350, 5.327, p = 0.001) predicted autism severity. Auranofin chemical structure CONCLUSIONS AND IMPLICATIONS Children with ASD in this study had a high level of autism severity. Regular anthropometric measurements by healthcare professionals should be conducted at the autism intervention centres. It is important to have multidisciplinary collaboration in future research to develop customised guidelines for parents with autistic children. AIMS To examine the association between cannabis use and subsequent other illicit drug use and drug use disorders (harmful use and dependence). DESIGN, SETTING, PARTICIPANTS We used survey data from a population-based cohort in Stockholm County (collected 1998-2000), with linkage to the National Patient Register. The study base comprised participants aged 20-64 years (N = 10 345), followed-up until 2014. Cox and logistic regression analyses were conducted to test associations between self-reported cannabis use and risk of subsequent other illicit drug use (three-year follow-up) and drug use disorders (16-year follow-up). FINDINGS The odds ratio (OR) for other illicit drug use onset at three-year follow-up for lifetime cannabis users was 7.00 (4.47-10.35, 95% CI) and for recent cannabis users 34.41 (19.14-61.88, 95% CI). Adjusting for age and AUDIT score attenuated the association, for lifetime users OR = 5.48 (3.69-8.13, 95% CI) and OR = 5.65 (3.80-8.41, 95% CI), and for recent users OR = 18.32 (9.88-33.99, 95% CI) and OR = 20.88 (11.19-38.95, 95% CI). For cannabis users only, the hazard ratio (HR) for drug use disorders at 16-year follow-up was 0.89 (0.31-2.61, 95%CI). For cannabis and other illicit drug users, the corresponding HR was 7.27 (3.85-13.75, 95% CI). CONCLUSIONS There was no independent association between cannabis use and subsequent drug use disorders. The association with subsequent drug use disorders was rather explained by other illicit drug use, which cannabis users were at higher risk of at the three-year follow-up. PURPOSE The purpose of this study was to identify healthcare providers’ experiences of the gaps in the healthcare system, barriers to obtaining care, and facilitators that promoted safe, quality care for family caregivers of children with respiratory diseases. DESIGN AND METHODS A qualitative, descriptive design was used with 13 pediatric healthcare providers. FINDINGS Gaps included themes of 1) fragmented healthcare system and 2) lack of asthma management knowledge. Barriers included themes of 1) poor access to healthcare and medications, 2) non-adherence, and 3) linguistic diversity and poor health literacy. Facilitators of optimal respiratory management included themes of 1) education, 2) improved communication, and 3) peer support. CONCLUSIONS Through better understanding the gaps, barriers, and facilitators, pediatric nurses will be able to more effectively anticipate and address the needs of the caregivers. PRACTICE IMPLICATIONS The nurse is in a pivotal role to empower caregivers with the skills and resources to address challenges and connect them with providers for optimal respiratory management. Numerous studies have shown that post-learning sleep enhances visual episodic recognition memory. However, it remains unclear whether this consolidation benefit is moderated by the emotional valence of the learned material. To clarify whether sleep selectively enhances memory for emotional material, we conducted a meta-analysis including N = 1059 post-sleep/wake observations. Overall, our results do not support this hypothesis. When only studies with a sleep group/wake group comparison were included in the analysis (k = 22), the retention advantage for emotional (negative/positive) over neutral material was not significantly different between sleep and wake groups. When studies without wake groups were included in the analysis after statistical estimation of wake-group parameters, the retention advantage for emotional material was significantly larger in wake groups than in sleep groups (k = 34). Interestingly, however, an additional analysis of eight studies investigating the selective effects of rapid-eye-movement sleep and slow-wave sleep on post-interval emotional memory provided evidence for a selective enhancement of emotional over neutral memory performance after rapid-eye-movement sleep compared to slow-wave sleep. These findings suggest that sleep does not generally enhance visual recognition memory for emotional stimuli. However, the result pattern is consistent with the idea that specific sleep stages preferentially enhance consolidation of emotional and neutral material, respectively. This systematic review and meta-analysis 1) clarifies and quantifies existing results on the association between exposure to workplace bullying and sleep, 2) evaluates the methodological quality of existing studies, 3) identifies theoretical frameworks used in research, 4) determines moderating and mediating variables, and 5) provides guidelines for future research. Searches for primary studies were conducted in Pubmed, Medline, Embase, PsycINFO and Web of Science. Of the 406 studies identified, 26 fulfilled the inclusion criteria for the qualitative synthesis whereas sixteen studies were included in the meta-analysis (cross sectional effect sizes 15; N = 69,199/prospective effect sizes 6; N = 26,164). Workplace bullying was significantly related to sleep problems in all studies. Across cross-sectional studies, targets of bullying had 2.31 higher odds of reporting sleep problems compared to non-bullied workers. The odds across the prospective studies was 1.62. The quality of evidence for the association between workplace bullying and sleep problems was low to moderate. Only eight studies had a predefined theoretical rationale for the association, and few studies examined mediating and moderating variables or bidirectional associations. The methodological quality of the studies was moderate. Further research is needed to establish the nature, directionality, mechanisms, and conditions of the association between bullying and sleep. The membrane binding behaviors of beta-amyloid fibrils, dimers to pentamers, from solution to lipid raft surfaces, were investigated using coarse-grained (CG) MD simulations. Our CG rafts contain phospholipid, cholesterol (with or without tail- or headgroup modifications), and with or without asymmetrically distributed monosialotetrahexosylganglioside (GM1). All rafts exhibited liquid-ordered (Lo), liquid-disordered (Ld), and interfacial Lo/Ld (Lod) domains, with domain sizes depending on cholesterol structure. For rafts without GM1, all fibrils bound to the Lod domains. Specifically, dimer fibrils bound exclusively via the C-terminal, while larger fibrils could bind via other protein regions. Interestingly, a membrane-inserted state was detected for a trimer fibril in a raft with tail-group modified cholesterol. For rafts containing GM1, fibrils bound either to the GM1-clusters, with numerous membrane-bound conformations, or to the non-GM1-containing-Lod domains via the C-terminal. Our results indicate beta-amyloid fibrils bind to Lod domains or GM1, with diversified membrane-bound conformations, in structurally heterogeneous lipid membranes.