Periploca aphylla is used by local population and indigenous medicine practitioners as stomachic, tonic, antitumor, antiulcer, and for treatment of inflammatory disorders. The aim of this study was to evaluate antidiabetic effect of the extract of P. aphylla and to investigate antioxidant and hypolipidemic activity in streptozotocin (STZ)-induced diabetic rats.

The present research was conducted to evaluate the antihyperglycemic potential of methanol extract of P. aphylla (PAM) and subfractions n-hexane (PAH), chloroform (PAC), ethyl acetate (PAE), n-butanol (PAB), and aqueous (PAA) in glucose-overloaded hyperglycemic Sprague-Dawley rats. Based on the efficacy, PAB (200 mg/kg and 400 mg/kg) was tested for its antidiabetic activity in STZ-induced diabetic rats. Diabetes was induced via intraperitoneal injection of STZ (55 mg/kg) in rat. Blood glucose values were taken weekly. HPLC-DAD analysis of PAB was carried out for the presence of various polyphenols.

HPLC-DAD analysis of PAB recorded the presence olt; 0.01) of above parameters, and results were comparable to that of standard drug glibenclamide.

The result suggests the antihyperglycemic, antioxidant, and anti-inflammatory activities of PAB treatment in STZ-compelled diabetic rat. PAB might be used as new therapeutic agent in diabetic patients to manage diabetes and decrease the complications.

The result suggests the antihyperglycemic, antioxidant, and anti-inflammatory activities of PAB treatment in STZ-compelled diabetic rat. PAB might be used as new therapeutic agent in diabetic patients to manage diabetes and decrease the complications.

Published research informs international healthcare, yet only a few studies have assessed the representation of authors, editors, and research from developing countries in biomedical journals.

We reviewed all research articles published in five high-ranking peer-reviewed neurology journals (The Lancet Neurology, Acta Neuropathologica, Nature Reviews Neurology, Brain and Annals of Neurology) in 2010 and 2019 to determine the extent of contributions of authors, editors and research from developing countries, and the degree of international research collaboration between developed and developing countries.

First authorship was attributed to authors from developing countries in only 2% (11/729) of research articles in 2010 and 3% (19/647) of research articles in 2019. All 144 editorial board members in 2019 were from developed countries. International research collaboration between developing and developed countries accounted for only 4% (30/729) of all research articles in 2010 and 6% (40/647) of all research articles in 2019.

There is urgent need for strategies to support high-quality and contextually appropriate biomedical research in developing countries. Supporting high quality and contextually appropriate biomedical research now is necessary for developing countries to meet the rising healthcare needs of their populations in the future.

There is urgent need for strategies to support high-quality and contextually appropriate biomedical research in developing countries. Supporting high quality and contextually appropriate biomedical research now is necessary for developing countries to meet the rising healthcare needs of their populations in the future.

To evaluate the overall functional and audiological benefits in unilateral hearing loss, as well as performance improvements with Cochlear™ Baha® Attract System with Baha® 5 sound processor.

We performed a prospective study. Epalrestat in vitro Fourteen consecutive adult patients with unilateral hearing loss who were audiologically eligible for Baha® Attract were included in this study. All patients were followed-up, and a series of tests were performed in the sound field before surgery, one, two, three, and 6 months after surgery.

Patients were categorized based on their hearing impairment type and severity. Ten patients had conductive hearing loss (CHL), or mixed hearing loss (MHL), and four patients had sensorineural hearing loss (SNHL). The hearing threshold in the sound field aided with Baha® Attract was similar to the preoperative bone conduction hearing threshold of the better ear. The results of the speech audiometry improved post-operatively, but they did not match that of the better ear before surgery. The overall score of the hearing-in-noise test was gradually improved from one month to 6 months after surgery. The results of the sound localization test for SNHL patients were not as good as those for CHL or MHL. All the questionnaires demonstrated additional benefits that implied performance improvements.

The Baha® Attract provides enough auditory benefits and performance improvements for hearing impaired patients, though there are different benefits according to the type of hearing loss. Clinicians need to counsel the unilateral hearing loss patients for Baha® Attract System carefully, according to their type of hearing loss.

The Baha® Attract provides enough auditory benefits and performance improvements for hearing impaired patients, though there are different benefits according to the type of hearing loss. Clinicians need to counsel the unilateral hearing loss patients for Baha® Attract System carefully, according to their type of hearing loss.Objective Subjective social status (SSS) has largely been ignored within psychotherapy literature. We investigated the association between similarities in client-clinician perceptions of SSS, similarities in their report of the quality of working alliance, and resultant anxiety symptoms. Method Participants represented a primarily low-income, culturally diverse sample of 312 clients receiving care from 68 clinicians at 13 outpatient mental health clinics in the Northeastern United States between September 2013 and August 2016. As part of a larger randomized controlled trial, clients and clinicians completed the MacArthur Scale of subjective social status and the Working Alliance Inventory (WAI), and clients completed the Generalized Anxiety Disorder 7-item Scale (GAD-7). Results At the within-clinician level, client-clinician dyads with less similar perceptions of the client’s SSS were characterized by less similar perceptions of their alliance, which in turn resulted in worsening anxiety symptoms. Conclusion Clinicians’ correct perception of their clients’ social status might be important for sharing a similar view of the client-clinician level of alliance, which can, in turn, contribute to lowering the client’s anxiety symptoms.