01). GSZD decreased RANKL, and the number of osteoclasts (OCs) in joint tissues (

 < 0.01) and increased osteoprotegerin levels (

 < 0.01). GSZD inhibited RANKL-induced RAW264.7 differentiation and reduced bone resorption by OCs. GSZD upregulated IκB (

 < 0.01) and p65 (

 < 0.01) in the cytoplasm and downregulated p65 (

 < 0.01) in the cell nucleus.

decoction has an anti-RA effect, suggesting its possible use as a supplement and alternative drug therapy for RA.

Guizhi-Shaoyao-Zhimu decoction has an anti-RA effect, suggesting its possible use as a supplement and alternative drug therapy for RA.The time and effort students devote to learning tasks has been related to student success and outcomes, however, the way students understand and experience time during their health professional education remains poorly understood. This article aims to address this gap in knowledge through a qualitative analysis of health professional students’ engagement with a longitudinal portfolio assessment spanning two years. Thematic analysis of 7 focus groups conducted with oral health therapy students was performed. Four temporal dimensions of student engagement associated with the longitudinal portfolio assessment were identified the organising effect of the assessment structure and timeline; flows of learning over time; individual perceptions of time; and having a future orientation. A fifth theme identified that circumstances or events can make or break the temporal rhythms of any of the dimensions. Our findings show that students’ experiences of learning are affected by institutional arrangements as well as personal perceptions of time. Taking the experience of time beyond the concept of ‘time management’, we show how curricula contain under-recognised tools for students to authentically experience the complexities and contradictions of time in preparation for the context of health practice.The tetravalent dengue vaccine (CYD-TDV) is approved for use as a 3-dose series for the prevention of dengue in seropositive individuals ≥9 years. A randomized, placebo-controlled, phase II study of a booster dose of CYD-TDV in individuals who completed the 3-dose schedule >5 years previously (NCT02824198), demonstrated that a booster restored neutralizing antibody titers to post-dose 3 levels. We present additional immunogenicity assessments up to 24 months post-booster, and B- and T-cell responses in a participant subset. Participants aged 9-45 years that had received all three doses of CYD-TDV were randomized 31 to receive a booster dose of CYD-TDV (n = 89) or placebo (n = 29). Neutralizing antibody levels at Months 1, 6, 12, and 24 post-booster were assessed by plaque reduction neutralization test. In a subset, B-cell responses were assessed by a fluorescent immunospot assay, and T-cells analyzed by flow cytometry at Days 0, 7, 12, Months 1 and 12. We observed an increase of antibody titers Month 1 post-booster, then a gradual decline to Month 24. In the CYD-TDV booster group, an increase in plasmablasts was seen at Day 7 declining by Day 14, an increase in memory B-cells was observed at Day 28 with no persistence at Month 12. CYD-TDV booster recalled a CD8+ T-cell response, dominated by IFN-γ secretion, which decreased 12 months post-booster. This study showed a short-term increase in antibody titers and then gradual decrease following CYD-TDV booster injection >5 years after primary immunization, and the presence of memory B-cells activated following the booster, but with low persistence.How do people go about reading a room or taking the temperature of a crowd? When people catch a brief glimpse of an array of faces, they can focus their attention on only some of the faces. We propose that perceivers preferentially attend to faces exhibiting strong emotions and that this generates a crowd-emotion-amplification effect-estimating a crowd’s average emotional response as more extreme than it actually is. Study 1 (N = 50) documented the crowd-emotion-amplification effect. Study 2 (N = 50) replicated the effect even when we increased exposure time. Study 3 (N = 50) used eye tracking to show that attentional bias to emotional faces drives amplification. These findings have important implications for many domains in which individuals must make snap judgments regarding a crowd’s emotionality, from public speaking to controlling crowds.

Studies that evaluate the effectiveness of concussion laws often use only a single variable (ie, presence of the law), failing to account for law complexity. check details We examined the association between multiple design elements of state concussion laws and rates of sports-related concussion reporting among US high school athletes.

We derived 3 design elements of concussion laws from the 2009-2017 LawAtlas database (1) strength of law, (2) number of law revisions, and (3) speed of law adoption. We examined the association between these design elements and rates of new and recurrent sports-related concussion reporting from the 2009-2010 through 2016-2017 academic years in a nationally representative sample of high school athletes participating in High School Report Information Online, an online data collection tool.

A total of 7064 sports-related concussions (6332 [89.6%] new and 732 [10.4%] recurrent concussions) were reported during the study period, with an overall rate of 39.7 sports-related concussions per 100 000 athletic exposures (eg, game or practice). Rates of new concussion reporting were higher among high schools in states with medium- or high-strength concussion laws than in states with low-strength concussion laws and in states with at least 1 concussion law revision than in states with no concussion law revisions. Rates of recurrent concussion reporting were lower among high schools in states with ≥2 concussion law revisions than in states with <2 concussion law revisions. Early law adoption was associated with higher rates of new and recurrent concussion reporting, and late law adoption was associated with lower rates of new and recurrent concussion reporting.

Our findings may help inform legislators of the public health effect of concussion laws.

Our findings may help inform legislators of the public health effect of concussion laws.