present study reveals that the prepared β-glucan accelerates intestinal epithelial cell proliferation and migration via activation of Rho-dependent pathway. Hence, β-glucan can be employed as a prospective therapeutic agent for the treatment of diseases associated with gastrointestinal mucosal damage, such as peptic ulcers and inflammatory bowel disease.

Chromolaena odorata (L) King and Robinson and Tridax procumbens Linn are used in traditional medicine in the treatment of diabetes mellitus and hypertension.

This study investigated the potential protective role of aqueous leaf-extracts of Chromolaena odorata and Tridax procumbens against cardiotoxicity induced by doxorubicin.

To this end, their impact on plasma markers of cardiac integrity, cardiac markers of oxidative stress, cardiac lipids and electrolyte profiles, and activities of cardiac ATPases, lactate dehydrogenase and creatine kinase, were monitored in doxorubicin treated rats. Metformin (250mg/kg body weight, orally) and both extracts (50, 75 and 100mg/kg, orally) were daily administered for 14 days; while cardiotoxicity was induced with doxorubicin (15mg/kg, intra-peritioneally, once on the 12th day of study).

The plasma activities of creatine kinase, lactate dehydrogenase and AST of Test control were significantly (p<0.05) higher than those of the other groups. Also, the cardiac malond oxidative stress and prevention of adverse alterations in plasma cardiac markers, cardiac lipids and electrolyte profiles, as well as improvement of the activities of cardiac ATPases, creatine kinase and lactate dehydrogenase.

Data are sparse regarding the clinical characteristics and management of fruit-induced anaphylaxis.

To assess clinical characteristics and management of patients with fruit-induced anaphylaxis and determine factors associated with severe reactions and epinephrine use.

Over 9 years, children and adults presenting with anaphylaxis to seven emergency departments in four Canadian provinces and patients requiring emergency medical services in Outaouais, Quebec were recruited as part of the Cross-Canada Anaphylaxis Registry. A standardized form documenting symptoms, triggers, and management was collected. Multivariate logistic regression was used to identify factors associated with severe reactions and epinephrine treatment in the pre-hospital setting.

We recruited 250 patients with fruit-induced anaphylaxis, median age 10.2 years (interquartile range, 3.6-23.4 years); 48.8% were male. The most common fruit triggers were kiwi (15.6%), banana (10.8%), and mango (9.2%). Twenty-three patients reported having eczema (9.3%). Epinephrine use was low in both the pre-hospital setting and the emergency department (28.4% and 40.8%, respectively). Severe reactions to fruit were more likely to occur in spring and among those with eczema (adjusted odds ratio [aOR]= 1.12, 95% confidence interval [CI], 1.03-1.23; and 1.17, 95% CI, 1.03-1.34, respectively). Patients with moderate and severe reactions (aOR= 1.23; 95% CI, 1.06-1.43) and those with a known food allergy (aOR= 1.38; 95% CI, 1.24-1.54) were more likely to be treated with epinephrine in the pre-hospital setting.

Severe anaphylaxis to fruit is more frequent in spring. Cross-reactivity to pollens is a potential explanation that should be evaluated further.

Severe anaphylaxis to fruit is more frequent in spring. Cross-reactivity to pollens is a potential explanation that should be evaluated further.How do people come to know others’ feelings? One idea is that affective processes (e.g., physiological responses) play an important role, leading to the prediction that linkage between one’s physiological responses and others’ emotions relates to one’s ability to know how others feel (i.e., empathic accuracy). Participants (N = 96, 48 female friend pairs) completed a stressful speech task and then provided continuous ratings of their own (as “targets”) and their friend’s (as “perceivers”) emotional experience for the video-taped speeches. selleck We measured physiology-physiology linkage (linkage between perceivers’ and targets’ physiology), physiology-experience linkage (linkage between perceivers’ physiology and targets’ experience), and empathic accuracy (linkage between perceivers’ ratings of targets’ experience and targets’ ratings of their experience). Physiology-experience (but not physiology-physiology) linkage was associated with greater empathic accuracy even when controlling for key potential confounds (random linkage, targets’ and perceivers’ emotional reactivity, and relationship closeness). Results suggest that physiological responses play a role in empathic accuracy.Increasing evidence indicates that the interaction between testosterone and cortisol is associated with variation in aggressive behavior. However, results are mixed. The current study further explored the association between testosterone, cortisol, and both reactive and proactive aggression in a large sample of university students. Models considered direct and interactive effects between baseline measures of testosterone and cortisol as well as change in hormones in response to a social stressor. In women, baseline cortisol had a negative direct association with reactive aggression and was further associated with reactive aggression in interaction with baseline testosterone (positive interaction). Hormones were unrelated to reactive aggression in men. Baseline cortisol had a negative direct association with proactive aggression in women. In contrast, the association between change in cortisol and proactive aggression was positive. Cortisol was not associated with proactive aggression in men. In addition, testosterone was not related to proactive aggression either directly or in interaction with cortisol in either men or women. Collectively, these results show that the association between hormones and aggression varies across aggressive behavior type and across sex.

To report 3 cases of reversible epitheliopathy induced by A166-a human epidermal growth factor receptor (HER2)-targeted antibody-drug conjugate (ADC) therapy for resistant HER2 tumours.

Advanced HER2 tumour patients were enrolled in A166 phase I/II clinical trial using Bayesian logistic regression model dose escalation. Key exclusion criteria were ≥grade 2 (G2) corneal pathology, severe organ disease, and other cancer therapy within 4 weeks. Eye exams were performed at baseline, regularly scheduled intervals, and additionally upon A166-induced ocular symptoms. Topical therapy with autologous serum tears (ASTs) was implemented based on visual acuity, symptoms, and slit lamp exam. A166 was withheld if ≥G2 ocular toxicity developed; if status improved to ≤G1, A166 therapy was resumed. Visual acuity, corneal exam, and subjective comfort were recorded.

After ≥2 cycles of A166, 6 eyes of 3/23 enrolled patients developed whorl pattern epitheliopathy suggestive of limbal stem cell (LSC) dysfunction requiring cessation of A166 despite positive tumour response.