32 weeks of PPROM manifestation (27.03-fold). In amniotic membranes a similar trend of reduction of FoxP3 expression was found, overall level decreased in 2.33 times, especially in 31-32 weeks of PPROM manifestation (10.64-fold). CONCLUSION Conclusions Among Zaporizhzhia population, combination of IL4 (rs2243250), IL10 (rs1800896 and rs1800872), RLN2 (rs4742076 and rs3758239) supports the role for functional polymorphisms in immunoregulatory genes in the susceptibility to PTL, associated with PPROM. Marked increased transcriptional activity of components of innate (TLR2, TLR4), adaptive (Th1, Th17) immune system and conversely decreased expression of Treg (FoxP3) in the maternal-fetal interface are involved in immune pathways of PTB and contribute in the fetal inflammatory response syndrome.OBJECTIVE The aim Assessment of the level of knowledge of nurses of sepsis depending of type of hospital word and years of working experience. PATIENTS AND METHODS Materials and methods The audit was carried out in the group of 100 randomly selected nurses working in three different hospital wards Hospital Emergency Ward, Intensive Care Unit and Surgery Unit. Study dedicated authors survey was developed as audits research tool. The study was conducted in May 2019. RESULTS Results The general knowledge of nurses of sepsis is quite good. Most of the respondents answered correctly to questions about definition of sepsis and septic shock, causes of sepsis and relevant laboratory parameters. Unfortunately, more detailed questions, about diagnostic criteria or chances of complete cure, caused more difficulties. Some responders lack up-to-date knowledge about sepsis and septic shock. CONCLUSION Conclusion More emphasis should be placed on the availability of up-to-date information on sepsis and verification of the knowledge of nurses working in hospital are should be taken to raise awareness and stress importance of up-to-date knowledge in order to provide the highest quality and utmost effectiveness of patient care. Nurses working in the Hospital Emergency Ward and Intensive Care Unit have more knowledge about the subject of our study than the staff in the Surgery Unit.OBJECTIVE The aim to study the association between rs1899663-polymorphic variant of HOTAIR gene and clear cell renal cell carcinoma (CCRCC) development in Ukrainian population. PATIENTS AND METHODS Materials and methods whole venous blood from 101 Ukrainians with CCRCC (42 females and 59 males) and 100 control subjects (34 females and 66 males) were enrolled in the study. DNA extraction was performed using GeneJET Whole Blood Genomic DNA Purification Mini Kit (Thermo Fisher Scientific, USA). Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP) was used for HOTAIR rs1899663 genotyping. The Statistical Package for Social Science software (SPSS, version 17.0, Chicago, IL, USA) was used for all calculations. RESULTS Results It was found the lack of association between HOTAIR rs1899663 single nucleotide polymorphism and CCRCC emergence as well as tumor metastasis property in dominant, recessive, over-dominant and additive crude models of inheritance, as well after the adjustment for age, sex, smoking and excessive alcohol consumption (P > 0.05). CONCLUSION Conclusions No association was found between HOTAIR rs1899663-polymorphic variant and CCRCC development in Ukrainian population. Further studies with extended samples are required to validate these results.OBJECTIVE The aim The study of skin microbial landscape and immune-endocrine parameters as well as improvement of treatment efficiency in patients with different clinical course of psoriasis by using narrowband UVB phototherapy. PATIENTS AND METHODS Materials and methods We examined 89 patients with psoriasis (51 men and 38 women) aged 18-60. click here The comparison group consisted of 43 psoriasis patients comparable by age, sex and clinical course with those from the main group (46 patients). Cytokine levels IL-4, IL-8, IL-10, TNFα, thyroid peroxidase (TPO) and thyroglobulin (Tg) autoantibodies and microbial flora of skin were determined in patients with psoriasis. RESULTS Results The study finds that conventional therapy does not have sufficient corrective impact on immune-endocrine disorders and the use of narrow-band light therapy has shown that it has a focused corrective impact on cytokine production and modulating effect on the level of TPO and Tg autoantibodies and the state of skin automicroflora of lesions in patients suffering from psoriasis. CONCLUSION Conclusions Using UVB (311 nm) therapy in patients with psoriasis allows improving efficiency of treatment and limiting clinical signs in the form of achieving remission and significant improvement in patients’ health without any negative dynamic changes.INTRODUCTION Newborn jaundice is caused by increased levels of bilirubin in the blood of the newborn during the first days after birth. Generally, neonatal jaundice does not need to be treated, however, if the blood bilirubin concentration becomes too high, it can cause neurological damage. Due to the prevalence of neonatal jaundice, it is important to assess its risk factors and their importance. This study at the National University Hospital of Iceland from 1997-2018, determines the risk factors for severe neonatal jaundice and their significance. MATERIAL AND METHODS This was a retrospective case control study conducted at the National University Hospital of Iceland. It included all newborns diagnosed with severe jaundice (≥350 micromol/L) following a pregnancy of at least 37 weeks that were treated at the National University Hospital of Iceland from 1997 until 2018. General information on the pregnancy, health of the child at birth, as well as the diagnosis and treatment of jaundice was collected. 339 chiin the evaluation of jaundice in post-natal home care. Monitoring of neonates with Rhesus incompatibility in Iceland exemplary. Boys are at an increased risk for severe neonatal jaundice. It is espe-cially noteworthy given that the negative effect of jaundice on learning ability appears to be greater in boys than in girls.