Human metapneumovirus (HMPV) is an important human pathogen that, along with respiratory syncytial virus (RSV), is a major cause of respiratory tract infections in young infants. Development of an effective vaccine against Pneumoviruses has proven to be particularly difficult; despite over 50 years of research in this field, no vaccine against HMPV or RSV is currently available. Recombinant chimeric viruses expressing antigens of other viruses can be generated by reverse genetics and used for simultaneous immunization against more than one pathogen. This approach can result in the development of promising vaccine candidates against HMPV, and several studies have indeed validated viral vectors expressing HMPV antigens. In this review, we summarize current efforts in generating recombinant chimeric vaccines against HMPV, and we discuss their potential optimization based on the correspondence with RSV studies.The world of sports has a complex association to problem gambling, and the sparse research examining problem gambling in athletes has suggested an increased prevalence and particularly high male predominance. The present study aimed to study frequency and correlates of problem gambling in populations with moderate to high involvement in fitness or physical exercise. This is a self-selective online survey focusing on addictive behaviors in physical exercise distributed by ‘fitness influencers’ on social media and other online fitness forums to their followers. CC115 Respondents were included if they reported exercise at least thrice weekly, were above 15 years of age, and provided informed consent (N = 3088). Problem gambling, measured with the Lie/Bet, was studied in association with demographic data, substance use, and mental health variables. The occurrence of lifetime problem gambling was 8 percent (12 percent in men, one percent in women). In logistic regression, problem gambling was associated with male gender, younger age, risky alcohol drinking, obsessive-compulsive disorder, and less frequent exercise habits. In conclusion, in this self-recruited population with moderate to high fitness involvement, problem gambling was moderately elevated. As shown previously in elite athletes, the male predominance was larger than in the general population. The findings strengthen the link between problem gambling and the world of sports.The aim of the present study was to investigate antioxidant, angiotensin converting enzyme (ACE) inhibitory, and anti-microbial activities of wheat wafers enriched with 1%, 2%, or 3% (w/w) of millet flour (M1, M2, or M3, respectively). All samples were characterized by a richer composition of protein, polyphenols, flavonoids, phenolic acids, and reducing sugar in comparison with the control sample. The highest content of the components, i.e., 1.03 mg mL-1, 0.021 mg mL-1, 2.26 mg mL-1, 0.17 µg mL-1, and 0.63 mg mL-1, respectively, was detected in sample M3. The same sample was characterized by 803.91 and 42.79% of water and oil absorption capacity, respectively. The additive did not change the rheological features of the wafers. The 3% addition of millet flour to the wafer formulation induced the highest antioxidant activity against DPPH, Fe2+ chelation, and ACE inhibitory activity of hydrolysates (IC50 = 191.04, 0.46, and 157.73 µg mL-1, respectively). The highest activities were determined in the M3 fraction less then 3.0 kDa (IC50 = 3.46, 0.26, and 16.27 µg mL, respectively). In turn, the M2 fraction was characterized by the highest antimicrobial activity against Listeria monocytogenes with a minimum inhibitory concentration (MIC) value of 75 µg mL-1.Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is a genetic disorder that results from the aberrant metabolism of the neurotransmitter γ-amino butyric acid (GABA). The disease is caused by impaired activity of the mitochondrial enzyme succinic semialdehyde dehydrogenase. SSADH-D manifests as varying degrees of mental retardation, autism, ataxia, and epileptic seizures, but the clinical picture is highly heterogeneous. So far, there is no approved curative therapy for this disease. In this review, we briefly summarize the molecular genetics of SSADH-D, the past and ongoing clinical trials, and the emerging features of the molecular pathogenesis, including redox imbalance and mitochondrial dysfunction. The main aim of this review is to discuss the potential of further therapy approaches that have so far not been tested in SSADH-D, such as pharmacological chaperones, read-through drugs, and gene therapy. Special attention will also be paid to elucidating the role of patient advocacy organizations in facilitating research and in the communication between researchers and patients.Tridimensional cubic mesoporous silica, SBA-16, functionalized with aminopropyl groups, were employed as adsorbents for Pb2+ ion removal from aqueous solution. The adsorption capacity was investigated for the effect of pH, contact time, temperature, and concentration of 3-aminopropyltriethoxysilane (APTES) employed for adsorbent functionalization. The textural properties and morphology of the adsorbents were evaluated by N2 physisorption, small-angle X-ray diffraction (XRD), diffuse reflectance spectroscopy (UV-vis), and transmission electron microscopy (TEM). The functionalization of the SBA-16 was evaluated by elemental analysis (N), thermogravimetric analysis (TG), Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). Batch adsorption studies show that the total Pb2+ ions removal was archived on adsorbent having an optimized amount of aminopropyl groups (2N-SBA-16). The maximum of Pb2+ ions removal occurred at optimized adsorption conditions pH = 5-6, contact time 40 min, and at a low initial lead concentration in solution (200 mg L-1). Under the same adsorption conditions, the amino-functionalized SBA-16 with cubic 3D unit cell structure exhibited higher adsorption capability than its SBA-15 counterpart with uniform mesoporous channels.Zeolite-based catalysts are globally employed in many industrial processes, such as crude-oil refining and bulk chemical production. In this work, the cracking of low-density polyethylene (LDPE) was thoroughly followed in a FTIR operando study to examine the catalytic efficiency of purely microporous zeolites of various textural characteristics. To provide complementary and valuable information on the catalytic activity of the zeolite studied, the thermogravimetric analysis results were compared with yields of the products generated under operating conditions. The reaction products were analyzed via GC-MS to determine the hydrocarbon chain distribution in terms of paraffin, olefins, and aromatics. The individual impact of textural and acidic parameters on catalytic parameters was assessed. The accumulation of bridging hydroxyls of high strength in the zeolite benefited the decrease in polymer decomposition temperature. Through a strategic comparison of purely microporous zeolites, we showed that the catalytic cracking of LDPE is dominated by the acidic feature inherent to the microporous environment.