88, and accuracy 0.86) and prosody-related features for females (sensitivity 0.73, specificity 0.86, and accuracy 0.77). The correlation distance between negative and positive MIS was significantly shorter in the depressed group than in the healthy control (F=18.574, P < 0.001).

Small sample size and relatively homogenous clinical profile of depression could limit the generalizability.

While reading MIS, spectral and energy-related acoustic features for males and prosody-related features for females are good discriminators for major depressive disorder. These features may be used as biomarkers of depression in the elderly.

While reading MIS, spectral and energy-related acoustic features for males and prosody-related features for females are good discriminators for major depressive disorder. These features may be used as biomarkers of depression in the elderly.

COVID-19 pandemic has major ramifications for global health and economy, with growing concerns about economic recession and implications for mental health. Here we investigated the associations between pandemic-related income loss with financial strain and mental health trajectories over a 1-month course, in two independent cohorts.

Two independent studies were conducted in the U.S and in Israel at the beginning of the outbreak (March-April 2020, T1; study I N=2904, study II N=1267) and at a 1-month follow-up (T2; study I N=1318, study II N=241). Mixed-effects models were applied to assess associations among COVID-19-related income loss, financial strain, and pandemic-related worries about health, with anxiety and depression, controlling for multiple covariates including pre-COVID-19 income.

In both studies, income loss and financial strain were associated with greater depressive symptoms at T1, above and beyond T1 anxiety, worries about health, and pre-COVID-19 income. Worsening of income loss was associated with exacerbation of depression at T2 in both studies. Worsening of subjective financial strain was associated with exacerbation of depression at T2 in one study (US).

Income loss and financial strain were uniquely associated with depressive symptoms and their exacerbation over time, above and beyond pandemic-related anxiety. In times when a myriad of stressors are affecting mental health worldwide, our findings reveal specific links between the economic impact of COVID-19 and psychiatric outcomes.

Income loss and financial strain were uniquely associated with depressive symptoms and their exacerbation over time, above and beyond pandemic-related anxiety. In times when a myriad of stressors are affecting mental health worldwide, our findings reveal specific links between the economic impact of COVID-19 and psychiatric outcomes.Microanalysis is a method for recording and coding interactional behavior. It has been often compared to a social microscope, for its power in detailing the second-by-second dynamics of social interaction. Microanalysis has deep multidisciplinary foundations, that privilege the description of interactions as they naturally occur, with the purpose of understanding the relations between multiple and simultaneous streams of behaviors. In developmental science, microanalysis has uncovered structural and temporal elements in mother-infant interactions, improving our understanding of the effects of mother-infant interpersonal adaptation in the infant’s cognitive and social-emotional development. PD98059 chemical structure Detailed manual coding is time intensive and resource demanding, imposing restrictions to sample size, and the ability to analyze multiple behavioral modalities. Moreover, recent increases in the density of multivariate data require different tools. We review present-day techniques that tackle those challenges (1) sensing techniques for motion tracking and physiological recording; (2) exploratory techniques for detecting patterns from high-density data; and (3) inferential and modeling techniques for understanding contingencies between interactional time series. Two illustrations, from recent developmental research, reveal the power of bringing new lenses to our social microscope (1) egocentric vision, the use of head mounted cameras and eye-trackers in capturing the infant’s first-person perspective of a social exchange; and (2) daily activity sensing, wearable multimodal sensing that brought mother-infant interaction research to the environments where it naturally unfolds.We have evaluated the contribution of nitric oxide (NO) in static magnetic field (SMF-200 mT for 1h) induced tolerance towards UV-B stress in soybean seedlings using various NO modulators like sodium nitroprusside (SNP), inhibitor of nitrate reductase (NR) sodium tungstate (ST), NO synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) and diphenylene iodonium (DPI) a NADPH oxidase inhibitor. The UV-B exposure significantly reduced germination, seedling growth together with activities of total amylase, NOS and NR in seedlings from un-primed seeds whereas SMF-primed seedlings showed significant enhancement in all these parameters along with higher level of NO/ROS. The supply of NO donor, SNP further improved all the seedlings parameters in un-primed and SMF-primed seeds after UV-B exposure. While ST, L-NAME and DPI significantly reduced the SMF-induced seedling performance after UV-B exposure. The gene expression study also showed significant up-regulation of α-amylase (GmAMY1, GmAMY2), nitric oxide synthase (GmNOS2) and nitrate reductase (GmNR2) encoding genes in UV-B exposed SMF-primed seedlings over un-primed seedlings. In particular, SNP+UV-B treatment enhanced the GmNOS2 expression in both unprimed (31.9-fold) and SMF-primed (93.2-fold) seedlings in comparison to their respective controls of CK+UV-B. In contrast, L-NAME+UV-B treatment reduced the SMF-induced GmNOS2 expression (4.8-fold) and NOS activity (76%). It confirmed that NO may be the key signaling molecule in SMF stimulated tolerance towards UV-B stress during early seedling growth and NOS may possibly be accountable for SMF-triggered NO production in soybean seedlings exposed to UV-B irradiations.

Individuals with Down syndrome (DS) show a delayed acquisition of gross motor skills. Among gross motor skills, hopping is a particular form of jumping that can be performed using one leg. Despite its large use during play and physical activity, this skill in adults with DS has not received much attention so far. Here, we aim at investigating hopping skill in adults with DS both from a quantitative and qualitative point of view.

Center of mass and dominant leg kinematics during hopping over distance were recorded from 24 adult individuals with DS and from 21 typically developed adults (TD) using two inertial measurement units positioned on the posterior aspect of the lower back and on the lateral malleolus of the hopping leg. From linear acceleration and angular velocity signals, hopping frequency (HF), cycle, stance and flight duration (CD, SD, FD), vertical stiffness (K

) and peak to peak linear acceleration and angular velocities about the cranio-caudal, antero-posterior and medio-lateral axes were extracted.