Ischemic stroke is a multifactorial disease contributing to mortality and neurological dysfunction. Isoliquiritin (ISL) has been reported to possess a series of pharmacological activities including antioxidant, anti-inflammatory, antifungal, anti-depression, anti-neurotoxicity and pro-angiogenesis activities but whether it can be used for ischemic stroke treatment remains unknown.

The goal of this study is to explore its therapeutic effect on ischemic stroke and demonstrated the potential mechanism of ISL in zebrafish model.

Using the photothrombotic-induced adult zebrafish model of ischemic stroke, we visualized the telencephalon (Tel) and optic tectum (OT) infarction injury at 24h post-light exposure for 30min by TTC and H&E staining. The effect of ISL on neurological deficits was analyzed during open tank swimming by video tracking. The antioxidant activity against ischemia injury was quantified by SOD, GSH-Px and MDA assay. Transcriptome analysis of zebrafish Tel revealed how ISL regulating geneeffect on Tel injury, neurological deficits and oxidative damages. ISL could regulate a variety of genes related to immune, apoptosis and necrosis pathways against complex cascade reaction after ischemia. These findings enriched the study of ISL, making it a novel multi-target agent for ischemic stroke treatment.

Tel was highly sensitive to the brain ischemia injury in zebrafish model of ischemic stroke. ISL significantly exerted protective effect on Tel injury, neurological deficits and oxidative damages. ISL could regulate a variety of genes related to immune, apoptosis and necrosis pathways against complex cascade reaction after ischemia. These findings enriched the study of ISL, making it a novel multi-target agent for ischemic stroke treatment.

We aimed to investigate characteristics and outcomes of patients receiving mechanical thrombectomy (MT) between minor to moderate stroke and severe stroke caused by acute basilar artery occlusion (BAO).

We retrospectively reviewed the data of all patients with BAO who underwent MT from three stroke centers between January 2016 and January 2020. The patients were dichotomized as minor to moderate or severe stroke group according to their admission National Institutes of Health Stroke Scale (NIHSS) score <21and ≥21. Patient characteristics, imaging findings, and outcomes were compared between the two groups.

A total of 72 patients were included in this study. The posterior circulation Alberta Stroke Program Early CT Score (PC-ASPECTS) in the minor to moderate stroke patients were significantly higher than that of patients with severe stroke (P = 0.013). The good posterior circulation collateral scores (PC-CS) (6-10) were more commonly found in patients with minor to moderate stroke than in patients with severe stroke (58.14 % vs 10.34 %,P < 0.001). There were similar rates of successful recanalization between the two groups. Patients with minor to moderate stroke had a higher rate of favorable outcomes (mRS score 0-2, 60.47 % vs 20.69 %, P = 0.002) and a lower rate of periprocedural complications (4.65 % vs 31.03 %, P = 0.005) and mortality (4.65 % vs 24.14 %, P = 0.026) at 3 months after MT compared with the patients with severe stroke.

Acute BAO patients with minor to moderate stroke had better posterior circulation collateral and had better outcomes after MT than those patients with severe stroke.

Acute BAO patients with minor to moderate stroke had better posterior circulation collateral and had better outcomes after MT than those patients with severe stroke.Pyrolysis has shown great potential for sewage sludge valorisation and management by producing value-added chemicals. Although the product process yields are extensively studied, a few studies exist without consensus on the kinetic properties of sewage sludge pyrolysis. As a result, a study to investigate the thermal decomposition characteristics of Gauteng sewage sludge (GSS) at various heating rates (10, 20, and 30 °C/min), its pyrolysis kinetic parameters, reaction mechanism and thermodynamic properties was meticulously conducted. The results show that sewage sludge decomposition occurs in three stages, whereby the main decomposition (active pyrolysis) takes place at 150-570 °C. Fourier transform infrared spectroscopy (FTIR) analysis results confirm progression of thermal decomposition of GSS and drive off volatile compounds and formation of aromatic structures during TGA studies of GSS. CQ31 An increase in heating rate shifts the characteristic temperatures towards higher temperatures with the highest decomposition rate of 1.10%/min.mg at 30 °C/min. The activation energies of GSS pyrolysis were calculated using Flynn-Wall-Ozawa, Kissinger-Akahira-Sunose and Starink methods and averaged as 225.92, 218.04 and 218.97 kJ/mol, respectively. GSS pyrolysis involves complex reaction chemistry with high reactivity whereby reactions that follow third order and three-dimensional diffusion-reaction mechanisms dominated the process. However, these mechanisms cannot be used explicitly to define the global pyrolysis kinetics due to the occurrence of multiple simultaneous reactions. The obtained thermodynamic and kinetic data will advance and amplify the design, simulation and optimisation of global energy pyrolysis units for production of value-added chemicals.The development of efficient strategies for the removal of heavy metal ions from aqueous solutions is rapidly demanded as these contaminants are very toxic and carcinogenic and show detrimental effects on the living creatures. The main focus of the current study is on the preparation and assessment of electrospun adsorptive nanofiber membranes for the removal of toxic Ni(II) and Cu(II) from wastewater in the ultrafiltration process. Hydrothermally synthesized titanate nanotubes (TNT) was modified with thiol functional groups and then directly incorporated to the polyvinyl chloride nanofiber matrices via electrospinning process to fabricate an adsorptive membrane. The as-prepared electrospun nanofiber membranes and the nanoadsorbents were characterized with respect to the physiochemical properties, surface structure and morphology, applying XPS, FTIR, FESEM, EDX and TEM analysis and then, the membranes were evaluated in terms of the removal of the heavy metal ions in a continuous ultrafiltration mode. In adsorptive filtration of the metal ions, the effective factors including nanoadsorbents loading (0.