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Stefansen Moesgaard posted an update 1 day, 2 hours ago
In addition to the enhanced light emission efficiency, the novel hybrid indium bromide demonstrates significantly improved environmental stability. These findings may pave the way for the consideration of hybrid organic In(III) halides for light emission applications.The fast development of terahertz technologies demands high-performance electromagnetic interference (EMI) shielding materials to create safe electromagnetic environments. Despite tremendous breakthroughs in achieving superb shielding efficiency (SE), conventional shielding materials have high reflectivity and cannot be re-edited or recycled once formed, resulting in detrimental secondary electromagnetic pollution and poor adaptability. Herein, a hydrogel-type shielding material incorporating MXene and poly(acrylic acid) is fabricated through a biomineralization-inspired assembly route. The composite hydrogel exhibits excellent stretchability and recyclability, favorable shape adaptability and adhesiveness, and fast self-healing capability, demonstrating great application flexibility and reliability. More interestingly, the shielding performance of the hydrogel shows absorption-dominated feature due to the combination of the porous structure, moderate conductivity, and internal water-rich environment. High EMI SE of 45.3 dB and broad effective absorption bandwidth (0.2-2.0 THz) with excellent refection loss of 23.2 dB can be simultaneously achieved in an extremely thin hydrogel (0.13 mm). Furthermore, such hydrogel demonstrates sensitive deformation responses and can be used as an on-skin sensor. This work provides not only an alternative strategy for designing next-generation EMI shielding material but also a highly efficient and convenient method for fabricating MXene composite on macroscopic scales.Hypoxia is a common phenomenon among most solid tumors that significantly influences tumor response toward chemo- and radiotherapy. Understanding the distribution and extent of tumor hypoxia in patients will be very important to provide personalized therapies in the clinic. Without sufficient vessels, however, traditional contrast agents for clinical imaging techniques will have difficulty in accumulating in the hypoxic region of solid tumors, thus challenging the detection of hypoxia in vivo. To overcome this problem, herein we develop a novel hypoxia imaging probe, consisting of a hypoxia-triggered self-assembling ultrasmall iron oxide (UIO) nanoparticle and assembly-responding fluorescence dyes (NBD), to provide dual-mode imaging in vivo. In this strategy, we have employed nitroimidazole derivatives as the hypoxia-sensitive moiety to construct intermolecular cross-linking of UIO nanoparticles under hypoxia, which irreversibly form larger nanoparticle assemblies. The hypoxia-triggered performance of UIO self-assembly not only amplifies its T2-weighted MRI signal but also promotes the fluorescence intensity of NBD through its emerging hydrophobic environment incorporated into self-assemblies. In vivo results further confirm that our hypoxic imaging probe can display a prompt MRI signal for the tumor interior region, and its signal enhancement performs a long-term effective feature and gradually reaches 3.69 times amplification. Simultaneously, this probe also exhibits obvious green fluorescence in the hypoxic region of tumor sections. Accordingly, we also have developed a MRI difference value method to visualize the 3D distribution and describe the extent of the hypoxic tumor region within the whole bodies of mice. Due to its notable efficiency of penetration and accumulation inside a hypoxic tumor, our hypoxia imaging probe could also be considered as a potential candidate as a versatile platform for hypoxia-targeted drug delivery, and meanwhile its hypoxia-related therapeutic efficacy can be monitored.Cyclotides are plant-derived peptides found within five families of flowering plants (Violaceae, Rubiaceae, Fabaceae, Solanaceae, and Poaceae) that have a cyclic backbone and six conserved cysteine residues linked by disulfide bonds. Their presence within the Violaceae species seems ubiquitous, yet not all members of other families produce these macrocyclic peptides. The genus Palicourea Aubl. (Rubiaceae) contains hundreds of neotropical species of shrubs and small trees; however, only a few cyclotides have been discovered hitherto. Herein, five previously uncharacterized Möbius cyclotides within Palicourea sessilis and their pharmacological activities are described. Cyclotides were isolated from leaves and stems of this plant and identified as pase A-E, as well as the known peptide kalata S. Cyclotides were de novo sequenced by MALDI-TOF/TOF mass spectrometry, and their structures were solved by NMR spectroscopy. Because some cyclotides have been reported to modulate immune cells, pase A-D were assayed for cell proliferation of human primary activated T lymphocytes, and the results showed a dose-dependent antiproliferative function. The toxicity on other nonimmune cells was also assessed. This study reveals that pase cyclotides have potential for applications as immunosuppressants and in immune-related disorders.We describe an all-electron G0W0 implementation for periodic systems with k-point sampling implemented in a crystalline Gaussian basis. Our full-frequency G0W0 method relies on efficient Gaussian density fitting integrals and includes both analytic continuation and contour deformation schemes. Due to the compactness of Gaussian bases, no virtual state truncation is required as is seen in many plane-wave formulations. Selleck B022 Finite size corrections are included by taking the q → 0 limit of the Coulomb divergence. Using our implementation, we study quasiparticle energies and band structures across a range of systems including molecules, semiconductors, rare gas solids, and metals. We find that the G0W0 band gaps of traditional semiconductors converge rapidly with respect to the basis size, even for the conventionally challenging case of ZnO. Using correlation-consistent bases of polarized triple-ζ quality, we find the mean absolute relative error of the extrapolated G0W0@PBE band gaps to be only 5.2% when compared to experimental values.