Circulating gonadal hormones have been linked to variation in the structure and function of the adult human brain, raising the question of how cognition is affected by sex hormones in adulthood. The impacts of progestogens and estrogens are of special interest due to the widespread use of hormone supplementation. Multiple studies have analyzed relationships between ovarian hormones and mental rotation performance, one of the largest known cognitive sex differences; however, results are conflicting. These discrepancies are likely due in part to modest sample sizes and reliance on self-report measures to assess menstrual cycle phase. The present study aimed to clarify the impact of progestogens and estrogens on visuospatial cognition by relating mental rotation task performance to salivary hormone concentrations. Across two studies totaling 528 naturally-cycling premenopausal women, an internal meta-analysis suggested a small, positive effect of within-subjects changes in progesterone on MRT performance (estimate = 0.44, p = 0.014), though this result should be interpreted with caution given multiple statistical analyses. Between-subjects differences and within-subject changes in estradiol did not significantly predict MRT. These results shed light on the potential cognitive effects of endogenous and exogenous hormone action, and the proximate mechanisms modulating spatial cognition.The process of aging is linked with significant changes in a human’s physiological organization and structure. This is more evident in the case of the brain whose functions generally vary between young and old individuals. Detecting such patterns can be of significant importance especially during the Mild Cognitive Impairment (MCI) stage which is a transition state before the clinical onset of dementia. Intervening in that stage may delay or eventually prevent dementia onset. In this paper we propose a new methodology based in electroencephalographic (EEG) recordings, aiming to classify individuals into healthy, pathological (patients diagnosed with MCI or Mild Dementia) and young, old groups (healthy individuals over and under 50 years of age) through functional connectivity and macro-architecture features. These features are calculated on the estimated brain region activations through the inverse problem solution, enabling us to transform the sensor level EEG recordings through an appropriate transformation matrix. read more Afterwards, Synchronization Likelihood and Relative Wavelet Entropy values were calculated along with the graph metrics corresponding to the functional connectivity values, as well as the relative energy contributions of five EEG bands (delta, theta, alpha, beta and gamma). These features were organized in Red, Green, Blue (RGB) image-like data structures. Therefore, it was possible to classify each individual into one of the two groups per experiment employing Convolutional Neural Networks. From the maximum classification accuracy achieved on the test set, 90.48% for the pathological aging group and 91.19% for the physiological aging, it is evident that the proposed approach is capable of providing adequate health and age group classification.Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy. Neurons are particularly dependent on mitochondrial function, but how well mitochondria adapt to the new fate is unknown. Here, we determined the comprehensive mitochondrial proteome of cortical astrocytes and neurons, identifying about 150 significantly enriched mitochondrial proteins for each cell type, including transporters, metabolic enzymes, and cell-type-specific antioxidants. Monitoring their transition during reprogramming revealed late and only partial adaptation to the neuronal identity. Early dCas9-mediated activation of genes encoding mitochondrial proteins significantly improved conversion efficiency, particularly for neuron-enriched but not astrocyte-enriched antioxidant proteins. For example, Sod1 not only improves the survival of the converted neurons but also elicits a faster conversion pace, indicating that mitochondrial proteins act as enablers and drivers in this process. Transcriptional engineering of mitochondrial proteins with other functions improved reprogramming as well, demonstrating a broader role of mitochondrial proteins during fate conversion.Membrane proteins with multiple transmembrane domains play essential roles in the cell, but little is known about the machinery involved in the assembly of these domains into functional proteins. Two recent studies report the discovery of novel membrane protein chaperone complexes for the biogenesis of multi-pass membrane proteins.A symbiotic partnership with Blochmannia bacteria is thought to underpin the ecological success of carpenter ants. Disentangling the molecular interactions between the mutualistic partners supports an old hypothesis that many other ants also had similar symbioses and lost them.A new study uses an elegant in vivo assay to comprehensively characterize the LP docking motif, which determines G1-CDK substrate specificity in fungi. The authors show that LP-cyclin docking strength determines the timing of Sic1 degradation, a key cell cycle event.Ovules are initiated in a highly regular pattern along the placenta inside the gynoecia of flowering plants. New research reveals that two separate EPFL peptide-mediated pathways functioning through a set of ERECTA-family receptors coordinate ovule patterning with fruit growth.Animals use a variety of strategies to navigate their world, but few are thought to have detailed mental maps of their landscapes. New research with our closest relatives suggests chimpanzees may use cognitive maps to find the most energy efficient routes.Arabidopsis stomatal development requires asymmetric cell division, where the nucleus moves to the division site based on cellular polarity cues. A new study reveals the role of distinct cytoskeletal networks, both guided by the polarity factor BASL, for nuclear movement before and after division.Some primates, in particular lemurs, have long been known to communicate by smell. However, no bona fide primate pheromones have been identified. A recent study of ring-tailed lemurs offers some – disputed – candidate molecules for a male pheromone.