e.

To investigate the relationship between serum IgG (sIgG) concentration and the prognosis of IgA nephropathy (IgAN).

A total of 309 patients with biopsy-proven IgAN in the Second Referral Hospital of Shenzhen were enrolled between 2010/01 and 2017/06. Patients were divided into 3 groups on the basis of sIgG tertiles < 8.99 g/L (Group G1), 8.99 to 11.17 g/L (Group G2), and > 11.17 g/L (Group G3).

As the level of sIgG increased, there was a decrease in DBP, serum creatinine, 24h urine proteinuria and an increase in serum albumin (all P < .05). In terms of pathological manifestations, with increasing sIgG levels, there was a tendency of decline in the Lee’s grading system or high-grade tubular atrophy/interstitial fibrosis or in the proportion of glomerular sclerosis and the ratio of crescent (all P < .05). Kaplan-Meier analysis indicated that the cumulative renal survivals rates were significantly higher in patients with elevated sIgG (P < .05). Cox regression analysis showed that after adjusting for gender, age, BMI, and clinical indicators (BP, 24h urine proteinuria, eGFR, M, E, S, T, and the ratio of crescent), decreased sIgG level at the time of renal biopsy is an independent risk factor for unfavorable outcomes in IgAN. Furthmore, every 1 g/L decrease in sIgG level was associated with a 1.74-fold (95% CI 1.30 to 5.38) increased risk of the incidence of composite renal outcomes.

Decreased serum IgG level at baseline might be a kind of predictive marker for the poor prognosis of IgAN.

Decreased serum IgG level at baseline might be a kind of predictive marker for the poor prognosis of IgAN.

There is a mutual relationship between hypertension and renal failure, so that hypertension can be considered as a common finding in patients with end-stage renal disorders. Patients with persistent hypertension despite multiple medications are at high risk for adverse cardiovascular and kidney events. Some studies suggest that there is a correlation between RI and renal function in kidney diseases. Therefore, we conducted a study to investigate the relationship between renal arterial resistive index (RRI) and renal outcomes in patients with resistant hypertension.

This 2-years cross-sectional study was performed on patients with resistant hypertension. All patients undergo GFR, serum Cr and urine Alb tests. Then Doppler ultrasound was performed by a radiologist to measure RRI and was evaluated for the relationship between RRI and renal function.

Among 133 patients with resistant hypertension, 57.5% were male and the rest were female. Average age of participants and average RI were 48.26 ± 16.90 and 0.6l involvement in resistant hypertension.

The main causes of death in kidney transplant recipients are cardiovascular diseases and malignancy. This study aimed to determine the types of post-transplant malignancy, incidence, and related factors in renal transplant recipients referred to Razi Hospital in Rasht, Iran.

This retrospective cross-sectional study was conducted on 549 kidney transplant recipients between 1998 and 2018. Patient-, transplant-, and medication-related factors and pathology reports were recorded in the check list. Chi-square, T-test and Logistic Regression were used to investigate the effect of variables. Malignancy-person-year incidence rate was calculated using survival tables and Kaplan-Mayer analysis.

43 (7.8%) recipients had malignancies. The most common site of malignancy was the skin (53.5%). Non-Melanoma Skin Cancer (NMSC) was the most common cancer (32.6%) followed by Kaposi sarcoma (20.9%). The standardized incidence ratio (SIR) of post-transplant malignancies in renal transplant recipients was 26.9 times the malignancies in Guilan province and 21.7 times the malignancies in Iran. Cox proportional hazard models identified older age at the time of transplantation and history of azathioprine consumption seems to be associated with risk for post-transplant malignancy.

The most common malignancies in these people were non-melanoma skin cancer, Kaposi sarcoma and then GI malignancies. According to the information obtained in this study, regular periodic examinations of kidney transplant recipients for early detection of malignancy is important.

The most common malignancies in these people were non-melanoma skin cancer, Kaposi sarcoma and then GI malignancies. According to the information obtained in this study, regular periodic examinations of kidney transplant recipients for early detection of malignancy is important.Coronavirus disease 2019 (COVID-19) has been recently emerged with various manifestations, mainly on respiratory system. However, other organs might also be involved. Acute kidney injury has been reported as a complication with high variability and controversial results. We aimed to define the frequency of AKI as well as two specific renal biomarkers including BUN and serum Cr among individuals suffering from COVID-19 infection. We investigated Medline/PubMed, Scopus, and Google Scholar databases until 16th April 2020 and included all relevant peer-reviewed published studies without any language limitations. We further categorized patients according to their clinical status into severe, non-severe, and death groups. 18 records on 4528 individuals were assessed. The mean age of individuals were 52.5 ± 24.4 years (males 55.6%). Prevalence of AKI was 4% (95% CI 2% to 8%) and was significantly lower among non-severe patients in comparison to deceased ones (1%, 95% CI 0% to 4%, vs. 31%, 95% CI 19% to 47%). BUN mean was 5.14 mmol/L (95% CI 4.60 to 5.69). Non-severe patients had remarkably lower means of BUN compared to deceased or those with severe infection (4.25 mmol/L, 95% Cl 3.70 to 4.79, vs. 8.9 mmol/L, 95% CI 7.94 to 9.86, vs. 6.63 mmol/L, 95% Cl 5.62 to 7.65; respectively). The mean serum Cr was 71.60 mmol/L (95% Cl 67.56 to 75.64). Our findings suggest that COVID-19 does not seem to involve renal system extensively and other possible mechanisms might be further investigated in this regard.

Incidence of ductal carcinoma in situ (DCIS) has increased in recent decades because of breast cancer screening. This study comprised a long-term survival analysis of DCIS using 10-year territory-wide data from the Hong Kong Cancer Registry.

This study included all patients diagnosed with DCIS in Hong Kong from 1997 to 2006. Exclusion criteria were age <30 years or ≥70 years, lobular carcinoma in situ, Paget’s disease, and co-existing invasive carcinoma. Patients were stratified into those diagnosed from 1997 to 2001 and those diagnosed from 2002 to 2006. The 5- and 10-year breast cancer-specific survival rates were evaluated; standardised mortality ratios were calculated.

Among the 1391 patients in this study, 449 were diagnosed from 1997 to 2001, and 942 were diagnosed from 2002 to 2006. The mean age at diagnosis was 49.2±9.2 years. Overall, 51.2% of patients underwent mastectomy and 29.5% received adjuvant radiotherapy. ATM inhibitor The median follow-up interval was 11.6 years; overall breast cancer-specific mortality rates were 0.