The purpose of this study was to investigate the tissue reaction stimulated by BaSO4 – and Bi2 O3 -containing White MTA Angelus, in comparison with Bi2 O3 -containing white Portland cement, and white ProRoot MTA. Thirty-six adult male Wistar rats (Rattus norvegicus), weighing between 250 and 300 g, were distributed into three groups (n = 12) in accordance with the period of sacrifice (15, 30, and 60 days). Four polyethylene tubes filled with the tested cements were implanted into the dorsum of each rat. Lateral wall of the tubes served as the negative control. OICR-9429 chemical structure After the experimental periods, the animals were euthanized by overdose of pentobarbital anesthetic solution, and the specimens were prepared for microscopic analysis under ×50, ×100, and ×400 magnifications. Inflammatory scores (0-3) were used to grade the tissue reaction. Data were analyzed by the Kruskal-Wallis test and Dunn’s test for individual comparisons (p  .05). The Portland group had moderate inflammatory reaction at the final period of analysis, which was statistically different when compared to the other groups (p  less then  .05). The microscopic findings of this animal study suggest that the addition of BaSO4 to White MTA Angelus does not hampers the biocompatibility of the cement.

Development of new personal repellents to prevent tick bites is progressing to keep up with the increasing threat of tick-borne diseases in humans. However, the market share of natural, plant-based repellents is still quite small. We tested all of the major (>1%) components found in the essential oils of rosemary (Spanish variety) and nutmeg. These were tested with Dermacentor variabilis ticks, a robust tick capable of vectoring human diseases, in a no-human horizontal Petri dish assay. For comparison, we also tested the active ingredients currently recommended by the CDC and EPA as personal repellents for use against ticks.

Of the 16 oil components tested, three performed significantly better than N,N-diethyl-meta-toluamide (DEET) in our assay. These compounds were myristicin and safrole found in the nutmeg oil, and terpinolene found in nutmeg oil and as a minor (<1%) constituent of rosemary oil. The current market natural product, 2-undecanone, also performed strongly in our assay.

Our assay focused on comparing active ingredients as potential repellents and found that many natural products can elicit a strong response from ticks. Terpinolene is the most promising active ingredient identified, owing to human health concerns regarding myristicin and safrole. Our results from examining individual terpenoids from two essential oils suggest that there remain unexploited natural compounds that could be further developed for new personal tick repellents. © 2020 Society of Chemical Industry.

Our assay focused on comparing active ingredients as potential repellents and found that many natural products can elicit a strong response from ticks. Terpinolene is the most promising active ingredient identified, owing to human health concerns regarding myristicin and safrole. Our results from examining individual terpenoids from two essential oils suggest that there remain unexploited natural compounds that could be further developed for new personal tick repellents. © 2020 Society of Chemical Industry.

To compare thermocoagulation and cryotherapy for treatment of high-grade cervical intraepithelial neoplasia (CIN).

From May 2017 to May 2018, women with CIN2/3 were randomized to thermocoagulation or cryotherapy at Peking University Shenzhen Hospital. Follow-up at 4 and 8 months included cytology and human papillomavirus (HPV) testing. Women who were HPV-positive or had atypical squamous cells of undetermined significance or higher-grade disease underwent colposcopy/biopsy.

Among 149 women enrolled, 74 were randomized to thermocoagulation, and 75 to cryotherapy (excluded four were immediately referred for thermocoagulation due to large lesions). At follow-up, there was no difference between the thermocoagulation and cryotherapy groups in HPV-negative (4/8 months 72.5%/86.2% vs 68.6%/80.6%) and pathology-negative (97.1%/98.5% vs 94.3%/92.3%) rates (all P > 0.05). The cytology-negative rate was similar for thermocoagulation and cryotherapy at 4 months (79.7% vs 78.9%, P > 0.05), but higher for thermocoagulation at 8 months (100% vs 88.7%, P < 0.05). No lesions were observed among the four referral women at follow-up. As compared with cryotherapy, thermocoagulation was associated with shorter duration of treatment and less vaginal discharge, but higher pain during application and longer bleeding after treatment.

Thermocoagulation was as effective and safe as cryotherapy and might be easily applied to treat high-grade cervical lesions.

Thermocoagulation was as effective and safe as cryotherapy and might be easily applied to treat high-grade cervical lesions.

Alopecia areata (AA) and vitiligo are associated with various psychiatric comorbidities, and the care of a child with AA or vitiligo may be associated with higher anxiety and depression than healthy children.

We aimed to identify psychiatric findings in children and adolescent groups with AA and vitiligo and to evaluate the levels of anxiety and depression in their parents.

This study included 31 patients with AA and 29 patients with vitiligo, aged seven to 17years, and their parents. Age- and gender-matched 30 controls and their parents were included. The patients and controls completed the Revised Child Anxiety and Depression Scales-Child version (RCADS-C), and their parents completed the parent version (RCADS-P). The parents also completed the Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI). In addition, the stressful event history of all cases was noted.

Stressful event history was higher in the vitiligo group compared to the AA group, and it was higher in the AA and vitiligo groups compared to the control group. Separation anxiety, generalized anxiety, social phobia, and major depressive disorder (MDD) scores were higher in the AA group than controls according to the RCADS-C. According to the RCADS-P, panic disorder (PD), MDD, and total anxiety scores were higher in the AA group. Only the PD and MDD scores were higher in the vitiligo group than those of the controls based on the RCADS-P. Lastly, no significant difference was observed between the three groups concerning the parents’ BAI and BDI scores.

Stressful events were more common in pediatric patients with vitiligo than those with AA. Anxiety symptoms were more prevalent in patients with AA than those with vitiligo.

Stressful events were more common in pediatric patients with vitiligo than those with AA. Anxiety symptoms were more prevalent in patients with AA than those with vitiligo.