The aim of this study was to compare the efficacy of surgery combined with conventional chemoradiotherapy in the treatment of limited-stage small cell lung cancer (LS-SCLC), and analyze the factors affecting prognosis.

A total of 122 LS-SCLC patients were diagnosed via histopathology, of which 61 were operated combined with chemoradiotherapy (comprehensive treatment group), and 61 underwent conventional chemoradiotherapy (chemoradiotherapy group). The Kaplan-Meier method wand log-rank test were used to analyze the overall survival of the patients. Cox proportional hazard regression model was utilized for multivariate analysis of prognosis.

The median survival time of the patients was 27 months in the comprehensive treatment group and 22 months in chemoradiotherapy group. The 1-, 3- and 5-year survival rates were 91.8% (56/61), 49.2% (30/61) and 31.1% (19/61), respectively, in the comprehensive treatment group, and 80.3% (49/61), 32.8% (20/61) and 23.0% (14/61), respectively, in the chemoradiotherapy groor the patients at stage III. TNM stage is an independent factor affecting the prognosis of LS-SCLC.

To search the AKR1C3 and β-catenin expression in non-small cell lung cancer (NSCLC) and to explore the correlation between AKR1C3 and β-catenin and radiation resistance.

Paraffin specimens from 61 patients with NSCLC were evaluated. These patients could not receive operation but received radical radiotherapy. The patients were divided into effective group and ineffective group with reference to RECIST evaluation criteria. The sites and intensity of AKR1C3 and β-catenin protein expression were detected by immunohistochemistry. The relationship between AKR1C3 and β-catenin and radiation resistance was analyzed by Mann-Whitney U test. The correlation between AKR1C3 and β-catenin was analyzed by Spearman’s correlation test. Mann-Whitney U test was used to analyze the AKR1C3 overall expression in the effective group and the ineffective group after radiotherapy.

The nuclear expression in the two groups was statistically significant (p=0.033). The β-catenin protein was mainly expressed in the cytoplasm and thesistance, and the higher the β-catenin nuclear expression, the worse the short-term curative effects after radiotherapy. The nuclear aggregation of AKR1C3 during radiation resistance of non-small cell lung cancer (NSCLC) may have some synergistic relationship with nuclear aggregation of β-catenin.

Prolongation of radiotherapy worsens the results of treatment of head and neck squamous cell carcinoma (HNSCC). The purpose of this study was to identify the prognostic factors most affected by the prolongation of treatment.

184 patients with locally advanced HNSCC were treated with curative chemo-radiation using SIB-IMRT from 2008 to 2016 and the influence of radiotherapy time (RTT) in groups of patients according to prognostic factors was retrospectively evaluated.

Median overall survival (OS) was 45 months, median disease-free survival (DFS) was 41 months and median local control (LC) was not reached (mean LRC 68 months). In the multivariate analysis the radiotherapy prolongation negatively affected the LC in stage IV patients, T3/T4, in neck nodes positive disease, in oropharyngeal and oral cavity cancers, after neoadjuvant chemotherapy and in men. The RTT effect on DFS was significant in stage IV patients, patients with neck nodes positive disease and oropharyngeal cancer. RTT prolongation decreased OS within the groups of stage IV and grade 3 tumours.

Prolonged RTT was associated with worsened OS and LRC, especially in stage IV patients and/or neck node positive disease and/or oropharyngeal cancer and we recommend that these patients should be prioritized in treatment gap compensation in radical radiotherapy for locally advanced HNSCC.

Prolonged RTT was associated with worsened OS and LRC, especially in stage IV patients and/or neck node positive disease and/or oropharyngeal cancer and we recommend that these patients should be prioritized in treatment gap compensation in radical radiotherapy for locally advanced HNSCC.

The purpose of this study was to investigate the effect of miR-183 on the sensitivity of laryngeal cancer cells to 5-fluorouracil (5-Fu) and its mechanism, so as to provide certain references for the clinical prevention of drug resistance in laryngeal cancer cells.

Cell proliferation was determined via 5-ethynyl-2′-deoxyuridine (EdU) staining. Colony formation assay was applied to test the colony-formation ability in each group of cells. In addition, the expression levels of apoptosis-related proteins were measured through Western blotting. Wound-healing assay and Transwell assay were performed to examine the migratory and invasive abilities. Furthermore, the tumor-forming ability in vitro was detected by subcutaneous tumor formation assay.

MiR-183 declined remarkably in 5-Fu-RES group compared with that in Control group. selleck chemical After overexpressing miR-183, the DNA replication and colony forming abilities of the resistant human primary laryngeal cancer cells were weakened notably. MiR-183 overexpression could5-Fu, promote cancer cell apoptosis and inhibit their invasive and migratory abilities at the same time, whose mechanism may be associated with the targeted regulation of the TBX3/PTEN signaling pathway by miR-183.

To describe a new technique of surgical treatment of the lip commissure or buccal mucosa carcinomas, where we use local flaps (skin, buccal mucosa) of the sliding type.

According to the current technique, the ectomy ranges horizontally and in a cuneiform shape towards the side of the buccal cavity, and in the whole thickness of the layer (skin – mucosa), where the neoplastic focus is enclosed.

The difference in our technique consists of the following To the vertical bi-cuneiform part of the wound a horizontal cuneiform part (with the top showing upwards) is added, with extent and width analogous to those of the cancerous injury (tri-cuneiform ectomy). The width of the gap across its horizontal part is larger on the side of the mucosa (continuous line), compared to the one along the side of the skin (punctuated line), since the mucosa, as a more versatile tissue, can be sutured easily, in contrast to the buccal skin, which is of greater thickness and shows lack of versatility, so that it can be pulled on with difficulty in order to be sutured.