The median overall survival (OS) in the 68 patients with BRMs was only 1.16 years (95% CI 0.78-1.61). However, OS for patients who had a solitary BRM, who had BRM but no other distant metastasis, or who underwent surgery or stereotactic radiosurgery favorable. CONCLUSION Patients with proximally located adenocarcinoma, or with lymph node metastases are at a higher risk for BRMs and patients fare better after treatment of isolated BRM.The notion of causal evidence in medicine has been the subject of wide philosophical debate in recent years. The notion of evidence has been discussed mostly in connection with Evidence Based Medicine and, more in general, with the assessment of causal nexus in medical, and especially research contexts. “Manipulative evidence” is one of the notions of causal evidence that has stimulated much debate. see more It has been defined in slightly different ways, attributed different relevance, and recently placed at the core of Gillies’ “action-related theory of causality”, a view specifically meant to address causation in medicine. While in general sympathetic to Gillies’ account, and totally convinced of the relevance of manipulative evidence and different sorts of interventions in the biomedical sciences, we believe that some further qualifications are needed to allow the notion of manipulative evidence to better express features of medical practice. In particular, we provide some qualification of the role of “interventional evidence” proposed by Gillies, suggesting a distinction between “interventional evidence” and “evidence for interventions”. A case study from research on rare diseases is analyzed in depth and a multifaceted notion of manipulative evidence put forward that allows better understanding of what manipulations in medical contexts amount to and what their targets are.Although much attention has already been paid to Kant’s ideas on race, more research is needed to determine the sources that he used to support his portrayal of non-white races. A comprehension of the intellectual context gives us the opportunity to see the way in which Kant wished to contribute to discussions on inheritable human characteristics and the inferiority of certain races. This article will emphasize the relevance of the views of Joseph Priestley and Alexander Wilson for Kant’s hypothesis on the relation between phlogiston and the black race. This allows us to comprehend the methodology that Kant prescribed for natural history and its consequences for his understanding of the inferiority of the black race.In this study molecularly imprinted polymers (MIP) based on carbon quantum dots (CQDs) and polymer dots (PDs) are developed for selective determination of acetamiprid using fluorometry. The measurement is based on the fluorescence quenching of CQDs and PDs in the presence of acetamiprid. PDs were prepared using a one-step aqueous synthesis method from ascorbic acid and diethylenetriamine at room temperature. CQDs were prepared from the same materials using the hydrothermal method at 180 °C. These particles were characterized using field emission scanning electron microscopy (FE-SEM), FTIR, dynamic light scattering (DLS), X-ray diffraction (XRD), UV-Vis, and fluorescence. The quantum yield was 47% for PDs and 8% for CQDs. Then, molecularly imprinted polymers (MIP) were prepared based on PDs and CQDs using reverse microemulsion method. The fluorescence quenching of CQD@MIPs and PD@MIPs was investigated at an excitation wavelength of 350 nm and emission wavelength of 440 nm in the presence of a template. Other variables affecting the fluorescence peaking were optimized using design expert software. The results illustrate that the use of PD@MIPs had a wide dynamic range 0.08-109 nmol L-1, good accuracy and detection limit of 0.02 nmol L-1, while using CQD@MIPs led to a lower dynamic range 0.36-64 nmol L-1, and detection limit of only 0.11 nmol L-1. The responses of the optical nanoprobe for acetamiprid in water (recovery 92-102%) and apple (recovery 92-103%) were also investigated. Graphical abstract Schematic representation of preparation polymer dots (PDs), carbon quantum dots (CQDs), PDs coated with imprinted polymers (PD@MIPs), and CQDs coated with imprinted polymers (CQD@MIPs) in the presence and absence of acetamiprid.A novel ammonia (NH3) chemical sensor is presented with ultra-high response, good selectivity, fast response, and long-term stability using detecting layer of polyaniline/cupric oxide nanoparticles supported on three-dimensional nitrogen-doped graphene-based frameworks (PANI/CuO@3D-NGF) nanocomposite. The NH3 gas sensing response of the PANI/CuO@3D-NGF nanocomposite was studied by resistivity method in low concentration range of 50 ppb-100 ppm at room temperature. The PANI/CuO@3D-NGF nanocomposite was prepared through in situ polymerization of PANI on the CuO@3D-NGF with a high surface area. Morphological and structural analysis revealed that the ultrathin 3D interconnected graphene substrate maximizes the surface area. It is also shown that the CuO nanoparticles offer active adsorption sites for free NH3 molecule. The PANI/CuO@3D-NGF nanocomposite gas sensor shows the response of 930% to 100 ppm NH3 with an outstanding low detection limit of 50 ppb and an average response time of 30 s at room temperature. The excellent sensing performance of the PANI/CuO@3D-NGF nanocomposite was attributed to 3D interconnected porous structure, remarkable enhancement of charge carriers as a result of CuO@3D-NGF, and modified π-interactions between molecules. Graphical abstract.PURPOSE This study aims at evaluating the effects of RTS (rotation softened trauma fixation system) compared with PCPSF (percutaneous conventional pedicle screw fixation) on type A thoracolumbar fractures. METHODS In this retrospective cohort study, 116 patients with type A thoracolumbar fractures from March 2014 to June 2018 were enrolled. PCPSF was performed in 60 patients, meanwhile the other 56 patients accepted RTS. VAS scores, Cobb angle, anterior vertebral height (AVH) and perioperative data were compared between the two groups. RESULTS Both groups were consistent with baseline on demographic and clinical characteristics. No significant difference was observed in VAS score between-group before and after operation. One year after surgery, the VAS score of RTS group was lower than that of PCPSF group (0.7 ± 0.3 vs. 1.5 ± 0.4). The postoperative AVH (%) in PCPSF was 82.3% (95%CI, 81.7-84.6), and 91.78% (95% CI, 91.1-92.4) in RTS. The postoperative improvement rate of AVH (%) in RTS was higher than that in PCPSF (30.