These findings suggested that the crosslinked CMKGM/CS nanogels might be a promising delivery system for nutrients.The effect of high amylose corn starch (HAS)-fatty acid complexes on the gel properties, protein secondary structure, microstructure, fatty acid content, and sensory properties of surimi under high-temperature treatment were investigated. The formation of HAS-fatty acid complexes increased melting temperature and decreased average particle size of HAS. The addition of HAS-fatty acid complexes significantly improved the breaking force, deformation and whiteness of surimi gels. The water in surimi gels containing HAS or HAS-fatty acid complexes became increasingly immobilized. HAS or HAS-fatty acid complexes promoted protein conformational transition from α-helix structure to other three secondary structure. Surimi gels added with HAS-fatty acid complexes had more compact network structure and higher fatty acid content. Moreover, the better sensory properties were obtained in surimi gels containing HAS-fatty acid complexes. Therefore, starch-fatty acid complexes not only could improve the gel properties of surimi, but also enhance its fatty acid content.Introducing Bos indicus (BI) genetics into a beef herd has the potential to increase environmental sustainability. When introducing BI genetics, there are concerns regarding negative impacts on temperament, growth, and carcass characteristics. Implants are routinely used in the United States, with majority of cattle on feed receiving an anabolic implant to improve growth and efficiency, however research regarding the interaction between cattle breed type and anabolic implants is limited. This research compared the use of implants in BI influenced animals versus Bos taurus in a feedlot setting. Twenty steers were stratified by initial weight in a 2 × 2 factorial design examining two different breeds Angus (AN; n = 10) or Santa Gertrudis influenced (SG; n = 10), and two implant strategies no implant (CON; n = 10) or a combined implant containing 120 mg TBA and 24 mg E2 (IMP; n = 10; Revalor-S, Merck Animal Health). We hypothesized that anabolic implants would improve growth and feedlot performance of BI influenG genetics, while implanting steers improved economic return by $46 a head. This research provides evidence suggesting that BI influenced animals may respond differently to anabolic implants when compared to BT animals. Economic analyses demonstrate that anabolic implants improve economic return to beef producers, while introducing SG genetics decreases economic return in animals raised in more temperate climates.Rollover risk on mountainous interstates is a major concern for transportation agencies due to the combined mixed effects of adverse weather conditions and complex topography. Such crashes incur hazardous consequences on road users’ lives. Therefore, a correlated random parameters logit modeling framework was employed to investigate the influences of crash precursors on rollover risk to identify effective safety countermeasures. This approach was selected to account for both the crash contributing factors’ unobserved heterogeneity effects and the correlations among those effects. The data, used in this study, were those of single-truck crashes on Wyoming’s interstate curved sections. The traditional logit and uncorrelated random parameters, or mixed, logit models were attempted as well. With that, the analysis results indicated that the fit of the correlated random parameters logit model was superior to those of the others. It also revealed insights regarding correlations among random parameters that were obscure in the other models. According to its results, on average, veering off the road, overcorrections and severe winds raised the risk of single-truck rollover crashes. On the other hand, median barriers, roadside guardrails, tight horizontal curves, icy road surfaces, wet surfaces and surfaces covered by loose material, in general, reduced the likelihood of rollovers. Correlations, such as those between severe winds and icy surfaces and those between roadside guardrails and icy surfaces, were inferred as well. This study’s results will assist transportation officials in efficiently identifying appropriate countermeasures to mitigate the impact of truck rollovers particularly during adverse weather conditions.Histone deacetylase inhibitors have often been used in combination treatment of various types of cancers due to their non-genotoxic epigenetic potential. Valproic acid (VPA) is a well-known histone deacetylase inhibitor. Conjugate of VPA with a phtoactive platinum diimine complex through an ester bond has been fabricated to potentiate the photocytotoxicity of the photosensitizer. Its capability to generate singlet oxygen, behavior in the presence of esterase, and photocytotoxicity in tumor cells have also been studied. The results revealed that the novel VPA-modified platinum diimine complex could produce singlet oxygen efficiently and release VPA in the presence of porcine liver esterase. The results also suggested that incorporation of VPA moiety into the platinum diimine complex might significantly enhance the cytotoxicity of the complex.Alzheimer’s disease is a fatal neurological disorder affecting millions of people worldwide with an increasing patient population as average life expectancy increases. Accumulation of amyloid beta (Aβ) plaques is characteristic of the disease and has been the target of numerous failed clinical trials. In light of this, therapeutics that target mechanisms of neuronal death beyond Aβ aggregation are needed. One potential target is the formation of reactive oxygen species (ROS) that are created during an interaction between Aβ and copper ions. AZ-33 inhibitor This work shows that ROS production can be slowed by disrupting the interaction between Aβ and copper using copper chelating compounds. We demonstrated that ROS are produced in the presence of Aβ and copper in solution by monitoring H2O2 production using a fluorescence-based assay, which increased when Cu2+ interacted with Aβ. In addition, we were able to show reduced ROS production, without exacerbating the aggregation of Aβ and in some cases alleviating it, by adding copper chelating ligands to the solution.