From an early age, children develop stereotypes toward older adults leading to potential ageism. In young adults, ageism includes conversational changes, also known as elderspeak, characterized by louder, slower, and simplified speech. Although it has direct consequence on older adults, to date no studies have explored elderspeak in children. We invited 137 Belgian children aged 7-12 to take part in a guessing game through a dissimulated Skype session. The child had to make two female interlocutors in turn, one young (25 years old) and the other old (75), guess two different words each. During the session, children remained unaware of the real purpose of the game. Prosody, verbal fluency, and semantic content of their speech were measured using the Praat and VocabProfil software. The results, analyzed using mixed-design ANOVA, showed that children spoke louder to the older interlocutor and tended to judge her less competent to guess words than the younger participant. When the older person was second in turn, children engaged in lengthier and more detailed explanations. Unexpectedly, positive views on older people correlated with higher voice intensity, suggesting that the child’s differential vocal attitudes may reflect benevolent ageism. In conclusion, significant speech accommodation can be detected in 7- to 12-year-old children when they speak to an older compared with a younger interlocutor. This accommodation is characterized by louder voice and lengthier explanations. © 2020 John Wiley & Sons Ltd.OBJECTIVES This study sought to investigate the relation between left ventricular end-diastolic pressure (LVEDP) and outcomes in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS). BACKGROUND Risk stratification in ACS patients is important. Data on the role of LVEDP in the prognostication of ACS patients are scarce. METHODS A total of 1,410 patients undergoing PCI for ACS and with available data on LVEDP were divided according to LVEDP tertiles (lowest tertile ≤13 mmHg, intermediate tertile 14-20 mmHg, and highest tertile >20 mmHg). The primary endpoint was all-cause mortality at a median follow-up of 246 [28-848] days. RESULTS Median LVEDP was 16 (11-22) mmHg. All-cause mortality was 2.8%, 4.5%, and 15.0% in the lowest, the intermediate, and the highest LVEDP tertile groups (p  less then  .001), respectively. Belonging to the highest LVEDP tertile was associated with an increased risk of all-cause mortality (adjusted hazard ratio [HR] = 2.66, 95% confidence interval [CI] [1.30, 5.47], p = .008). By receiver operating characteristic curve analysis, the optimal cut-off value for predicting all-cause mortality was 20 mmHg (sensitivity 68.3%, specificity 72.5%). There was no differential effect of LVEDP on mortality in patients with and without LV dysfunction (interaction p = .23) or ST-elevation myocardial infarction as index ACS event (interaction p = .86). selleckchem CONCLUSIONS In patients undergoing PCI for ACS, LVEDP was independently related with mortality. Hence, LVEDP should be incorporated into early risk stratification and clinical decision making of ACS patients. © 2020 Wiley Periodicals, Inc.Considering the problems of high costs, low catalytic activity and selectivity in the metal-based catalysts for CO2 electroreduction, we apply boron-containing metal-free B2 S sheet as an alternative to the traditional metal-based catalysts. Reaction energy calculations identify the preferred “Formate” pathway for CO2 conversion to CH3 OH on B2 S, in which the thermodynamic energy barrier obtained by using the Computational Hydrogen Electrode model is 0.57 eV, and the kinetic energy barrier obtained by searching the transition states is 1.18 eV. Another possible reaction pathway, “RWGS+CO-hydro”, is suppressed and the hydrogen evolution reaction (HER) side reaction is nonspontaneous. Compared to Cu(211) with the highest catalytic activity among all transition metals, B2 S sheet exhibits a better catalytic activity with a lower overpotential for CO2 reduction and a better selectivity that suppresses the non-target reaction. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.BACKGROUND Peptide receptor radionuclide therapy (PRRT) is effective for treating midgut neuroendocrine tumors (NETs); however, incorporation of PRRT into routine practice in the U.S. is not well studied. Herein we analyze the first year of PRRT implementation to determine tolerance of PRRT and factors that increase risk of PRRT discontinuation. MATERIALS AND METHODS Medical records were reviewed and data were abstracted on all patients with NETs scheduled for PRRT during the first year of PRRT implementation at a U.S. NET referral center (August 2018 through July 2019). Logistic regression was used to identify factors associated with PRRT discontinuation. RESULTS Fifty-five patients (56% male) were scheduled for PRRT over the study period. The most common primary NET location was small bowel (47%), followed by pancreas (26%), and 84% of the NETs were World Health Organization grade 1 or 2. The cohort was heavily pretreated with somatostatin analog (SSA) therapy (98%), non-SSA systemic therapy (64%), primary 21% of individuals prematurely discontinued PRRT. Patients with baseline liver function test abnormalities were more likely to discontinue PRRT than patients with normal liver function tests, which should be taken into consideration when selecting treatment options for NETs. © AlphaMed Press 2020.Individuals in free-living animal populations generally differ substantially in reproductive success, lifespan and other fitness-related traits and the molecular mechanisms underlying this variation are poorly understood. Telomere length and dynamics are candidate traits explaining this variation, as long telomeres predict a higher survival probability and telomere loss has been shown to reflect experienced “life stress”. However, telomere dynamics among very long-lived species are unresolved. Additionally, it is generally not well understood how telomeres relate with reproductive success or sex. We measured telomere length and dynamics in erythrocytes to assess their relation to age, sex and reproduction in Cory’s Shearwaters (Calonectris borealis), a long-lived seabird, in the context of a long-term study. Adult males had on average 231 bp longer telomeres than females independent of age. In females, telomere length changed relatively little with age, whereas male telomere length declined significantly. Telomere shortening within males from one year to the next was three times higher than the inter-annual shortening rate based on cross-sectional data of males.