8, respectively.

There is moderate agreement between CVIs obtained from centered and decentered directional single OCT scans of the same subfoveal area. Studies investigating choroidal vascularity should be standardized by using the same OCT beam direction in all scans.

There is moderate agreement between CVIs obtained from centered and decentered directional single OCT scans of the same subfoveal area. Studies investigating choroidal vascularity should be standardized by using the same OCT beam direction in all scans.

To report surgical observations formulated during the first 120 cases of subretinal gene therapy in patients with inherited retinal degenerations (IRDs).

A two-surgeon team compiled surgical observations and formulated surgical pearls based on the consecutive cases of subretinal viral vector injection in patients enrolled in clinical trials focusing on choroideremia, achromatopsia, and RPGR-associated retinitis pigmentosa, as well as patients with RPE65-associated Leber congenital amaurosis receiving FDA-approved voretigene neparvovec-rzyl therapy.

120 subretinal surgeries were performed by a two-surgeon team. Key anatomical features pertinent to surgical management were noted and are described in this manuscript. Surgical decision making for successful subretinal administration of viral vectors and management of potential surgical challenges were formulated.

Lessons learned during subretinal gene therapy cases may be helpful to other surgeons entering clinical trials or performing post-approval gene therapy administration. Surgical pearls outlined in this manuscript may also be helpful for other targeted subretinal therapies such as cellular transplantation or retinal prosthesis implantation.

Lessons learned during subretinal gene therapy cases may be helpful to other surgeons entering clinical trials or performing post-approval gene therapy administration. Surgical pearls outlined in this manuscript may also be helpful for other targeted subretinal therapies such as cellular transplantation or retinal prosthesis implantation.

To clarify whether internal limiting membrane (ILM) peeling provides better outcomes for patients with idiopathic epiretinal membrane (ERM).

Randomized controlled trials (RCTs) comparing ERM removal with and without ILM peeling were searched in Embase, PubMed, Web of Science, Cochrane Library and CNKI before 15 April 2020. The pooled mean difference (MD) for best corrected visual acuity (BCVA), central macular thickness (CMT), and odds ratio (OR) for recurrence were calculated.

8 RCTs involving 422 eyes were included. No significant difference in BCVA (final follow-up MD 0.03 logarithm of the minimum angle of resolution [1.5 Early Treatment Diabetic Retinopathy Study letters]; 95% CI -0.04 to 0.09 [-4.5 to 2 Early Treatment Diabetic Retinopathy Study letters]; P=0.40) or recurrence rate (OR, 0.21; 95% CI 0.04 to 1.05; P=0.06) between the groups was observed. However, patients with ILM peeling presented thicker CMT at 3 months (MD, 16.36; 95% CI 1.26 to 31.46; P=0.03), 6 months (MD, 22.64; 95% CI 10.29 to 34.98; P=0.0003) and the final follow-up (MD, 25.87; 95% CI 13.96 to 37.79; P<0.0001).

ILM peeling did not significantly improve the postoperative visual outcome or decrease recurrence, but result in thicker CMT, indicating inessential for idiopathic ERM.

ILM peeling did not significantly improve the postoperative visual outcome or decrease recurrence, but result in thicker CMT, indicating inessential for idiopathic ERM.

To compare refractive outcomes and accuracy of modern optical biometry (OB), swept-source optical coherence tomography (OCT), ultrasound biometry (UB) and effect of macula status in rhegmatogenous retinal detachment (RRD) managed with either combined phacovitrectomy or sequential vitrectomy and cataract surgery compared to a control, phacoemulsification alone.

Retrospective, comparative, consecutive study of 154 eyes; Group 1 underwent phacovitrectomy (n70), group 2 underwent vitrectomy with subsequent cataract surgery (n41) and group 3 underwent cataract surgery alone (n43).

No difference in mean absolute error (MAE) was found between Group 2 (0.41±0.56) and Group 3 (0.41±0.29); both were superior to Group 1 (0.74±0.57). Between Group 1 and Group 2, no statistically significant difference in MAE was found between macula-on subgroups (p=0.057) but this was statistically significant between macula-off subgroups (p=0.009). Subgroup analysis by biometry showed that the difference in MAE between macula-off OB Group 1 and Group 2 against our control, Group 3, were not significant (p=0.078 and p=0.119 respectively); MAE was significantly different when considering macula-off UB cases (p<0.001 and p=0.038 respectively).

All three groups had comparable refractive outcomes when using OB. However, phacovitrectomy macula-off cases had inferior refractive outcomes when the UB had to be used. In macula-off RRD, when OB is not reliable, it is preferable to perform sequential surgery rather than phacovitrectomy.

All three groups had comparable refractive outcomes when using OB. However, phacovitrectomy macula-off cases had inferior refractive outcomes when the UB had to be used. Pentetic Acid In macula-off RRD, when OB is not reliable, it is preferable to perform sequential surgery rather than phacovitrectomy.

The aim of this study was to determine the natural course of vitreomacular traction (VMT) in patients with diabetic retinopathy (DR), and to evaluate the factors associated with VMT relief.

Seventy-four eyes of 65 patients with VMT accompanying DR were evaluated retrospectively. The presence of intravitreal injection (IVI), and the presence of panretinal photocoagulation (PRP) were obtained from the medical records of the patients. Spontaneous release of VMT (R-VMT), the horizontal length of vitreomacular traction (HLVMT), the presence of hyperreflective retinal spots (HRS), the presence of epiretinal membrane (ERM), and grade of VMT were evaluated from the spectral-domain optical coherence tomography (SD-OCT) images. Factors associated with the spontaneous release of VMT were evaluated by logistic regression analysis.

Spontaneous release was observed in 28 eyes (37.8%). The HLVMT was lower in the R-VMT group compared with the persistent VMT (P-VMT) group (p=0.03). P-VMT group had a higher rate of HRS and ERM compared with the R-VMT group (respectively; p=0.