Other favorite features, including superior biocompatibility, weak dark toxicity, and mitochondria enrichment capability, are implemented. All these traits not only afford nanoprobe precision tumor cell targeting capability but also provide promising imaging-guided antitumor therapy. We believe that the single molecular protocol will establish a novel strategy for simultaneous diagnosis and anticancer medicine treatment utilizing versatile but small compounds.A combination of chemotherapy and targeted magnetic hyperthermia (TMH) via a designed magnetic nanocrystal (MNC) drug delivery system was considered as an effective tumor synergistic therapy strategy. In this paper, we successfully synthesized tumor neovascular-targeted Mn-Zn ferrite MNCs, which encapsulated paclitaxel (PTX) in a biocompatible PEG-phospholipid (DSPE-PEG2000) layer and surface, simultaneously coupled with a tripeptide of arginine-glycine-aspartic acid (RGD). The high-performance RGD-modified MNC loaded with PTX (MNCs-PTX@RGD) embodied excellent magnetic properties, including high-contrast magnetic resonance imaging (MRI) and remarkable magnetically induced heat generation ability. We established the mouse model bearing subcutaneous 4T1 breast tumor, and demonstrated that MNCs-PTX@RGD could be effectively located in the tumor neovascular epithelial cells under the guidance of in vivo MRI. Notably, MNCs-PTX@RGD could easily penetrate into the tumor tissue from the tumor-fenestrated vascular networks for capturing a sufficient temperature (around 43 °C) exposed to an alternative current magnetic field (ACMF, 2.58 kA m-1, 390 kHz), leading to an effective TMH effect. Subsequently, the TMH-mediated temperature elevation accelerated the PTX release from the inner lipid layer, promoting the synergetic thermo-chemotherapy in vivo. The amplifying synergistic treatment strategy obviously improved the anti-tumor efficacy of MNCs-PTX@RGD, and simultaneously increased the survival time of the mice to more than 46 days, which provided a broad development prospect in clinical applications.Finding photocatalysts that fully utilize the visible solar light to split water into hydrogen and oxygen has been a challenging problem for a long time. SHR-3162 cell line In this regard, compared to traditional three-dimensional materials, graphene-like two-dimensional materials offer many advantages such as ultra-high surface area for photochemical reactions and minimal migration distance for carriers. Herein, using density functional theory (DFT), we examine the potential of a new series of two-dimensional boron chalcogenides, B2X3 (X = S, Se, Te) as candidates for such photocatalysts. We show that B2Se3 and B2Te3 possess the ideal energy levels for photon excitation for both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Furthermore, a bilayer van der Waals heterostructure consisting of B2Te3/B2Se3 is found to have the greatest potential for two-step photo-excitation for water splitting reaction. Our results can stimulate the synthesis of new two dimensional materials for photocatalysis.The aim of this study was to evaluate the bioaccessibility of (poly)phenolic compounds in Tudela artichokes (Cynara scolymus cv. Blanca de Tudela) after an in vitro gastrointestinal digestion and the effect of the human colonic microbiota. A total of 28 (poly)phenolic compounds were identified and quantified by LC-MS/MS in raw, boiled, sous vide and microwaved Tudela artichokes. Out of these, sixteen were phenolic acids, specifically caffeoylquinic acids (CQAs) and other minor hydroxycinnamic acid derivatives, ten flavonoids belonging to the family of flavones (apigenin and luteolin derivatives) and two lignans (pinoresinol derivatives). Sous vide and microwaving caused mainly transesterification reactions of CQAs but maintained or even augmented the total (poly)phenolic contents of artichokes, while boiling decreased (poly)phenolic compounds by 25% due to leaching into the boiling water. Heat treatment exerted a positive effect on the bioaccessibility of (poly)phenols after gastrointestinal digestion. In raw artichokes, only 1.6% of the total (poly)phenolic compounds remained bioaccessible after gastrointestinal digestion, while in artichoke samples cooked by sous vide, boiled and microwaved, the percentage of bioaccessibility was 60.38%, 59.93% and 39,03% respectively. After fecal fermentation, 20 native (poly)phenolic compounds and 11 newly formed catabolites were quantified. 48 h of fecal fermentation showed that native (poly)phenols are readily degraded by colonic microbiota during the first 2 h of incubation. The colonic degradation of artichoke (poly)phenols follows a major pathway that involves the formation of caffeic acid, dihydrocaffeic acid, 3-(3′-hydroxyphenyl)propionic acid, 3-phenylpropionic acid and phenylacetic acid, with 3-phenylpropionic acid being the most abundant end product. The catabolic pathways for colonic microbial degradation of artichoke CQAs are proposed.A dielectric polymer with high energy density is in high demand in modern electric and electronic systems. The current polymer dielectrics are facing the tradeoff between high energy density and low energy loss. Although many efforts have been devoted to solving the problem by modifying biaxially oriented polypropylene (BOPP), poly(vinylidene fluoride) (PVDF) and glassy polymers, limited success has been achieved. In the present work, we disperse the high polar nitrile units in a low polar polystyrene (PSt) matrix to avoid the strong coupling force among the adjacent polar groups and reduce the relaxation-induced high dielectric loss. In addition, the possible charge transportation offered by phenyl groups could be blocked by the enlarged bandgap. Notably, the induced polarization is established between the nitrile and phenyl groups, which may lead to the copolymer chain being more densely packed. As a result, excellent energy storage performances, including the high energy density and low loss, are achieved in the resultant poly(styrene-co-acrylonitrile) (AS). For instance, AS-4 exhibits a Ue of 11.4 J cm-3 and η of 91% at ambient temperature and 550 MV m-1. Manipulating the dipole polarization in the low polar glassy polymer matrix is verified to be a facile strategy for the design of a high-energy storage dielectric polymer.