB and cyanotoxin research. The available data revealed that 15 fungal species had high lytic activity against cyanobacteria, and 6 species were capable of degrading microcystins (MCs). Some fungal species (e.g., Aurobasidium pullulans and Trichoderma citrinoviride) have been identified to selectively inhibit the growth of cyanobacteria rather than beneficial species of other algal groups. Interestingly, some fungal strains (Trichaptum abietinum, Trichoderma citrinoviride) exhibited di-functional trait, being efficient in lysing cyanobacteria and degrading MCs released from the cells after decay. Beyond a comprehensive review of algicidal and toxin-degrading activities of fungi, this paper also identifies and prioritizes research gaps in algicidal fungi. The review also gives insights to the potential applications of algicidal fungi for removal of cyanobacterial blooms and their cyanotoxins from the aquatic environment.Glioblastoma is one of the deadliest forms of primary adult tumors, with median survival of 14.6 months post-diagnosis despite aggressive standard of care treatment. This grim prognosis for glioblastoma patients has changed little in the past two decades, necessitating novel treatment modalities. One potential treatment modality is cancer immunotherapy, which has shown remarkable progress in slowing disease progression or even potentially curing certain solid tumors. However, the transport barriers posed by the blood-brain barrier and the immune privileged status of the central nervous system pose drug delivery obstacles that are unique to brain tumors. In this review, we provide an overview of the various physiological, immunological, and drug delivery barriers that must be overcome for effective glioblastoma treatment. We discuss chemical modification strategies to enable nanomedicines to bypass the blood-brain barrier and reach intracranial tumors. Finally, we highlight recent advances in biomaterial-based strategies for cancer immunotherapy that can be adapted to glioblastoma treatment.Behçet’s disease (BD) is a systemic autoinflammatory vasculitis. It occurs predominantly in Turkey but very rarely in Europe. The clinical manifestations of BD involve the skin and mucosal membranes; cardiovascular, gastrointestinal and nervous systems; and the eyes and joints. A 26-year-old man was repeatedly hospitalized at the Department of Dermatology of the Medical University of Bialystok. He had a family history of family members’ deaths from unknown cause and a long personal history of recurring headaches and nonspecific pain in the chest as well as a 2-year history of recurring painful erosions on the oral mucosa. Recently, before admission to hospital, another erosion had appeared on the scrotum, which rapidly evolved into a painful ulceration. The patient also presented a large erosion in the area of the right hip and acne lesions. He consulted doctors of different specialties and underwent laboratory and imaging tests. Considering the symptoms, BD was diagnosed. Azathioprine was introduced, along with topical treatment. Great improvement of the skin lesions was achieved. He was later admitted to the department a few times for follow-up visits and remains in good general condition. BD is an extremely rare disease in Europe, especially in Poland. The fact that BD is a rare disease outside Asia leads to lower awareness and the possibility of not considering it in the differential diagnosis. The great diversity of symptoms also causes difficulties in tracking this disease. The various manifestations of BD require a broad spectrum of additional tests and an interdisciplinary approach to the patient.In vivo flow cytometry (IVFC) was first designed to detect circulating cells in a mouse ear. It allows real-time monitoring of cells in peripheral blood with no need to draw blood. The IVFC field has made great progress during the last decade with the development of fluorescence, photoacoustic, and multiphoton microscopy. Moreover, the application of IVFC is no longer restricted to circulating cells. IVFC based on fluorescence and photoacoustic are most widely applied in biomedical research. Methods based on fluorescence are often used for object monitoring in superficial vessels, while methods based on photoacoustics have an advantage of label-free monitoring in deep vessels. In this chapter, we introduce technical points and key applications of IVFC. We focus on the principles, labeling strategies, sensitivity, and biomedical applications of the technology. In addition, we summarize this chapter and discuss important research directions of IVFC in the future.