Although rare in pregnant women, it is critical to consider the possibility of DM and PM in patients presenting with rash, fever, weakness, and cough, and testing for myositis-specific autoantibodies is recommended.Thailand is one of the largest contributors to plastic waste in the oceans. Since mismanaged plastic waste can enter the ocean via inland waterways, microplastic contamination in freshwater used for tap water production has been raised as a potential issue. This study was conducted to determine the abundance and characteristics of microplastics in freshwater and treated tap water in Bangkok. Freshwater and treated water were collected from the eastern and western water supply systems in the dry and wet seasons. The source waters of the eastern and western water supply systems are the Chao Phraya River and Maeklong River, respectively. Approximately 0.40-2.40 particles/L microplastics was determined in the freshwater samples. No significant differences in microplastic abundance with respect to water supply system or season were found. Approximately 82.1% of the total microplastics found in the freshwater were smaller than 300 µm in size. The percentage contribution of various microplastic size ranges decreased with increasing size. The majority of microplastics found in freshwater were fragments (90.2%), colorless (64.3%), and made of polyethylene polymer (45.1%). Only the eastern water supply system was capable of removing microplastic particles (27.7%) from freshwater. The identification of microplastics larger than 100 µm in size in the treated tap water indicated potential contamination from microplastics in the treatment system, particularly after the sand filtration unit. The major characteristics of the microplastics found in treated tap water were similar to those found in freshwater, with 85.6% fragments, 85.1% colorless, and 47.9% made of polyethylene polymer.This article presents a case of sudden bilateral deafness in the context of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection and resultant coronavirus disease 2019 (COVID-19). After treatment in the intensive care unit for acute respiratory distress syndrome and acute kidney failure, hearing ability had drastically changed. While hearing had been subjectively normal before the infection, deafness was now measured on the left and profound hearing loss on the right ear. The patient was treated with cochlea implants on the left and a hearing aid in the right ear. Cariprazine The hearing loss is most likely a complication of COVID-19.

Recurrent and residual laryngeal cancer after organ-preserving radio- or radiochemotherapy is associated with apoor prognosis. Salvage surgery is the most important therapeutic option in these cases.

The study assessed rates of recurrence and residual tumor as well as survival and complication rates after salvage laryngectomy at the authors’ academic cancer center.

Aretrospective examination of all patients receiving laryngectomy between 2001 and 2019 due to tumor residuals or recurrence after primary radio- and radiochemotherapy was conducted.

A total of 33salvage procedures were performed. Defect reconstruction was performed by free flap surgery in 30.3% (n = 10) and regional flap surgery in 15.2% (n = 5) . One patient received regional flap surgery and free flap surgery simultaneously. Overall survival after 1, 2, and 5years was 68.7, 47.9, and 24.2%, and disease-free survival was 81.6, 47.8, and 24.2%, respectively, with 48.5% (n = 16) postoperative tumor recurrences overall. Disease-free survival was significantly shorter for tumor extension into or onto the hypopharynx (p = 0.041). Postoperatively, 72.7% of patients developed apharyngocutaneous fistula, of which 24.2% required surgical treatment. The hospital stay was 28.0 ± 16.1 days.

Salvage laryngectomy is associated with ahigh rate of treatable complications and high morbidity. Nevertheless, considering the advanced tumor stages treated, it allows for respectable oncological results.

Salvage laryngectomy is associated with a high rate of treatable complications and high morbidity. Nevertheless, considering the advanced tumor stages treated, it allows for respectable oncological results.

Discovery of two rust resistance genes, R

and R

, from the sunflower lines introduced from South Africa and genetic mapping of them to sunflower chromosome 13. Rust, caused by the fungus Puccinia helianthi Schw., is one of the most serious diseases of sunflower in the world. The rapid changes that occur in the virulence characteristics of pathogen populations present a continuous threat to the effectiveness of existing rust-resistant hybrids. Thus, there is a continued need for the characterization of genetically diverse sources of rust resistance. In this study, we report to identify two new rust resistance genes, R

and R

, from the sunflower lines, KP193 and KP199, introduced from South Africa. The inheritance of rust resistance was investigated in both lines using two mapping populations developed by crossing the resistant plants selected from KP193 and KP199 with a common susceptible parent HA 89. The F

populations were first genotyped using genotyping by sequencing for mapping of the rust genesximal to R17 at 0.7 cM. R18 co-segregated with the SNP marker SFW04317 and was proximal to two cosegregating SNPs, SFW01497 and SFW05453, at 1.9 cM. These maps provide markers for stacking R17 or R18 with other broadly effective rust resistance genes to extend the durability of rust resistance. The relationship of the six rust resistance genes in the cluster was discussed.

Osteoarthritis (OA)-the progressive degeneration of synovial joints-is aworldwide problem that affects society, is associated with age and is the dominant reason for pain and immobility of the locomotor system. In the population, 70% of people over the age of 70show some signs of OA. Overall, up to 25% of the total population is affected, due to the general aging of the population itself, and this is an increasing tendency. However, in people over the age of 40the incidence of OA is already rising due to posttraumatic or secondary forms, like dysplasia, malalignment and other background factors.

There is ahigh need for mobility and sports in all generations, so the demands on the joints are high, especially if early degenerative changes are already present. Orthopaedic physicians are challenged with the limited load capacity, pain and the progressive joint problems, on the one hand to get the patient back to full mobility, and, on the other, to prevent early joint replacement. Early diagnosis and preventive measurements, as well as conservative treatments-from medication to braces-are necessary to achieve symptom-free movement and joint preservation to avoid joint replacement.