Biomass obtained from microalgae research studies gained momentum in recent years because of their extensive application potential in multiple industries such as high-value nutraceuticals, bioproducts, cosmetics, animal feed industries, and biofuels while being a sustainable and environmentally friendly option. Although they have high biomass yields and rapid growth rates there are some limitations and challenges that remain for large-scale commercialized cultivation and harvesting methods of microalgae. Since there are multiple pathways related to efficient cultivation and harvesting methods to be viable, this study adopted, TOPSIS (Technique for Order Preference by Similarity to Ideal Solution), a multicriteria decision-making tool, to find the most acceptable alternative by using excel spreadsheets to evaluate the information that is derived from literature and pilot-scale studies. As a result, tubular (helical) and plate (flat panel) photobioreactors (PBRs) for cultivation and chemical harvesting (with chitosan) and bio-flocculation for harvesting were deemed suitable, while plastic bag PBR and suspended air flotation were deemed unsuitable.Carbamate compounds are commonly applied in agricultural sectors as alternative options to the recalcitrant organochlorine pesticides due to their easier breakdown and less persistent nature. However, the large-scale use of carbamates also leads to toxic environmental residues, causing severe toxicity in various living systems. The toxic effects of carbamates are due to their inhibitor activity against the acetylchlolinesterase enzyme. This enzyme is crucial for neurotransmission signaling in living beings. Hence, from the environmental point of view, the elimination of carbamates is a worldwide concern and priority. selleckchem Microbial technology can be deliberated as a potential tool that can work efficiently and as an ecofriendly option for the dissipation of carbamate insecticides from contaminated environments by improving biodegradation processes via metabolic activities of microorganisms. A variety of bacterial and fungal species have been isolated and characterized and are capable of degrading a broad range of carbamates in soil and water environments. In addition, microbial carbamate hydrolase genes (mcd, cehA, cahA, cfdJ, and mcbA) were strongly implicated in the evolution of new metabolic functions and carbamate hydrolase enzymes. However, the accurate localization and appropriate functions of carbamate hydrolase enzymes/genes are very limited. To explore the information on the degradation routes of carbamates and promote the application of biodegradation, a study of molecular techniques is required to unlock insights regarding the degradation specific genes and enzymes. Hence, this review discusses the deep understanding of carbamate degradation mechanisms with microbial strains, metabolic pathways, molecular mechanisms, and their genetic basis in degradation.

Multiple studies over the past 4 decades have shown the significant benefit of breast cancer screening (BCS) in reducing mortality rates from breast cancer (BC). However, significant debate exists about the role of BCS in this regard, with some studies also showing no benefit in terms of mortality along with issues such as overdiagnosis, health care utilisation costs, psychological distress or overtreatment. To date, no BCS study has focused on disability. Hence the aim of this study is to evaluate the relative contribution of BCS approaches to age-standardized mortality and disability-adjusted life years (DALYs) rates along with other related risk factors, from a country-level perspective.

This study created a country-dataset by merging information from the Global Burden of Disease study regarding female age-standardized BC mortality, DALYs rates and other risk factors with the BCS programme availability at the national or regional level (versus no or only pilot such programme), BCS type (mammography, dif BCS on DALYs too. Additional factors, such as diabetes, high levels of LDL-c or smoking seemed to be related to BC mortality and disability, and could be considered as additional components of possible interventions to be used alongside BCS to optimize the BCS benefit on patients.

These data further support the positive effects of BCS in relation to age-standardized BC mortality rates, and for the first time show the impact of BCS on DALYs too. Additional factors, such as diabetes, high levels of LDL-c or smoking seemed to be related to BC mortality and disability, and could be considered as additional components of possible interventions to be used alongside BCS to optimize the BCS benefit on patients.

Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder which could impair someone’s quality of life and is also associated with poor outcomes from many diseases. Currently, the evidence regarding the link between OSA and coronavirus disease 2019 (COVID-19) is still conflicting. This study aims to analyze the relationship between OSA and poor outcomes of COVID-19.

We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until December 10th, 2020. All articles published on COVID-19 and OSA were retrieved. The quality of the study was assessed using the Newcastle-Ottawa Scale (NOS) tool for observational studies. Statistical analysis was done using Review Manager 5.4 software.

A total of 21 studies with 54,276 COVID-19 patients were included in this meta-analysis. This meta-analysis showed that OSA was associated with composite poor outcome [OR 1.72 (95% CI 1.55-1.91), p<0.00001, I

=36%, random-effect modeling] and its subgroup which comprised of severe COVID-19 [OR 1.70 (95% CI 1.18-2.45), p=0.005], ICU admissions [OR 1.76 (95% CI 1.51-2.05), p<0.00001], the need for mechanical ventilation [OR 1.67 (95% CI 1.48-1.88), p<0.00001], and mortality [OR 1.74 (95% CI 1.39-2.19), p<0.00001].

Extra care and close monitoring should be provided to patients with OSA to minimize the risk of infections. Simple questionnaires such as STOP-Bang questionnaire can be used for screening patients who may be at risk for severe adverse outcomes.

Extra care and close monitoring should be provided to patients with OSA to minimize the risk of infections. Simple questionnaires such as STOP-Bang questionnaire can be used for screening patients who may be at risk for severe adverse outcomes.