Introduction Obtaining the best possible medication history is the crucial step in medication reconciliation. Our aim was to evaluate the potential contributions of the main data sources available – patient/caregiver, hospital medical records, and shared electronic health records – to obtain an accurate ‘best possible medication history’. Material and methods An observational cross-sectional study was conducted. Adult patients taking at least one medicine were included. Patient interview was performed upon admission and this information was reconciled with hospital medical records and shared electronic health records, assessed retrospectively. Concordance between sources was assessed. In the shared electronic health records, information was collected for four time-periods the preceding three, six, nine and 12-months. The proportion of omitted data between time-periods was analysed. Results A total of 148 patients were admitted, with a mean age of 54.6 ± 16.3 years. A total of 1639 medicines were retrieved. Only 29% were collected simultaneously in the three sources of information, 40% were only obtained in shared electronic health records and only 5% were obtained exclusively from patients. The total number of medicines gathered in shared electronic health records considering the different time frames were 778 (three-months), 1397 (six-months), 1748 (nine-months), and 1933 (12-months). Discussion The use of shared electronic health records provides data that were omitted in the other data sources available and retrieving the information at six months is the most efficient procedure to establish the basis of the best possible medication history. Conclusion Shared electronic health records should be the preferred source of information to supplement the patient or caregiver interview in order to increase the accuracy of best possible medication history of the patient, particularly if collected within the prior six months.Introduction The participation in extracurricular activities reduces the attributed importance to some causes of perfectionism, which influences the prevalence of burnout in medical students. This study aimed to investigate how this relationship occurs and which factors it is dependent on, in order to create strategies directed at these potential targets. Material and methods We developed a questionnaire that assesses the participation in extracurricular activities, including a survey regarding the reasons for perfectionism and part of the Copenhagen Burnout Inventory adapted for students. The questionnaire’s application to medical students of the Masters Degree in Medicine of the Faculty of Medicine, University of Coimbra was followed by statistical analysis. Results In a sample of 360 students, 40% ranked highly in personal burnout, and 28.1% in study-related burnout, while 22.2% showed high levels of burnout in both components. Students who participated in extracurricular activities were less frequently associated with simultaneous personal-related and study-related high levels of burnout (p = 0.013). The kind of chosen extracurricular activity was not associated with the prevalence of burnout. Discussion Only 53.9% of students participate in extracurricular activities. Such participation is associated with a lower prevalence of burnout if it is practiced several times per week. The choice of one kind of activity over another does not seem to influence the prevalence of this syndrome, all of which are associated with benefits in different domains. Conclusion We observed a lower prevalence of burnout among students that engaged in extracurricular activities. Further studiesthat can infer causality in this relationship are needed, in order to establish effective solutions specific to the medical course context.Old age is associated with a loss of motor functions and a general progressive decline in cognitive functions. Physical exercise is one of the ways in which inflammatory levels in general can be reduced, and therefore physical exercise can be considered a biological aging decelerator. In this article we examine the relationships between physical exercise and inflammatory markers reported for the different physical exercise protocols that have been used in studies with older individuals, as well as the effects of these regimens. The different types of exercises programmed, and methods used to implement them were very heterogeneous in the articles we analysed. selleck chemicals llc Both, the aerobic exercise and resistance training protocols produced a decrease in plasma levels of IL-6, CRP and TNF-α, and an increase of IL10 plasma levels as a chronic effect. However, the acute-response of physical exercise appeared to be an initial increase in IL-6 expression and plasma IL-6 levels. Continuing with these exercise programs usually subsequently achieved a chronic response in which there was a decrease in both the basal levels of IL-6, CRP and TNF-α, and the IL-6 produced as acute responses. Regardless of the type of exercise performed, it seems that the exercise parameters, intensity, duration, subject variables, fitness, and level of inflammation are key factors in achieving the expected balance between pro-inflammatory and antiinflammatory cytokines.Background Endocrine disruptors (EDs) disrupt the standard operation of the endocrine systems, resulting in untoward effects. EDs have gained extensive consideration due to their severe adverse impacts on public and wildlife health. A variety of compounds from both natural and synthetic origin may cause endocrine disruptions. These may be found in industrial chemicals, persistent organic pollutants, and products of regular use including pharmaceuticals, medical equipments, implants, medical/surgical and dental devices, cosmetics, food products, other consumer goods, their packaging and processing materials. Apart from direct consumption or use, these chemicals may impact by entering our food chain or ecosystem. These chemicals act by mimicking the hormones or blocking their receptors or interfering in their normal production, absorption, distribution, metabolism and excretion. The implementation of regulatory framework on complex multidisciplinary field of EDs brings enormous challenges, which pose barriers to regulatory process.